Ethan John Anderson

US Patent:

20090253641, Oct 8, 2009

Filed:

Feb 6, 2009

Appl. No.:

12/367267

Inventors:

P. Darrell Neufer - Greenville NC, US
Ethan J. Anderson - Greenville NC, US
Hazel H. Szeto - New York NY, US

International Classification:

A61K 38/07
A61P 3/08

US Classification:

514 18

Abstract:

The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (p) and the total number of amino acid residues (r) wherein 3is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (p) wherein 2is the largest number that is less than or equal to p+1, except that when a is 1, pmay also be 1.

US Patent:

20120149638, Jun 14, 2012

Filed:

Dec 2, 2011

Appl. No.:

13/310269

Inventors:

P. Darrell Neufer - Greenville NC, US
Ethan J. Anderson - Greenville NC, US
Hazel H. Szeto - New York NY, US

International Classification:

A61K 38/17
A61P 5/50

US Classification:

514 67

Abstract:

The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (p) and the total number of amino acid residues (r) wherein 3pis the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (p) wherein 2a is the largest number that is less than or equal to p+1, except that when a is 1, pmay also be 1.

US Patent:

20130303447, Nov 14, 2013

Filed:

Jul 19, 2013

Appl. No.:

13/946921

Inventors:

P. Darrell Neufer - Greenville NC, US
Ethan J. Anderson - Greenville NC, US
Hazel H. Szeto - New York NY, US

International Classification:

C07K 5/11

US Classification:

514 68

Abstract:

The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (p) and the total number of amino acid residues (r) wherein 3pis the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (p) wherein 2a is the largest number that is less than or equal to p+1, except that when a is 1, pmay also be 1.

US Patent:

20170100450, Apr 13, 2017

Filed:

May 19, 2016

Appl. No.:

15/159412

Inventors:

P. Darrell Neufer - Greenville NC, US
Ethan J. Anderson - Greenville NC, US
Hazel H. Szeto - New York NY, US

Assignee:

Cornell University - Ithaca NY
East Carolina University - Greenville NC

International Classification:

A61K 38/07

Abstract:

The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (p) and the total number of amino acid residues (r) wherein 3pis the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (p) wherein 2a is the largest number that is less than or equal to p+1, except that when a is 1, pmay also be 1.

US Patent:

20150359839, Dec 17, 2015

Filed:

Jan 15, 2015

Appl. No.:

14/598095

Inventors:

P. Darrell Neufer - Greenville NC, US
Ethan J. Anderson - Greenville NC, US
Hazel H. Szeto - New York NY, US

Assignee:

EAST CAROLINA UNIVERSITY - Greenville NC
CORNELL UNIVERSITY - Ithaca NY

International Classification:

A61K 38/07

Abstract:

The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (p) and the total number of amino acid residues (r) wherein 3pis the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (p) wherein 2a is the largest number that is less than or equal to p+1, except that when a is 1, pmay also be 1.