Fang Fang - San Diego CA, US Michael Malakhov - San Diego CA, US
Assignee:
NexBio, Inc. - San Diego CA
International Classification:
A61K 38/46 C12N 9/14
US Classification:
424 946, 435195
Abstract:
The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
Fang Fang - San Diego CA, US Lori Kohlstaedt - La Jolla CA, US John Reno - San Diego CA, US
Assignee:
Perlan Therapeutics, Inc. - San Diego CA
International Classification:
C07K 16/28 C12P 21/08
US Classification:
5303873, 53038822
Abstract:
Humanized antibodies that bind ICAM-1 are provided. Antibodies include those selected from: SEQ ID NO:1 and 3 (HumA); SEQ ID NO:5 and 7 (HumB); SEQ ID NO:9 and 11 (HumC); SEQ ID NO:13 and 15 (HumD); SEQ ID NO:17 and 19 (HumE); SEQ ID NO:21 and 23 (HumF); SEQ ID NO:25 and 27 (HumG); SEQ ID NO:29 and 31 (HumH); and SEQ ID NO:33 and 35 (HumI). Subsequences of the humanized antibodies capable of binding an ICAM-1 epitope are also provided. Methods of inhibiting pathogen infection (e. g. , HRV) of a cell employing humanized antibodies capable of binding an ICAM-1 epitope are further provided.
Fang Fang - San Diego CA, US Michael Malakhov - San Diego CA, US
Assignee:
NexBio, Inc. - San Diego CA The United States of America/NIH - Washington DC
International Classification:
A61K 39/00 C12N 9/36
US Classification:
4241921, 435206
Abstract:
The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
Broad Spectrum Anti-Viral Therapeutics And Prophylaxis
Mang Yu - San Diego CA, US Fang Fang - San Diego CA, US Michael Malakhov - San Francisco CA, US
Assignee:
NexBio, Inc. - San Diego CA
International Classification:
A61K 39/00 C12N 9/36
US Classification:
4241921, 435206
Abstract:
The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of the target cell by a pathogen, such as a virus. Preferred target cells are epithelial cells. The invention provides compositions and methods for preventing viral diseases, such as influenza, using compounds having anchoring domains that can bind target cells linked to enzymatic activities that can act extracellularly to interfere with viral infection of target cells. The invention also provides compositions and methods for preventing viral diseases such as influenza using compounds having anchoring domains that can bind target cells linked to protease inhibitors that can act extracellularly to interfere with viral infection of target cells.
Multimeric Proteins And Methods Of Making And Using Same
Fang Fang - San Diego CA, US Lori Allison Kohlstaedt - La Jolla CA, US Catherine Helen Charles - Encinitas CA, US
Assignee:
Perlan Therapeutics, Inc. - San Diego CA
International Classification:
A61K 38/17 C12P 21/04 C07K 14/435
US Classification:
514 212, 514 213, 530350, 435 697
Abstract:
The invention provides multimerization polypeptides capable of conferring formation of multimers when the multimerization polypeptide is linked to a molecule, such as a heterologous polypeptide sequence.
Methods, Compounds, And Compositions For Treatment And Prophylaxis In The Respiratory Tract
Fang Fang - Rancho Santa Fe CA, US David Wurtman - San Diego CA, US Ron Moss - Encinitas CA, US Michael P. Malakhov - San Francisco CA, US
Assignee:
NexBio, Inc. - San Diego CA
International Classification:
A61K 38/46
US Classification:
424 9465
Abstract:
The present invention provides a method of reducing the quanitity of mucus in the respiratory tract of a subject with elevated levels of mucus in said respiratory tract. The method includes administering to the subject a compound or composition containing a therapeutically effective amount of a fusion protein comprising a sialidase or an active portion thereof and an anchoring domain. The therapeutically effective amount comprises an amount of the fusion protein that results in a reduction of the quanitity of mucus in the respiratory tract after administration of the compound or composition when compared to the quantity of mucus present prior to administration of the compound or composition.
