Feng C Chen

US Patent:

7936299, May 3, 2011

Filed:

Jun 30, 2009

Appl. No.:

12/495794

Inventors:

Oliver Richard Astley - Niskayuna NY, US
Naresh Kesavan Rao - Niskayuna NY, US
Feng Chen - Niskayuna NY, US

Assignee:

General Electric Company - Niskayuna NY

International Classification:

H03M 1/12

US Classification:

341172, 341155, 341156

Abstract:

A circuit for converting a charge signal into a binary format of output bits comprises: an integration circuit including an operational transconductance amplifier having an inverting input terminal and an output terminal, an integrating capacitor connected between the inverting input terminal and the output terminal, the integrating capacitor for storing a charge input selectively provided by a sensor diode; and a folding circuit having a fold capacitor, the fold capacitor switchably coupled either to a fold voltage source via a fold buffer for charging the fold capacitor to a predetermined fold charge value, or to the integrating capacitor for selectively removing at least a portion of the stored charge input.

US Patent:

20040157935, Aug 12, 2004

Filed:

Feb 2, 2004

Appl. No.:

10/769830

Inventors:

Gregg Henderson - St. Gabriel LA, US
Donald Heumann - Metairie LA, US
Roger Laine - Baton Rouge LA, US
Lara Maistrello - Fondo di Russi (RA) LA, US
Betty Zhu - Baton Rouge LA, US
Feng Chen - Clemson SC, US

International Classification:

A01N035/00

US Classification:

514/691000

Abstract:

Extracts of vetiver oil were found to be significant repellents and toxicants of ants, ticks, and cockroaches. Nootkatone was shown to significantly decrease ant invasion and increase mortality in fire ants. Nootkatone is an effective repellent and toxicant of ants either by itself or as an addition to other substrates, including mulches made from vetiver grass roots, diatomaceous earth, alumina, silica, clays; building materials made from either aluminum or wood; and other suitable solid substances. Nootkatone was also a repellent and toxicant to ticks; and a repellent to cockroaches. Nootkatone is non-toxic to humans and other mammals and is environmentally safe. In addition, it is believed that other extracts of vetiver oil, specifically -cedrene, zizanol and bicyclovetivenol, will be effective against ants, ticks, and cockroaches.

US Patent:

20060099721, May 11, 2006

Filed:

Oct 6, 2005

Appl. No.:

11/244567

Inventors:

Feng Chen - Central SC, US
Ashby Bodine - Clemson SC, US
Paul Dawson - Central SC, US
Thomas Scott - Central SC, US
Ya-Ping Sun - Clemson SC, US
Xi Wang - Central SC, US

International Classification:

G01N 33/551

US Classification:

436524000

Abstract:

A radioimmunoassay method for determining the quantity of an analyte of interest in a sample is disclosed. The analyte of interest may be an antigen or other chemical entity. A known antibody to the antigen or other entity is employed and is conjugated to a functionalized nanoparticle. Because of the high surface area presented by the present nanoparticle-antibody conjugates, the present radioimmunoassay method is particularly suited for the qualitative and quantitative analysis of low molecular weight chemicals.

US Patent:

20080241967, Oct 2, 2008

Filed:

Feb 6, 2008

Appl. No.:

12/069136

Inventors:

Feng Chen - Central SC, US
A. B. Bodine - Clemson SC, US
Paul L. Dawson - Clemson SC, US
Thomas R. Scott - Central SC, US
Xi Wang - Central SC, US

International Classification:

G01N 33/536

US Classification:

436542

Abstract:

A radioimmunoassay method for determining the quantity of an analyte of interest in a sample is disclosed. The analyte of interest may be an antigen or other chemical entity. A known antibody to the antigen or other entity is employed and is conjugated to a functionalized nanoparticle. Because of the high surface area presented by the present nanoparticle—antibody conjugates, the present radioimmunoassay method is particularly suited for the qualitative and quantitative analysis of low molecular weight chemicals.

