Ernest Richard Campbell

US Patent:

50934783, Mar 3, 1992

Filed:

Jul 14, 1989

Appl. No.:

7/379771

Inventors:

Owen W. Griffith - New York NY
Ernest B. Campbell - Corona NY

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

A61K 3702

US Classification:

530331

Abstract:

In the esterification of glutathione with alcohol in the presence of acid catalyst, neutral glutathione monoester is isolated in high yields without the intermedite isolation of ester acid salt by treating the reaction mixture with base anion exchange resin (basic form) to neutralize the acid and bind the resulting acid anion and unesterified glutatione. Dehydrating agent is used to drive the reaction toward esterification. In the production of glutathione monester acid salts a soluble dehydrating agent is advantageously used.