Fang Fang - San Diego CA, US Michael Malakhov - San Francisco CA, US
Assignee:
Ansun Biopharma, Inc. - San Diego CA
International Classification:
C12N 9/24
US Classification:
4241921, 435206
Abstract:
The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
Fang Fang - San Diego CA, US Lori Kohlstaedt - La Jolla CA, US John Reno - San Diego CA, US
Assignee:
Perlan Therapeutics, Inc. - San Diego CA
International Classification:
C07K 16/28 C12N 15/13 C12N 15/63 A61K 39/395
US Classification:
5303873, 536 2353, 4353201, 4241331
Abstract:
Humanized antibodies that bind ICAM-1 are provided. Antibodies include those selected from: SEQ ID NO:1 and 3 (HumA); SEQ ID NO:5 and 7 (HumB); SEQ ID NO:9 and 11 (HumC); SEQ ID NO:13 and 15 (HumD); SEQ ID NO:17 and 19 (HumE); SEQ ID NO:21 and 23 (HumF); SEQ ID NO:25 and 27 (HumG); SEQ ID NO:29 and 31 (HumH); and SEQ ID NO:33 and 35 (HumI). Subsequences of the humanized antibodies capable of binding an ICAM-1 epitope are also provided. Methods of inhibiting pathogen infection (e. g. , HRV) of a cell employing humanized antibodies capable of binding an ICAM-1 epitope are further provided.
Iowa Department of Public Health Des Moines, IA Jul 2013 to Jan 2014 Community Health ConsultantIowa State University Entomology Department Ames, IA Mar 2013 to May 2013 Technical AssistantBeijing Yi Xing Property Co. Ltd
May 2012 to Jul 2012 Administrative AssistantIowa State University Ames, IA Feb 2012 to May 2012 Academic Tutor (calculus)Des Moines Area Community College Des Moines, IA Jan 2010 to May 2011 Maths Tutor (calculus, algebra)
Education:
Iowa State University Ames, IA 2011 to 2013 B.S. in StatisticsDes Moines Area Community College Des Moines, IA 2009 to 2011 Environmental Science
Skills:
Microsoft Windows and Office (Word, Excel, and PowerPoint), SAS , R ,JMP, VB.
I think Fang Fang wrote about what happened, said Amy Ye, the organizer of a volunteer group for disabled people in Wuhan. In fact, I dont think she included the most serious situations. Her diary is very moderate. I dont understand why even something like that couldnt be tolerated.
Date: Jan 24, 2021
Category: More news
Source: Google
Report: Suspected Chinese spy targeted Bay Area politicians, then disappeared
But what Congressman Eric Swalwell and others didnt know was Christine Fang, or Fang Fang, was a suspected Chinese spy, according to a one-year investigation by Axios. U.S. intelligence officials told the news organization that Chinas main civilian spy agency ran an operation developing connection
Date: Dec 09, 2020
Category: Headlines
Source: Google
Nine Days in Wuhan, the Ground Zero of the Coronavirus Pandemic
On February 19th, Fang Fang noted that a significant number of early deaths happened before there was proper testing and diagnosis. So Im afraid that we still dont have a completely accurate tally of just how many victims there really are, she wrote.e of this is due to a cultural differencethe Chinese response to errors is often tolook forward, not back. On January 31st, Fang Fang commented in her diary, The Chinese people have never been fond of admitting their own mistakes, nor do they have a very strong sense of repentance. Its often haIm not passionate about politics, Fang Fang told me, explaining that she just liked to record things accurately. She is a small woman with lively eyes, andshe presented me with a copy of one of her banned books, Soft Burial. The novel covers the issue of land reform around the time that the CoAt sixty-five, Fang Fang is retired, though she receives a pension from the government-sponsored Hubei Writers Association. She said that two local officials from a different government bureau had visited and tried to persuade her to withdraw the overseas publication of Wuhan Diary, but she refusEvery Wuhan writer I met spoke highly, and protectively, of Fang Fang. In provincial China, literary communities tend to be tight-knit, and writers learn to be thick-skinned and resourceful. When Fang Fangs Weibo account was suspended, a number of tech-savvy young Chinese helped her find other ways
Date: Oct 05, 2020
Category: More news
Source: Google
'Wuhan Diary' Brings Account Of China's Coronavirus Outbreak To English Speakers
