Theresa A. Deisher - Seattle WA Darrell C. Conklin - Seattle WA Fenella Raymond - Seattle WA Thomas R. Bukowski - Seattle WA Susan D. Holderman - Kirkland WA Birgit Hansen - Seattle WA Paul O. Sheppard - Redmond WA
Assignee:
ZymoGenetics, Inc. - Seattle WA
International Classification:
A61K 3800
US Classification:
514 2, 435 71, 530350, 5303871, 4241921
Abstract:
The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
Nucleic Acid Which Encodes The Tumor Marker Zsig62
Studies indicate that mutations in tumor suppressor genes occur early in the process of carcinogenesis, and that these mutations are correlated with a subsequent development of cancer. The detection of such alterations would provide useful molecular markers for diagnosis, surveillance, early tumor identification and intervention, and prognosis. A novel human gene, designated as âZsig62,â resides within a region of chromosome 16 that is associated with prostate and breast cancer, and that appears to contain tumor suppressor genes. Like a tumor suppressor gene, the Zsig62 gene is expressed in particular normal tissues, but not in tumors derived from those tissues.
Theresa A. Deisher - Seattle WA Darrell C. Conklin - Seattle WA Fenella Raymond - Seattle WA Thomas R. Bukowski - Seattle WA Susan D. Holderman - Seattle WA Birgit Hansen - Seattle WA Paul O. Sheppard - Redmond WA
Assignee:
ZymoGenetics, Inc. - Seattle WA
International Classification:
C07K 1450
US Classification:
514 2, 514 12, 530350, 530399, 435 697
Abstract:
The present invention relates to polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.
Theresa A. Deisher - Seattle WA, US Darrell C. Conklin - Seattle WA, US Fenella Raymond - Seattle WA, US Thomas R. Bukowski - Seattle WA, US Susan D. Holderman - Kirkland WA, US Birgit Hansen - Seattle WA, US Paul O. Sheppard - Redmond WA, US
Assignee:
ZymoGenetics, Inc. - Seattle WA
International Classification:
A61K 38/18 A61K 39/00 C07K 14/50
US Classification:
514 2, 530350, 5303871, 530300, 4241921
Abstract:
The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
Theresa A. Deisher - Seattle WA, US Darrell C. Conklin - Seattle WA, US Fenella C. Raymond - Seattle WA, US Thomas R. Bukowski - Seattle WA, US Susan D. Holderman - Seattle WA, US Paul O. Sheppard - Redmond WA, US
The present invention relates to antibodies and fragments thereof, polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.
Novel mammalian calcitonin-like polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
Studies indicate that mutations in tumor suppressor genes occur early in the process of carcinogenesis, and that these mutations are correlated with a subsequent development of cancer. The detection of such alterations would provide useful molecular markers for diagnosis, surveillance, early tumor identification and intervention, and prognosis. A novel human gene, designated as “Zsig62,” resides within a region of chromosome 16q that is associated with prostate and breast cancer, and that appears to contain tumor suppressor genes. Like a tumor suppressor gene, the Zsig62 gene is expressed in particular normal tissues, but not in tumors derived from those tissues.
Theresa Deisher - Seattle WA, US Darrell Conklin - Seattle WA, US Fenella Raymond - Seattle WA, US Thomas Bukowski - Seattle WA, US Susan Holderman - Seattle WA, US Paul Sheppard - Redmond WA, US
The present invention relates to polynucleotide and polypeptide molecules for ZFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.
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