Erika E Johnston

US Patent:

20050249953, Nov 10, 2005

Filed:

Apr 17, 2003

Appl. No.:

10/511425

Inventors:

Diego Gianolio - Boston MA, US
Erika Johnston - Waltham MA, US
Robert Miller - E. Bridgewater MA, US

International Classification:

B32B009/04
B32B031/00

US Classification:

428411100, 427569000

Abstract:

There are disclosed novel uses of aziridine compounds. The aziridine compounds can be formed into films by plasma deposition on a wide variety of substrates. The films prevent biofouling, impart biocompatible or antithrombotic properties, and can immobilize therapeutic and pharmaceutical agents to provide a drug delivery system.

US Patent:

20050281866, Dec 22, 2005

Filed:

May 23, 2005

Appl. No.:

11/136328

Inventors:

Peter Jarrett - Sudbury MA, US
Kenneth Messier - Griswold CT, US
Robert Miller - E. Bridgewater MA, US
C. Philbrook - Boston MA, US
Hildegard Kramer - Westport CT, US
J. Kablik - Tyngsboro MA, US
Erika Johnston - Waltham MA, US
Luis Avila - Arlington MA, US
Arthur Coury - Boston MA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61L015/16

US Classification:

424448000

Abstract:

Described herein are adhesive polymeric compositions and methods for using the compositions. The composition are adherent to the applied surface. The compositions, in certain embodiments, are biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications. The adherent polymeric compositions comprise a polymerized macromer network and an additive mixed or entangled in the polymerized macromer. The additive is bonded to a surface by at least one covalent bond or by secondary interactions and is not covalently bonded to the polymerized macromer network. Alternatively, the additive is bonded to the surface by at least one covalent bond and is also bonded to the macromer network. The disclosed compositions can be used as an improved barrier, coating or drug delivery system that due to the additive is highly adherent to an applied surface. The compositions of the present invention are typically non-toxic, water miscible and have adaptable characteristics depending on the macromers and additives used. For example, specific macromers can be used for targeted bioresorption rate and/or degradation rate of the applied composition.

US Patent:

20060204537, Sep 14, 2006

Filed:

Jun 20, 2003

Appl. No.:

10/518562

Inventors:

Buddy Ratner - Seattle WA, US
Connie Kwok - Seattle WA, US
Katie Walline - Boulder CO, US
Erika Johnston - Cambridge MA, US
Robert Miller - Cambridge MA, US

International Classification:

A61K 48/00
A61K 31/4745
A61F 2/02

US Classification:

424423000, 514044000, 514291000

Abstract:

The present invention provides a composition for use in delivering a drug into the body of a mammal, wherein the composition comprises silicone elastomer, an adjuvant polymer, and the drug. This composition may be part of an implantable medical device, such as a stent or a vascular or other graft or sheath, among other configurations. When the compositions are used as coating, the coating may further include a topcoat of silicone or silicone and adjuvant polymer mixture.

US Patent:

20080138842, Jun 12, 2008

Filed:

Nov 9, 2007

Appl. No.:

11/983671

Inventors:

Hans Boehringer - San Diego CA, US
Mark Daquipa - San Diego CA, US
Hsin Ming Yang - San Diego CA, US
Thomas L. Pisani - Winchester MA, US
Sumitra Nag - Lexington MA, US
Jay Salhaney - Holliston MA, US
Marcella B. Holdrige - Watertown MA, US
Erika Johnston - Lexington MA, US
Jeremy Schonhorn - Hopkinton MA, US

International Classification:

C12M 1/34
G01N 33/00

US Classification:

435 794, 4352872

Abstract:

Disclosed herein are indirect lateral flow sandwich assays, in which the target analyte binds an analyte-specific reagent comprising a first member of a conjugate pair, forming a complex which contacts and binds a colored particulate label comprising a complementary member of said conjugate pair, forming a second complex. Capture of this analyte-comprising, second complex by an immobilized analyte specific capture reagent results in the formation of an immobilized labeled sandwich complex that can be detected.

