Eun Y Lee

US Patent:

7074561, Jul 11, 2006

Filed:

Oct 22, 2002

Appl. No.:

10/277645

Inventors:

Roxanne N. Shurtliff - Herndon VA, US
Eun Mi Lee - Rockville MD, US

Assignee:

bioMerieux, Inc. - Durham NC

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/04

US Classification:

435 6, 435 912, 435810, 536 221, 536 243

Abstract:

The present invention is directed to isothermal transcription based assays for the detection and quantification of alpha-fetoprotein (AFP) mRNA. The present invention is also directed to oligonucleotides for amplifying AFP mRNA and probes for use in the detection and quantification of the amplification product. The present invention is also directed to detecting hepatocellular carcinoma, metastasis thereof and tumor recurrence by analyzing peripheral blood for the presence of AFP mRNA.

US Patent:

7164019, Jan 16, 2007

Filed:

Jun 8, 2005

Appl. No.:

11/147851

Inventors:

Eun Kyung Lee - San Jose CA, US
Chris Richard Melville - Palo Alto CA, US
David Mark Rotstein - Sunnyvale CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

C07D 239/24

US Classification:

544335

Abstract:

Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3. 3. 0]octane compounds according to formula (I) are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are allieviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula I.

US Patent:

RE39588, Apr 24, 2007

Filed:

Oct 31, 1990

Appl. No.:

07/606462

Inventors:

Eun Soo Lee - Redwood City CA, US
Su Il Yum - Los Altos CA, US

Assignee:

Alza Corporation - Mountain View CA

International Classification:

A61F 3/00

US Classification:

424449, 424448, 424484

Abstract:

A diffusional drug delivery device is described which can provide for stability of the adhesive and system components, elimination of the initial burst of drug and hence irritation, and to provide for delayed onset of therapeutic effect along with delivery of a therapeutic agent at an optimum rate. The therapeutic agent in a first form which is suitable for storage, and the anhydrous activating means are inert when in an anhydrous environment. Moisture activates the system whereby the activating means provides an acidic or basic solution and the first form of the therapeutic agent is converted to a second form which is suitable for absorption through the skin or mucosa.

US Patent:

7244738, Jul 17, 2007

Filed:

Jul 2, 2004

Appl. No.:

10/884768

Inventors:

Terrence Joseph Connolly - Redwood City CA, US
Paul Francis Keitz - Redwood City CA, US
Eun Kyung Lee - San Jose CA, US
Jim Li - San Jose CA, US
Francisco Javier Lopez-Tapia - Union City CA, US
Patrick Finbar McGarry - Mountain View CA, US
Chris Richard Melville - Palo Alto CA, US
Dov Nitzan - San Jose CA, US
Counde O'Yang - Sunnyvale CA, US
Fernando Padilla - Fremont CA, US
Klaus Kurt Weinhardt - San Francisco CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

A61K 31/517
A01N 43/54
C07D 239/72
A61K 31/549
C07D 417/02
C07D 285/26

US Classification:

5142663, 5142662, 544287

Abstract:

Compounds represented by Formula I:.

US Patent:

7714018, May 11, 2010

Filed:

Dec 11, 2006

Appl. No.:

11/637423

Inventors:

Eun Kyung Lee - San Jose CA, US
Chris Richard Melville - Palo Alto CA, US
David Mark Rotstein - Sunnyvale CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

A61K 31/40
C07D 487/02
C07D 491/02
C07D 495/02
C07D 497/02
C07D 209/44
C07D 209/52

US Classification:

514412, 548453, 548515

Abstract:

Chemokine receptor antagonists, in particular, 3,7-diazabicyclo[3. 3. 0]octane compounds according to formula (I) are antagonists of chemokine CCR5 receptors which are useful for treating or preventing an human immunodeficiency virus (HIV) infection, or treating AIDS or ARC. The invention further provides methods for treating diseases that are alleviated with CCR5 antagonists. The invention includes pharmaceutical compositions and methods of using the compounds for the treatment of these diseases. The invention further includes processes for the preparation of compounds according to formula I.

US Patent:

8158803, Apr 17, 2012

Filed:

Apr 23, 2010

Appl. No.:

12/766064

Inventors:

Eun Kyung Lee - Cupertino CA, US
Ryan Craig Schoenfeld - San José CA, US
Francisco Xavier Talamas - Mountain View CA, US

Assignee:

Roche Palo Alto LLC - South San Francisco CA

International Classification:

C07D 211/72
A61K 31/44

US Classification:

546290, 514345

Abstract:

Compounds having the formula I wherein R, R, R, R, R, R, Rand Rare as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.

US Patent:

8198274, Jun 12, 2012

Filed:

Jul 15, 2009

Appl. No.:

12/460199

Inventors:

Eun Kyung Lee - San Jose CA, US
Ryan Craig Schoenfeld - San Jose CA, US
Robert James Weikert - Boulder Creek CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

A61K 31/5377
A61K 31/404
A61K 31/4725
A61K 31/496
A61P 25/22
C07D 209/18
C07D 209/14
C07D 401/10
C07D 403/10
C07D 413/10

US Classification:

5142352, 51425409, 514307, 514415, 544143, 544373, 546148, 548469

Abstract:

This application discloses compounds of generic Formula I:.

US Patent:

20040018494, Jan 29, 2004

Filed:

Jul 25, 2002

Appl. No.:

10/202639

Inventors:

Roxanne Shurtliff - Herndon VA, US
Eun Lee - Rockville MD, US
Joseph Romano - Wayne PA, US

International Classification:

C12Q001/68
C07H021/02

US Classification:

435/006000, 536/023100

Abstract:

The present invention is directed to an isothermal transcription based assay for the detection and quantification of guanylyl cyclase C (GCC). The present invention is also directed to oligonucleotides for amplifying GCC RNA and probes for use in the detection and quantification of the amplification product. Finally, the present invention is directed to a method for detecting colon carcinoma, micrometastasis thereof and tumor recurrence by analyzing peripheral blood for the presence of GCC.