Eunjee Lee

US Patent:

20100153018, Jun 17, 2010

Filed:

Sep 29, 2009

Appl. No.:

12/569794

Inventors:

Harmen J. Bussemaker - New York NY, US
Eunjee Lee - New York NY, US

International Classification:

G06F 19/00

US Classification:

702 19

Abstract:

The disclosed subject matter is directed to genetic linkage methods for identifying genetic determinants of transcription factor activity. An inferred transcription factor activity profile is generated based on a nucleotide sequence-specific mathematical model of gene expression regulation. Genetic linkage analysis is performed to identify at least one genetic determinant linked to a specific transcription factor segregant based on the inferred transcription factor profile.