rapidly spread there, becomes available in English on Friday as Wuhan Diary: Dispatches from a Quarantined City. Bits and clips of Fang Fang's writing on the situation in Wuhan made it out of China and into English as the outbreak was unfolding, but now the full account will be available in English.Memory is central to Fang Fang's diary. So is making sense of the complete absence of things: of life as we knew it; of any and all economic activity. Like tens of millions of other readers, I read Fang Fang in the monotony of self-isolation, looking for a common understanding of how the pandemic haBy early February, China's Internet censors were working overtime, during the height of the epidemic, to erase critical content. Fang Fang's diary thus often serves as an archive, describing videos and news items usually deleted by the time she managed to publish her daily entry. As her online diary"You have that whole connecting universe extending from her diary entries...of course, reading it now, after the fact, is a very different experience," Berry, who is also translating Fang Fang's last novel, Soft Burial, told NPR. Still, readers in the U.S. will likely find many of her gripes about l"Imagine this: the author Fang Fang did not exist in today's Wuhan...What would we have heard? What would we have seen?" asked writer Yan Lianke in a widely-shared online talk in late February. Memory, Yan goes on to say, is the most basic hedge against future injustice: "While memories may not giveaising questions does not make one popular in China these days. Nearly immediately after she began publishing her entries, an online army of ultra-nationalists deluged Fang Fang, indignant that in airing doubts about the superiority of China's coronavirus containment she was betraying her motherland.One anonymous letter, allegedly written by a high school student, lambasted Fang Fang for airing China's dirty laundry out for everyone to see. "My child, I also want to tell you that when I was 16 years old, I was much worse off than you are. At that time, I had never even heard of words like 'indeVoices like Fang Fang's who remember well the brutal decade of the Cultural Revolution, when adolescent Maoists tortured, persecuted and beat to death the politically incorrect, as well as the subsequent prosperity of economic reform and opening are increasingly rare in China. But in the context
Date: May 14, 2020
Category: World
Source: Google
As Coronavirus Fades in China, Nationalism and Xenophobia Flare
Her writings are being used to blackmail China, to demand that China pay compensation, to bring China to trial, to interrogate China, Sima Nan, a Maoist scholar and well-known defender of Communist Party rule, said about Fang Fang in an interview. She has become a political tool.
Date: Apr 16, 2020
Category: More news
Source: Google
JPMorgan Hires UBS's David Li as China Head, Replacing Zili Shao
Li replaces Zili Shao, JPMorgans former China chairman andchief executive officer, who was named the banks Asia-Pacificvice chairman in April. Fang Fang, the companys CEO ofinvestment banking for China, resigned in March after more than12 years at the firm amid an investigation by U.S. regula
We are building business across the board, not only in investment banking, but also in corporate banking, institutional investors services, treasury services and commodities, Fang Fang, 46, said in an interview in Beijing yesterday. We are seeing some very interesting talents.
The continued yuan internationalization is expected to ease the concern of channeling proceeds from onshore to offshore, said Fang Fang, chief executive of China investment banking at J.P. Morgan Chase & Co .
Date: Sep 17, 2012
Category: Business
Source: Google
Youtube
My Cousin - Fang Fang (Part 1)
This is a recording showing my cousin Fang Fang, who is now working as...
Category:
People & Blogs
Uploaded:
21 May, 2007
Duration:
7m 35s
Thye Hua Kwan Charity Show 2012 Pt 4 of 4
For the complete Charity Show follow the link below:- www.youtube.com ...
Category:
Nonprofits & Activism
Uploaded:
25 Mar, 2012
Duration:
41m 42s
Vivimos en Andaluca - Captulo 1 - "Fang Fang"...
"Vivimos en Andaluca" es una serie de reportajes audiovisuales que rec...
Category:
People & Blogs
Uploaded:
16 Apr, 2012
Duration:
5m 9s
RED FANG - "Wires"
click the link below to vote for "Wires" as the best video of the year...
Category:
Music
Uploaded:
12 May, 2011
Duration:
5m 56s
Red Fang "Prehistoric Dog" (high quality feat...
The new music video for Red Fang's "Prehistoric Dog" Directed by White...
Category:
Music
Uploaded:
29 Oct, 2008
Duration:
5m 27s
RED FANG - "Hank Is Dead"
Buy at Relapse: bit.ly Buy at iTunes: bit.ly RED FANG - "Hank Is Dead"...
Category:
Music
Uploaded:
26 Jan, 2012
Duration:
3m 14s
Googleplus
Fang Fang
Fang Fang
Education:
National University of Singapore - Information Systems, Wuhan University - Information Management&Information Systems
Fang Fang
Education:
University at Buffalo, The State University of New York