Evelina R Loghin

US Patent:

8647829, Feb 11, 2014

Filed:

Jul 7, 2009

Appl. No.:

12/498485

Inventors:

Aaron Dulgar-Tulloch - Clifton Park NY, US
Ernest William Kovacs - Albany NY, US
Evelina Roxana Loghin - Rexford NY, US
Anup Sood - Clifton Park NY, US

Assignee:

General Electric Company - Niskayuna NY

International Classification:

G01N 33/53
G01N 31/00

US Classification:

435 721, 435 71, 436 86, 436501, 436518, 514 23, 514 80, 514424, 514532, 530300, 530350

Abstract:

Methods and kits for binding and releasing biological targets, comprising, a binder comprising an environmentally reactive molecular switch that can switch between a high affinity state, to bind the target, to a low affinity state, to release the target.

US Patent:

20100104513, Apr 29, 2010

Filed:

Oct 28, 2008

Appl. No.:

12/259944

Inventors:

Jens Rittscher - Ballston Lake NY, US
Umesha Perdoor Srinivas Adiga - Clifton Park NY, US
Kenneth Michael Fish - Clifton Park NY, US
Anup Sood - Clifton Park NY, US
Kathleen Bove - Ballston Lake NY, US
Evelina Roxana Loghin - Rexford NY, US

Assignee:

General Electric Company - Schenectady NY

International Classification:

A61K 49/00
G06K 9/00

US Classification:

424 91, 382128

Abstract:

The present disclosure generally relates to systems and methods for identifying the boundaries of tumors and assessing quantitatively the ability of dyes to highlight a tumor's boundary. In accordance with these methods and systems, images are taken of subjects administered agents labeled with dyes. After accessing the images, tumors are selected and routines employed to both identify the boundaries of the tumors, as well as, to quantify various aspects of the tumor boundaries. From these quantifiable descriptors the performances of the various dyes to highlight the boundaries of tumors are evaluated.

US Patent:

20100143258, Jun 10, 2010

Filed:

Dec 5, 2008

Appl. No.:

12/328802

Inventors:

Anup Sood - Clifton Park NY, US
Jason William Castle - Esperance NY, US
Evelina Roxana Loghin - Rexford NY, US
Natalie Anne Staples - Albany NY, US
Kenneth Michael Fish - Clifton Park NY, US
Randall Lee Carter - Clifton Park NY, US
Brian Duh-Lan Lee - Rexford NY, US
Kathleen Bove - Ballston Lake NY, US

Assignee:

GENERAL ELECTRIC COMPANY - SCHENECTADY NY

International Classification:

A61K 49/00
C07K 2/00

US Classification:

424 96, 530345

Abstract:

In one aspect, the present invention provides a functionalized monodisperse polylysine comprising a linear monodisperse polylysine chain comprising constituent lysine monomer residues containing appended C-Cpolyethylene glycol groups and at least one appended fluorescent dye moiety is provided.

US Patent:

20110076764, Mar 31, 2011

Filed:

Sep 30, 2009

Appl. No.:

12/570032

Inventors:

Slawomir Rubinsztain - Ballston Spa NY, US
Prameela Susarla - Clifton Park NY, US
Reginald Donova Smith - Schenectady NY, US
Evelina Roxana Loghin - Rexford NY, US

Assignee:

GENERAL ELECTRIC COMPANY - SCHENECTADY NY

International Classification:

C12N 5/077
C12N 5/00

US Classification:

435366, 435378, 435402

Abstract:

Methods and kits of releasing cells are provided. The method comprises the steps of providing cultured cells on a cell culture support comprising a multi layer polyelectrolyte coating immobilized on a substrate, and releasing the cultured cells from the cell culture support by a releasing solution comprising DMSO. The kit comprises a cell culture support and a releasing solution. The releasing solution comprises DMSO.