US Patent:

20090030088, Jan 29, 2009

Filed:

Apr 21, 2008

Appl. No.:

12/148574

Inventors:

Xi Wang - Central SC, US
James C. Morris - Clemson SC, US
Feng Chen - Central SC, US
Thomas Beckham - Charleston SC, US

Assignee:

Clemson University - Clemson SC

International Classification:

A61K 31/11
A61P 31/00
A61P 35/00

US Classification:

514700

Abstract:

6-methoxy gossypol and 6,6′-dimethoxy gossypol were isolated from cottonseeds. Bioactivities of these two gossypol derivatives and gossypol were investigated regarding their antioxidant activities, DNA damage prevention ability, anti-cancer, and anti-trypanosomal activities. Both methoxy compounds had nearly equivalent bioactivities, but gossypol showed greater bioactivities than either methoxy derivative on free radical scavenging activity, reducing power, and DNA damage prevention ability. Gossypol and its methoxy derivatives inhibited growth of three cancer cell lines, i.e., SiHa (cervical cancer), MCF-7 (breast cancer) and Caco-2 (colon cancer) cells, in a dose dependent manner. These three compounds also significantly inhibited growth of trypanosome , the cause of African Sleeping Sickness, which affects thousands in western and central Africa.

US Patent:

20090175885, Jul 9, 2009

Filed:

Apr 5, 2007

Appl. No.:

12/225940

Inventors:

Xi Wang - Central SC, US
Feng Chen - Central SC, US

Assignee:

Clemson University - Clemson SC

International Classification:

A61K 39/395
G01N 33/566
A61P 35/00

US Classification:

4241751, 435 792

Abstract:

An assay system is provided in which gossypol is used as a biological marker to detect evolved resistance of insects to Bt cotton. Detection of gossypol using a monoclonal antibody ELISA-based protocol enables at risk populations of insects to be evaluated for evolved resistance to Bt present in a genetically modified cotton.The specificity of the monoclonal antibody to gossypol also enables the production of nanoparticles having a conjugated monoclonal antibody which retains the ability to selectively bind gossypol. Accordingly, nanoparticles can be provided with additional target ligands, such as antibodies, so as to specifically attach to tumors or cancer cells thereby delivering the gossypol to the target cells.

US Patent:

20130149723, Jun 13, 2013

Filed:

Jun 14, 2012

Appl. No.:

13/507238

Inventors:

Xi Wang - Central SC, US
Feng Chen - Central SC, US

Assignee:

Clemson University - Clemson SC

International Classification:

C07K 17/10
G01N 33/68

US Classification:

435 792, 5303917, 428402

Abstract:

An assay system is provided in which gossypol is used as a biological marker to detect evolved resistance of insects to Bt cotton. Detection of gossypol using a monoclonal antibody ELISA-based protocol enables at risk populations of insects to be evaluated for evolved resistance to Bt present in a genetically modified cotton.The specificity of the monoclonal antibody to gossypol also enables the production of nanoparticles having a conjugated monoclonal antibody which retains the ability to selectively bind gossypol. Accordingly, nanoparticles can be provided with additional target ligands, such as antibodies, so as to specifically attach to tumors or cancer cells thereby delivering the gossypol to the target cells.

US Patent:

20190216413, Jul 18, 2019

Filed:

Jan 16, 2018

Appl. No.:

15/872169

Inventors:

- Schenectady NY, US
Jiahua Fan - New Berlin WI, US
Mingye Wu - Glenville NY, US
Feng Chen - Niskayuna NY, US
Bruno Kristiaan Bernard De Man - Clifton Park NY, US

International Classification:

A61B 6/00
A61B 6/03

Abstract:

The present approach relates to avoiding azimuthal blur in a computed tomography context, such as in dual energy imaging with fast kV switching. In accordance with certain aspects, the focal spot position is held stationary in the patient coordinate system within each respective view and the detector signals within the view are summed. In one embodiment, this results in the low and high energy views within the signal being collected from the same position within the patient coordinate system.