Eun Jung Lee

US Patent:

7229973, Jun 12, 2007

Filed:

May 19, 2003

Appl. No.:

10/640739

Inventors:

You Han Bae - Salt Lake City UT, US
Kun Na - Salt Lake City UT, US
Eun Seung Lee - Salt Lake City UT, US

International Classification:

A61K 31/704

US Classification:

514 34, 424 7822, 424 7823, 424450, 424484, 424486, 523122

Abstract:

Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of making poly(L-histidine), synthetic intermediates, and block copolymers are also described.

US Patent:

7371781, May 13, 2008

Filed:

Sep 22, 2004

Appl. No.:

10/948078

Inventors:

You Han Bae - Salt Lake City UT, US
Kun Na - Salt Lake City UT, US
Eun Seong Lee - Salt Lake City UT, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

A61K 47/00

US Classification:

5147721, 424400, 514772

Abstract:

Drug delivery compositions for specific delivery of a drug to a tumor are described. These compositions include a core for sequestering the drug and a shell to which a ligand is attached for delivery of a drug to target cells. Since normal cells may also be targeted by the ligand, the compositions embed the ligand in the shell until the localized conditions surrounding the tumor cause the ligand to be displayed on the surface of the shell. One composition exhibits shrinkage of the shell at tumor pH, whereas another composition exhibits extension of the ligand at tumor pH. Still another composition causes the ligand to be exhibited at an elevated temperature.

US Patent:

7659314, Feb 9, 2010

Filed:

May 14, 2004

Appl. No.:

10/846487

Inventors:

You Han Bae - Salt Lake City UT, US
Kun Na - Salt Lake City UT, US
Eun Seong Lee - Salt Lake City UT, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

A61K 47/00
A61K 9/00
A01K 25/00

US Classification:

5147721, 424400, 514772

Abstract:

Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.

US Patent:

7951846, May 31, 2011

Filed:

May 4, 2009

Appl. No.:

12/435283

Inventors:

You Han Bae - Salt Lake City UT, US
Kun Na - Salt Lake City UT, US
Eun Seong Lee - Salt Lake City UT, US

International Classification:

A61K 47/00
A61K 9/00
A01K 25/00

US Classification:

5147721, 424400, 514772

Abstract:

Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.

US Patent:

8263664, Sep 11, 2012

Filed:

Jun 18, 2009

Appl. No.:

12/487574

Inventors:

Dongin Kim - Salt Lake City UT, US
Zhonggao Gao - Salt Lake City UT, US
Eun Seong Lee - Salt Lake City UT, US
You Han Bae - Salt Lake City UT, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

A61K 47/00
A61K 9/00
A01N 25/00

US Classification:

5147721, 424400, 514772

Abstract:

Mixed micelles containing poly(L-histidine-co-phenylalanine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.

US Patent:

8394391, Mar 12, 2013

Filed:

Aug 31, 2007

Appl. No.:

11/897979

Inventors:

You Han Bae - Salt Lake City UT, US
Eun Seong Lee - Salt Lake City UT, US
Dongin Kim - Salt Lake City UT, US
Yu Seok Youn - Salt Lake City UT, US
Kyung Taek Oh - Salt Lake City UT, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT

International Classification:

A61K 9/00

US Classification:

424400

Abstract:

A drug delivery vehicle for targeted delivery of a drug mimics viral properties of size, capsid-like protein capsule, cell-specific entry, toxin release, destruction of infected cells, and migration to neighboring cells. This vehicle, termed a virogel, contains a hydrophobic polymeric core, a hydrophilic inner shell, a hydrophilic outer shell, and a ligand. An illustrative drug-loaded virogel includes poly(L-histidine-co-phenylalanine) as the core, doxorubicin loaded in the core, polyethylene glycol as the inner shell, bovine serum albumin as the outer shell, and folic acid as the ligand.

US Patent:

20030199472, Oct 23, 2003

Filed:

Mar 19, 2003

Appl. No.:

10/392274

Inventors:

Eun Lee - Northbrook IL, US
J. Jameson - Winnetka IL, US

International Classification:

C12Q001/68
A61K048/00

US Classification:

514/044000, 435/006000

Abstract:

The present invention provides methods of treating and preventing uterine fibroids that is non-surgical, using a modified estrogen receptor gene delivered via an adenoviral vector. The modified estrogen receptor induced apoptosis in vitro and decreased tumor growth in vivo. The invention provides a major improvement above that of current available procedures for women having uterine fibroids, or in preventing fibroids in women at risk of having fibroids. The present invention further provides a safe means of treating fibroids and preserving fertility in young women, or maintaining pregnancy in pregnant women having fibroids.