Feng Li

US Patent:

20110294806, Dec 1, 2011

Filed:

Dec 11, 2009

Appl. No.:

12/998873

Inventors:

Jiwei Qi - West Roxbury MA, US
Yihan Wang - Newton MA, US
Feng Li - Winchester MA, US
William C. Shakespeare - Southborough MA, US
Anna Kohlmann - Winchster MA, US
David C. Dalgarno - Brookline MA, US
Xiaotian Zhu - Newton MA, US

Assignee:

ARIAD Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31/437
A61P 35/00
A61K 31/506
C07D 471/04
A61K 31/5377

US Classification:

5142345, 546113, 544127, 544333, 514300, 514256

Abstract:

This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.

US Patent:

20120202776, Aug 9, 2012

Filed:

May 21, 2009

Appl. No.:

12/736910

Inventors:

Yihan Wang - Newton MA, US
Wei-Sheng Huang - Acton MA, US
Shuangying Liu - Wellesley MA, US
William C. Shakespeare - Southborough MA, US
R. Mathew Thomas - Sharon MA, US
Jiwei Qi - West Roxbury MA, US
Feng Li - Winchester MA, US
Xiaotian Zhu - Newton MA, US
Anna Kohlmann - Winchester MA, US
David C. Dalgarno - Brookline MA, US
Jan Antoinette C. Romero - Somerville MA, US
Dong Zou - Concord MA, US

Assignee:

ARIAD Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31/675
C07F 9/6512
C07F 9/6561
A61P 35/00
C07F 9/6509
C07F 9/6521
C07F 9/58
C07F 9/6558
C07F 9/6584

US Classification:

514 81, 544243, 544122, 544244, 544232, 544195, 544113, 514 86, 514 80, 514 85, 546 22, 514 89, 514 84, 514 90

Abstract:

The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.

US Patent:

20120315338, Dec 13, 2012

Filed:

Dec 3, 2010

Appl. No.:

13/512827

Inventors:

Feng Li - Marlborough MA, US

Assignee:

Stem Cell & Regenerative Medicine International, Inc. - Marlborough MA

International Classification:

C12N 5/078
A61K 35/14
A61P 7/04
G01N 33/566

US Classification:

424532, 435377, 435372, 435325, 435373, 435354, 435 721

Abstract:

The present invention provides a method of generating megakaryocytes and platelets. In various embodiments, method involves the use of human embryonic stem cell derived hemangioblasts for differentiation into megakaryocytes and platelets under serum and stromal-free condition. In this system, hESCs are directed towards megakaryocytes through embryoid body formation and hemangioblast differentiation. Further provided is a method of treating a subject in need of platelet transfusion.

US Patent:

20130225527, Aug 29, 2013

Filed:

Mar 15, 2013

Appl. No.:

13/843171

Inventors:

ARIAD PHARMACEUTICALS, INC. - , US
Wei-Sheng Huang - Acton MA, US
Shuangying Liu - Wellesley MA, US
William C. Shakespeare - Southborough MA, US
R. Mathew Thomas - Sharon MA, US
Jiwei Qi - West Roxbury MA, US
Feng Li - Winchester MA, US
Xiaotian Zhu - Newton MA, US
Anna Kohlmann - Winchester MA, US
David C. Dalgarno - Brookline MA, US
Jan Antoinette C. Romero - Somerville MA, US
Dong Zou - Concord MA, US

Assignee:

ARIAD PHARMACEUTICALS, INC. - Cambridge MA

International Classification:

C07F 9/6584
C07F 9/6521
C07F 9/58
C07F 9/6558
C07F 9/6561

US Classification:

514 81, 544243, 514 86, 435184, 544122, 544244, 544232, 514 85, 546 22, 514 89, 544195, 514 84, 544182

Abstract:

The invention features compounds of the general formula:in which the variable groups are as defined herein, and to their preparation and use.