US Patent:

20130052725, Feb 28, 2013

Filed:

Oct 31, 2011

Appl. No.:

13/285976

Inventors:

Siavash Yazdanfar - Niskayuna NY, US
Vasile Bogdan Neculaes - Niskayuna NY, US
Kenneth Roger Conway - Clifton Park NY, US
Allen Lawrence Garner - Clifton Park NY, US
Evelina Roxana Loghin - Rexford NY, US
Dmitry Vladimirovich Dylov - Schenectady NY, US
Brian Michael Davis - Albany NY, US
Chulmin Joo - Niskayuna NY, US

Assignee:

GENERAL ELECTRIC COMPANY - SCHENECTADY NY

International Classification:

C12M 1/42

US Classification:

4352891

Abstract:

A system for delivering exogenous molecules comprises a support for containing cells and exogenous molecules; an infra-red (IR) light source that generates an IR optical beam with an average power density at least greater than 10W/cm; one or more optical elements; an imaging system to image the cells in a field of view; a processor that generates a signal for localization of cells in the field of view; a light pattern shaper for temporal focusing of optical beam to generate wide field illumination on the cells to permeabilise the cell membrane for delivering the exogenous molecules; and a controller that switches optical beam from wide field illumination to a focused illumination. The processor is operatively coupled to the imaging system and the light pattern shaper and transmits the signal for the localization of cells to ensure the temporal focusing of the optical beam on the cells.

US Patent:

20130052738, Feb 28, 2013

Filed:

Aug 30, 2011

Appl. No.:

13/221161

Inventors:

Vasile Bogdan Neculaes - Niskayuna NY, US
Kenneth Roger Conway - Clifton Park NY, US
Allen Lawrence Garner - Clifton Park NY, US
Evelina Roxana Loghin - Rexford NY, US
Siavash Yazdanfar - Niskayuna NY, US
Dmitry Vladimirovich Dylov - Schenectady NY, US
Brian Michael Davis - Albany NY, US
Chulmin Joo - Niskayuna NY, US

Assignee:

GENERAL ELECTRIC COMPANY - SCHENECTADY NY

International Classification:

C12N 13/00
C12N 15/63
C12N 15/81
C12N 15/85
C12N 15/82
B82Y 5/00

US Classification:

435455, 4351735, 435468, 435471, 977773, 977902

Abstract:

A method of delivering exogenous molecules, comprising: providing a plurality of cells having a cell membrane; adding a plurality of exogenous molecules to the cells; exposing the cells to a defocused infrared (IR) light to permeabilize the cell membrane of the cells; and delivering the exogenous molecules to the cells through the permeablized cell membrane, wherein an intensity of the IR light at the optical focus is at least greater than or equal to an order of 10W/cm.

US Patent:

20130171729, Jul 4, 2013

Filed:

Feb 25, 2013

Appl. No.:

13/776053

Inventors:

GENERAL ELECTRIC COMPANY - Schenectady NY, US
Prameela Susarla - Ballston Spa NY, US
Reginald Donovan Smith - Schenectady NY, US
Evelina Roxana Loghin - Rexford NY, US

Assignee:

GENERAL ELECTRIC COMPANY - Schenectady NY

International Classification:

C12N 5/00

US Classification:

435378

Abstract:

Methods and kits of releasing cells are provided. The method comprises the steps of providing cultured cells on a cell culture support comprising a multi layer polyelectrolyte coating immobilized on a substrate, and releasing the cultured cells from the cell culture support by a releasing solution comprising DMSO. The kit comprises a cell culture support and a releasing solution. The releasing solution comprises DMSO.

US Patent:

20140057282, Feb 27, 2014

Filed:

Nov 5, 2013

Appl. No.:

14/071805

Inventors:

Ernest William Kovacs - Cohoes NY, US
Evelina Roxana Loghin - Rexford NY, US
Anup Sood - Clifton Park NY, US

Assignee:

General Electric Company - Schenectady NY

International Classification:

G01N 1/34
C07K 14/00

US Classification:

435 71, 530321

Abstract:

Methods and kits for binding and releasing biological targets, comprising, a binder having an environmentally reactive molecular switch that can switch between a high affinity state, to bind the target, to a low affinity state, to release the target. In one embodiment, the binder is a pre-existing chemical sequence, composition, or structural configuration but unknown or unspecified and still viable as a binder for attaching a molecular switch.