Eugene Harold Herman

US Patent:

20030049640, Mar 13, 2003

Filed:

Dec 27, 2001

Appl. No.:

10/033741

Inventors:

Eugene Herman - Takoma Park MD, US
Gordon Holt - Gaithersburg MD, US
Frank Sistare - Ellicott City MD, US
Jun Zhang - Rockville MD, US

International Classification:

C12Q001/68
G01N033/53
G01N033/542
G01N033/557

US Classification:

435/006000, 435/007900, 436/517000

Abstract:

The present invention provides methods and compositions for screening, diagnosis and prognosis of vascular response, for monitoring the effectiveness of vascular response treatment, identifying patients most likely to respond to a particular therapeutic treatment and for drug development. In particular, the screening of drug candidates for their ability to induce a vascular response. Vascular Response-Associated Features (VRFs), detectable by two-dimensional electrophoresis of blood, serum or plasma are described. The invention further provides Vascular Response-Associated Protein Isoforms (VRPIs) detectable in blood, serum or plasma, preparations comprising isolated VRPIs, antibodies immunospecific for VRPIs, and kits comprising the aforesaid.

US Patent:

20030092197, May 15, 2003

Filed:

Dec 27, 2001

Appl. No.:

10/033662

Inventors:

Eugene Herman - Takoma Park MD, US
Gordon Holt - Gaithersburg MD, US
Frank Sistare - Ellicott City MD, US
Jun Zhang - Rockville MD, US

International Classification:

G01N033/557
A61K031/00

US Classification:

436/517000, 514/001000

Abstract:

The present invention provides methods and compositions for screening, diagnosis and prognosis of Cardiac Response, for monitoring the effectiveness of Cardiac Response treatment and for drug development. Cardiac Response-Associated Features (CRFs) detectable by two-dimensional electrophoresis of blood are described. The invention further provides Cardiac Response-Associated Protein Isoforms (CRPIs) detectable in biological sample preparations comprising isolated CRPIs, antibodies specific for CRPIs and kits comprising the aforesaid.