Kirk J. Leister - Fayetteville NY, US Eugene J. Schaefer - Westfield NJ, US Ronald Charles Bates - Irvine CA, US Elizabeth A. Bramhall - Groton MA, US David Michael Didio - Syracuse NY, US Robert Donaldson - Southborough MA, US Alan R. Flesher - Lawrenceville NJ, US Helen Gray Haggerty - Manlius NY, US David Henry Kirkley - East Syracuse NY, US John Malcolm Tabor - Syracuse NY, US Lee K. Tay - Princeton Junction NJ, US Pallaiah Thammana - Manlius NY, US Ajoy Velayudhan - Cary NC, US David Edward Smolin - Pennington NJ, US Reb J. Russell - Doylestown PA, US Thomas James Vanden Boom - Flemington NJ, US Dean Woodrow Brownell - Oswego NY, US Jeffrey Schrimsher - Hillsborough NC, US Joyce Patricia Whitehead - Manlius NY, US
The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
Charles L. Cooney - Brookline MA Eugene J. Schaefer - Somerville MA
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12N 1500 C12N 926
US Classification:
435172
Abstract:
Maltase is produced by growing a mutant of the yeast strain Saccharomyces italicus capable of growing in a growth medium utilizing sucrose as the carbon source. Mutants of Saccharomyces italicus capable of utilizing sucrose as a carbon source also are provided.
Charles L. Cooney - Brookline MA Eugene J. Schaefer - Somerville MA
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12N 926 C12N 116
US Classification:
435201
Abstract:
Maltase is produced by growing a mutant of the yeast strain Saccharomyces italicus capable of growing in a growth medium utilizing sucrose as the carbon source. Maltase production is optimized by controlling time of fermentation, growth medium composition and sonication time during maltase recovery.
Compositions And Methods For Producing A Composition
- Princeton NJ, US Eugene J. Schaefer - Westfield NJ, US Ronald Charles Bates - Irvine CA, US Elizabeth A. Bramhall - Groton MA, US David Michael Didio - Syracuse NY, US Robert Donaldson - Southborough MA, US Alan R. Flesher - Lawrenceville NJ, US Helen Gray Haggerty - Manlius NY, US David Henry Kirkley - East Syracuse NY, US John Malcolm Tabor - Syracuse NY, US Lee K. Tay - Princeton Junction NJ, US Pallaiah Thammana - Manlius NY, US Ajoy Velayudhan - Cary NC, US David Edward Smolin - Pennington NJ, US Reb J. Russell - Doylestown PA, US Thomas James Vanden Boom - Flemington NJ, US Dean Woodrow Brownell - Oswego NY, US Jeffrey Schrimsher - Hillsborough NC, US Joyce Patricia Whitehead - Manlius NY, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07K 14/705 A61K 38/19 C07K 16/28
Abstract:
The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
- Princeton NJ, US Eugene J. Schaefer - Westfield NJ, US Ronald Charles Bates - Irvine CA, US Elizabeth A. Bramhall - Groton MA, US David Michael Didio - Syracuse NY, US Robert Donaldson - Southborough MA, US Alan R. Flesher - Lawrenceville NJ, US Helen Gray Haggerty - Manlius NY, US David Henry Kirkley - East Syracuse NY, US John Malcolm Tabor - Syracuse NY, US Lee K. Tay - Princeton Junction NJ, US Pallaiah Thammana - Manlius NY, US Ajoy Velayudhan - Cary NC, US David Edward Smolin - Pennington NJ, US Reb J. Russell - Doylestown PA, US Thomas James Vanden Boom - Flemington NJ, US Dean Woodrow Brownell - Oswego NY, US Jeffrey Schrimsher - Hillsborough NC, US Joyce Patricia Whitehead - Manlius NY, US
The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
Compositions And Methods For Producing A Composition
- Princeton NJ, US Eugene J. Schaefer - Westfield NJ, US Ronald Charles Bates - Irvine CA, US Elizabeth A. Bramhall - Groton MA, US David Michael Didio - Syracuse NY, US Robert Donaldson - Southborough MA, US Alan R. Flesher - Lawrenceville NJ, US Helen Gray Haggerty - Manlius NY, US David Henry Kirkley - East Syracuse NY, US John Malcolm Tabor - Syracuse NY, US Lee K. Tay - Princeton Junction NJ, US Pallaiah Thammana - Manlius NY, US Ajoy Velayudhan - Cary NC, US David Edward Smolin - Pennington NJ, US Reb J. Russell - Doylestown PA, US Thomas James Vanden Boom - Flemington NJ, US Dean Woodrow Brownell - Oswego NY, US Jeffrey Schrimsher - Hillsborough NC, US Joyce Patricia Whitehead - Manlius NY, US
The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
- Princeton NJ, US Eugene J. Schaefer - Westfield NJ, US Ronald Charles Bates - Irvine CA, US Elizabeth A. Bramhall - Groton MA, US David Michael Didio - Syracuse NY, US Robert Donaldson - Southborough MA, US Alan R. Flesher - Lawrenceville NJ, US Helen Gray Haggerty - Manlius NY, US David Henry Kirkley - East Syracuse NY, US John Malcolm Tabor - Syracuse NY, US Lee K. Tay - Princeton Junction NJ, US Pallaiah Thammana - Manlius NY, US Ajoy Velayudhan - Cary NC, US David Edward Smolin - Pennington NJ, US Reb J. Russell - Doylestown PA, US Thomas James Vanden Boom - Flemington NJ, US Dean Woodrow Brownell - Oswego NY, US Jeffrey Schrimsher - Hillsborough NC, US Joyce Patricia Whitehead - Manlius NY, US
The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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