US Patent:

20130225528, Aug 29, 2013

Filed:

Mar 15, 2013

Appl. No.:

13/843055

Inventors:

ARIAD Pharmaceuticals, Inc. - , US
Wei-Sheng Huang - Acton MA, US
Shuangying Liu - Wellesley MA, US
William C. Shakespeare - Southborough MA, US
R. Mathew Thomas - Sharon MA, US
Jiwei Qi - West Roxbury MA, US
Feng Li - Winchester MA, US
Xiaotian Zhu - Newton MA, US
Anna Kohlmann - Winchester MA, US
David C. Dalgarno - Brookline MA, US
Jan Antoinette C. Romero - Somerville MA, US
Dong Zou - Concord MA, US

Assignee:

ARIAD PHARMACEUTICALS, INC. - Cambridge MA

International Classification:

C07F 9/6512
C07F 9/6584

US Classification:

514 83, 435375, 514 85, 514 86, 514 89, 544122, 544182, 544214, 544232, 544243, 544244, 546 22

Abstract:

The invention features compounds of the general formula:in which the variable groups are as defined herein, and to their preparation and use.

US Patent:

20140066406, Mar 6, 2014

Filed:

Mar 15, 2013

Appl. No.:

13/842951

Inventors:

ARIAD PHARMACEUTICALS, INC. - , US
Wei-Sheng Huang - Acton MA, US
Shuangying Liu - Wellesley MA, US
William C. Shakespeare - Southborough MA, US
R. Mathew Thomas - Sharon MA, US
Jiwei Qi - West Roxbury MA, US
Feng Li - Winchester MA, US
Xiaotian Zhu - Newton MA, US
Anna Kohlmann - Winchester MA, US
David C. Dalgarno - Brookline MA, US
Jan Antoinette C. Romero - Somerville MA, US
Dong Zou - Concord MA, US

Assignee:

ARIAD PHARMACEUTICALS, INC. - Cambridge MA

International Classification:

C07F 9/6558
C07F 9/6509
C07F 9/6584
C07F 9/6512
C07F 9/6561

US Classification:

514 84, 544243, 514 86, 544122, 544244, 514 81, 544232, 514 85, 544195, 544113, 544182

Abstract:

The invention features compounds of the general formula:in which the variable groups are as defined herein, and to their preparation and use.

US Patent:

20220380716, Dec 1, 2022

Filed:

Sep 11, 2020

Appl. No.:

17/642027

Inventors:

- CORNING NY, US
Kirsten Lee Cooper - Waltham MA, US
Feng Li - Shrewsbury MA, US
Sweta Nimesh Parikh - Salem NH, US
Rongjun Zuo - West Roxbury MA, US

International Classification:

C12M 1/00
C12M 1/32
C12M 1/12
B65D 81/18
B65D 81/38
B65D 81/02

Abstract:

A kit for temperature maintenance and shipment integrity of a cell culture is provided, including a well plate, a cell culture, culture media, an insulated receptacle, and a temperature maintenance element. The kit may include a heat release element. The well plate includes a plurality of wells. The cell culture is arranged within each of the plurality of wells of the well plate. Culture media is arranged within each of the plurality of wells of the well plate, where the culture media encapsulates the cell culture. The well plate is arranged within the insulated receptacle. The temperature maintenance element is arranged within the insulated receptacle. The heat release element is also arranged within the insulated receptacle.

US Patent:

20230102829, Mar 30, 2023

Filed:

Aug 31, 2021

Appl. No.:

17/463457

Inventors:

- OSAKA, JP
YONGJIN GONG - BELMONT MA, US
FENG LI - WINCHESTER MA, US
NICHOLAS E. BENCIVENGA - MALDEN MA, US
DAVID C. DALGARNO - BROOKLINE MA, US
ANNA KOHLMANN - WINCHESTER MA, US
WILLIAM C. SHAKESPEARE - SOUTHBOROUGH MA, US
RANNY M. THOMAS - SHARON MA, US
XIAOTIAN ZHU - NEWTON MA, US
ANGELA V. WEST - FRANKLIN MA, US
WILLMEN YOUNGSAYE - BOSTON MA, US
YUN ZHANG - ACTON MA, US
TIANJUN ZHOU - BELMOT MA, US

International Classification:

C07D 471/04
C07D 403/14
C07D 401/14
C07D 405/14
C07D 401/04
C07D 403/04
C07D 405/12
C07F 9/6558

Abstract:

Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.