Faith M Harris

US Patent:

20130185819, Jul 18, 2013

Filed:

Mar 11, 2013

Appl. No.:

13/793812

Inventors:

Andrew J. MURPHY - Croton-on-Hudson NY, US
Cagan GURER - Valhalla NY, US
John MCWHIRTER - Tarrytown NY, US
Vera VORONINA - Thornwood NY, US
Faith HARRIS - Mamaroneck NY, US
Sean STEVENS - San Francisco CA, US
Yingzi XUE - Ardsley NY, US

Assignee:

REGENERON PHARMACEUTICALS, INC. - Tarrytown NY

International Classification:

A01K 67/027

US Classification:

800 18, 800 14, 536 234

Abstract:

The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

US Patent:

20130111617, May 2, 2013

Filed:

Oct 26, 2012

Appl. No.:

13/661159

Inventors:

Andrew J. MURPHY - Croton-on-Hudson NY, US
Cagan GURER - Valhalla NY, US
John MCWHIRTER - Tarrytown NY, US
Vera VORONINA - Thornwood NY, US
Faith HARRIS - Mamaroneck NY, US
Sean STEVENS - San Francisco CA, US

Assignee:

REGENERON PHARMACEUTICALS, INC. - Tarrytown NY

International Classification:

A01K 67/027
A01K 67/02
C12N 15/06

US Classification:

800 18, 800 14, 800 21, 800 22

Abstract:

The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

US Patent:

20210029978, Feb 4, 2021

Filed:

Sep 24, 2020

Appl. No.:

17/031367

Inventors:

- Tarrytown NY, US
Faith Harris - Mamaroneck NY, US
Vera Voronina - Sleepy Hollow NY, US
John McWhirter - Hastings-on-Hudson NY, US
Natasha Levenkova - New York NY, US
Lynn Macdonald - Harrison NY, US
Naxin Tu - Pleasantville NY, US
Andrew J. Murphy - Croton-on-Hudson NY, US

Assignee:

Regeneron Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

A01K 67/027
C07K 16/00
C12N 15/90

Abstract:

Non-human animals (and/or non-human cells) and methods of using and making the same are provided, which non-human animals (and/or non-human cells) have a genome comprising human antibody-encoding sequences (i.e., immunoglobulin genes). Non-human animals described herein express antibodies that contain human Igλ light chains, in whole or in part. In particular, non-human animals provided herein are, in some embodiments, characterized by expression of antibodies that contain human Igλ light chains, in whole or in part, that are encoded by human Igλ light chain-encoding sequences inserted into an endogenous Igλ light chain locus of said non-human animals. Methods for producing antibodies from non-human animals are also provided.

US Patent:

20200375159, Dec 3, 2020

Filed:

Aug 6, 2020

Appl. No.:

16/986844

Inventors:

- Tarrytown NY, US
Andrew J. Murphy - Croton-on-Hudson NY, US
Cagan Gurer - Chappaqua NY, US
John McWhirter - Hastings-on-Hudson NY, US
Vera Voronina - Sleepy Hollow NY, US
Faith Harris - Mamaroneck NY, US
Sean Stevens - Del Mar CA, US
Yingzi Xue - Ardsley NY, US

International Classification:

A01K 67/027

Abstract:

The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

US Patent:

20200375160, Dec 3, 2020

Filed:

Aug 12, 2020

Appl. No.:

16/991283

Inventors:

- Tarrytown NY, US
Andrew J. Murphy - Croton-on-Hudson NY, US
Cagan Gurer - Chappaqua NY, US
John McWhirter - Hastings-on-Hudson NY, US
Vera Voronina - Sleepy Hollow NY, US
Faith Harris - Mamaroneck NY, US
Sean Stevens - Del Mar CA, US

International Classification:

A01K 67/027
C07K 14/74

Abstract:

The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

US Patent:

20180288986, Oct 11, 2018

Filed:

Jun 21, 2018

Appl. No.:

16/015159

Inventors:

- Tarrytown NY, US
Andrew J. Murphy - Croton-on-Hudson NY, US
Cagan Gurer - Chappaqua NY, US
John McWhirter - Hastings-on-Hudson NY, US
Vera Voronina - Sleepy Hollow NY, US
Faith Harris - Mamaroneck NY, US
Sean Stevens - Del Mar CA, US
Yingzi Xue - Ardsley NY, US

International Classification:

A01K 67/027

Abstract:

The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized β2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.

US Patent:

20180125043, May 10, 2018

Filed:

Nov 3, 2017

Appl. No.:

15/803513

Inventors:

- Tarrytown NY, US
Faith Harris - Mamaroneck NY, US
Vera Voronina - Sleepy Hollow NY, US
John McWhirter - Tarrytown NY, US
Natasha Levenkova - New York NY, US
Lynn Macdonald - Harrison NY, US
Naxin Tu - Pleasantville NY, US
Andrew J. Murphy - Croton-On-Hudson NY, US

International Classification:

A01K 67/027
C07K 16/00

Abstract:

Non-human animals (and/or non-human cells) and methods of using and making the same are provided, which non-human animals (and/or non-human cells) have a genome comprising human antibody-encoding sequences (i.e., immunoglobulin genes). Non-human animals described herein express antibodies that contain human Igλ light chains, in whole or in part. In particular, non-human animals provided herein are, in some embodiments, characterized by expression of antibodies that contain human Igλ light chains, in whole or in part, that are encoded by human Igλ light chain-encoding sequences inserted into an endogenous Igλ light chain locus of said non-human animals. Methods for producing antibodies from non-human animals are also provided.

US Patent:

20170347633, Dec 7, 2017

Filed:

Jun 2, 2017

Appl. No.:

15/612625

Inventors:

- Tarrytown NY, US
Andrew J. Murphy - Croton-On-Hudson NY, US
Chunguang Guo - Thornwood NY, US
Natasha Levenkova - New York NY, US
Naxin Tu - Pleasantville NY, US
John McWhirter - Tarrytown NY, US
Vera Voronina - Sleepy Hollow NY, US
Faith Harris - Mamaroneck NY, US

International Classification:

A01K 67/027
C12N 5/0735
C07K 14/725
C07K 16/46
C12N 5/0783
C12N 9/12

Abstract:

Provided herein are methods and compositions related to non-human animals that express exogenous Terminal Deoxynucleotidyltransferase (TdT).