US Patent:

20120107956, May 3, 2012

Filed:

Sep 12, 2011

Appl. No.:

13/230550

Inventors:

HANS BOEHRINGER - San Diego CA, US
Mark Daquipa - San Diego CA, US
Hsin Ming Yang - San Diego CA, US
Thomas L. Pisani - Winchester MA, US
Sumitra Nag - Lexington MA, US
Jay Salhaney - Holliston MA, US
Marcella B. Holdridge - Watertown MA, US
Erika Johnston - Lexington MA, US
Jeremy Schonhorn - Hopkinton MA, US

International Classification:

G01N 21/78

US Classification:

436501

Abstract:

Disclosed herein are indirect lateral flow sandwich assays, in which the target analyte binds an analyte-specific reagent comprising a first member of a conjugate pair, forming a complex which contacts and binds a colored particulate label comprising a complementary member of said conjugate pair, forming a second complex. Capture of this analyte-comprising, second complex by an immobilized analyte specific capture reagent results in the formation of an immobilized labeled sandwich complex that can be detected.

US Patent:

20220267794, Aug 25, 2022

Filed:

Mar 27, 2020

Appl. No.:

17/598176

Inventors:

- Cambridge MA, US
Michael Beauregard - Boston MA, US
Guillaume Carmona - Cambridge MA, US
Francisco Caballero Gonzalez - Brookline MA, US
Richard Heidebrecht - Somerville MA, US
Erika Ellen Johnston - Cambridge MA, US
Robert James Miller - East Bridgewater MA, US
Owen O'Connor - Raynham MA, US
Matthias Alexander Oberli - Cambridge MA, US
David Peritt - Skokie IL, US
Jared A. Sewell - Somerville MA, US
Devyn McKinley Smith - Barrington RI, US
Omid Veiseh - Bellaire TX, US
Jeffrey Charles Way - Cambridge MA, US
Paul Kevin Wotton - Boston MA, US
Zoe Yin - Boston MA, US
Elina Makino - Winchester MA, US
Brian Richard Fluharty - Boston MA, US
Marianthi Papakosta - Cambridge MA, US

International Classification:

C12N 15/85
A61K 38/47
A61K 47/22
A61K 9/50
C08L 5/04

Abstract:

Described herein are RPE cells engineered to secrete a GLA protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating Fabry disease.

US Patent:

20230008121, Jan 12, 2023

Filed:

Dec 4, 2020

Appl. No.:

17/782368

Inventors:

- Cambridge MA, US
John Patrick Golden - Providence RI, US
Joseph Gordon - Providence RI, US
Erika Ellen Johnston - Cambridge MA, US
Robert James Miller - East Bridgewater MA, US
Justin David Morse - Providence RI, US
Peter Calvin Costello - Providence RI, US

International Classification:

G01N 1/31
B01D 43/00
B01J 2/04
B01J 13/08

Abstract:

Described herein are apparatuses and methods for conditioning particles. In some embodiments, the apparatuses and methods are configured for first-in-first-out transit of particles through a chamber containing a conditioning fluid.

US Patent:

20210145759, May 20, 2021

Filed:

Mar 27, 2019

Appl. No.:

17/045127

Inventors:

- Cambridge MA, US
Michael Beauregard - Boston MA, US
Guillaume Carmona - Cambridge MA, US
Francisco Caballero Gonzalez - Brookline MA, US
Richard Heidebrecht - Somerville MA, US
Erika Ellen Johnston - Cambridge MA, US
Robert James Miller - East Bridgewater MA, US
Matthias Alexander Oberli - Cambridge MA, US
Owen O'Connor - Raynham MA, US
David Peritt - Skokie IL, US
Jared A. Sewell - Somerville MA, US
Devyn McKinley Smith - Barrington RI, US
Omid Veiseh - Bellaire TX, US
Paul Kevin Wotton - Boston MA, US

International Classification:

A61K 9/50
A61K 35/28
A61K 35/30
C07K 14/755
C07K 14/62
C12N 9/64

Abstract:

Described herein are particles comprising a first compartment, a second compartment, and a compound of Formula (I), as well as compositions and methods of making and using the same. The particles may comprise a cell capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.