Feng S Tian

US Patent:

7632823, Dec 15, 2009

Filed:

Dec 1, 2005

Appl. No.:

11/293629

Inventors:

Feng Tian - San Diego CA, US

Assignee:

Ambrx, Inc. - La Jolla CA

International Classification:

A61K 48/00
C07K 14/61
C07H 21/02
C12P 21/06

US Classification:

514 44, 435 691, 4353201, 43525233, 530399, 536 231

Abstract:

Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.

US Patent:

7632924, Dec 15, 2009

Filed:

Jun 17, 2005

Appl. No.:

11/155909

Inventors:

Ho Sung Cho - San Diego CA, US
Thomas O. Daniel - La Jolla CA, US
Troy E. Wilson - San Marino CA, US
Thomas P. Cujec - San Diego CA, US
Feng Tian - San Diego CA, US
Anna-Maria Hays - La Jolla CA, US
Bruce E. Kimmel - San Diego CA, US
Lillian Ho - San Diego CA, US

Assignee:

Ambrx, Inc. - La Jolla CA

International Classification:

C12P 21/08

US Classification:

5303873, 5303871, 5303877, 530350

Abstract:

Novel antigen-binding polypeptides (ABP) and uses thereof are provided.

US Patent:

7919591, Apr 5, 2011

Filed:

Oct 29, 2007

Appl. No.:

11/927283

Inventors:

Joseph Sheffer - Cardiff CA, US
Thea Norman - San Diego CA, US
Richard D. Dimarchi - Carmel IN, US
Anna-Maria A. Hays Putnam - San Diego CA, US
Feng Tian - San Diego CA, US
Stephanie Chu - San Diego CA, US
Denise Krawitz - San Diego CA, US
Ho Sung Cho - San Diego CA, US

Assignee:

Ambrx, Inc. - La Jolla CA

International Classification:

A61K 38/38
C07K 14/765
C12N 15/14

US Classification:

530363, 435 696, 4353201, 435325, 536 235

Abstract:

Modified human plasma polypeptides or Fc and uses thereof are provided.

US Patent:

8022186, Sep 20, 2011

Filed:

Oct 29, 2007

Appl. No.:

11/927139

Inventors:

Joseph Sheffer - Cardiff CA, US
Thea Norman - San Diego CA, US
Richard D. Dimarchi - Carmel IN, US
Anna-Maria A. Hays Putnam - San Diego CA, US
Feng Tian - San Diego CA, US
Stephanie Chu - San Diego CA, US
Denise Krawitz - San Diego CA, US
Ho Sung Cho - San Diego CA, US

Assignee:

Ambrx, Inc. - La Jolla CA

International Classification:

A61K 38/38
C07K 14/765
C12N 15/14

US Classification:

530363, 435 696, 4353201, 435325, 536 235

Abstract:

Modified human plasma polypeptides or Fc and uses thereof are provided.

US Patent:

8053560, Nov 8, 2011

Filed:

Oct 29, 2007

Appl. No.:

11/927247

Inventors:

Joseph Sheffer - Cardiff CA, US
Thea Norman - San Diego CA, US
Richard D. Dimarchi - Carmel IN, US
Anna-Maria A. Hays Putnam - San Diego CA, US
Feng Tian - San Diego CA, US
Stephanie Chu - San Diego CA, US
Denise Krawitz - Dan Diego CA, US
Ho Sung Cho - San Diego CA, US

Assignee:

Ambrx, Inc. - La Jolla CA

International Classification:

A61K 38/38
C07K 14/765
C12N 15/14

US Classification:

530363, 435 695, 4353201, 435325, 536 235

Abstract:

Modified human plasma polypeptides or Fc and uses thereof are provided.

US Patent:

8278418, Oct 2, 2012

Filed:

Sep 25, 2009

Appl. No.:

12/567627

Inventors:

Feng Tian - San Diego CA, US
Anna-Maria A. Hays Putnam - San Diego CA, US
Frank Song - San Diego CA, US
Stephanie Chu - San Diego CA, US
Joseph Sheffer - Cardiff CA, US
Richard S. Barnett - San Marcos CA, US
Marc E. Siladi - San Diego CA, US
Kyle Atkinson - San Diego CA, US
Darin Lee - San Diego CA, US
Peter C. Canning - Noblesville IN, US

Assignee:

Ambrx, Inc. - La Jolla CA

International Classification:

C07K 14/52
C07K 14/00

US Classification:

530351, 530350, 530402, 435440

Abstract:

Modified animal erythropoietin polypeptides and uses thereof are provide.

US Patent:

8341153, Dec 25, 2012

Filed:

Sep 8, 2009

Appl. No.:

12/555629

Inventors:

Feng Tian - Fremont CA, US

Assignee:

EMC Corporation - Hopkinton MA

International Classification:

G06F 7/00

US Classification:

707736, 707737, 707752, 707797

Abstract:

A computer readable storage medium includes executable instructions to order a binary tree using primary values and selected secondary values required to resolve a position in the binary tree. The remaining secondary values are in a do not care state. A new primary value is compared to the primary value at the root node of the binary tree. If necessary, a new secondary value is compared to the secondary value at the root node to determine whether the new primary value and the new secondary value or the value at the root node should be placed in a sorted list.

US Patent:

8367588, Feb 5, 2013

Filed:

Oct 11, 2006

Appl. No.:

11/992341

Inventors:

Meng-Lin Tsao - Merced CA, US
Feng Tian - San Diego CA, US
Peter Schultz - La Jolla CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

C40B 50/06

US Classification:

506 26

Abstract:

The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e. g. , an aryl-azide amino acid such as p-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2]cycloaddition reactions and Staudinger modifications.