Forrest J Agee

US Patent:

62088920, Mar 27, 2001

Filed:

Mar 26, 1999

Appl. No.:

9/277593

Inventors:

Forrest J. Agee - Albuquerque NM

Assignee:

The United States of America as represented by the Secretary of the Air
Force - Washington DC

International Classification:

A61N1/30

US Classification:

604 20

Abstract:

The ultra-wide band rf-enhanced chemotherapy for treatment of cancer and other intracellular diseases provides for increasing drug effectiveness. It also provides a means of treatment of inoperable cancers. The invention uses ultra-wide band short pulses to provide high electric field strength in diseased areas of a patient to induce electroporosis preferentially in the region to be treated by chemotherapy. The effect is to make the interiors of the cells in the affected region open to the chemotherapeutic agent. The treatment can be enhanced in its effectiveness thereby. It also enables treatment with reduced doses of the therapeutic agent and reduces side effects in other areas of the patient through the reduction of the total dosage. The invention makes specific use of the polarization of UWB fields and the very short duration of the pulsed electromagnetic fields induced into the region to be treated to minimize the absorbed rf energy associated with the treatment, making the heating of tissue negligible. The invention also makes it possible to select the size of the region being treated and in some embodiments to move the treated region electronically.

US Patent:

39900037, Nov 2, 1976

Filed:

Sep 17, 1975

Appl. No.:

5/614712

Inventors:

Forrest J. Agee - Alexandria VA
Huey A. Roberts - Alexandria VA

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

G01R 3108

US Classification:

324 52

Abstract:

A buried conduit shielding flaw detector is disclosed which provides a noestructive method for testing buried pipes, cables and conduits to locate and measure shielding flaws without the necessity of excavation. A sense wire is longitudinally disposed within the pipe and a current amplitude measuring device is connected on one end thereof. A loop antenna external to the buried pipe, is moved along, parallel to the pipe being tested. The antenna is connected to a voltage pulsing means for generating a pulse of electromagnetic radiation which will couple the pipe. When the antenna is moved to within the vicinity of a flaw in the pipe, the electromagnetic radiation from the antenna is coupled through the flaw to the sense wire within the pipe. A current pulse is thereby induced in the sense wire which is, in turn, detected by the current amplitude measuring device. The amplitude of the induced current is characteristic of the size of the flaw detected in the pipe.

US Patent:

62618318, Jul 17, 2001

Filed:

Mar 26, 1999

Appl. No.:

9/277596

Inventors:

Forrest J. Agee - Arlington VA

Assignee:

The United States of America as represented by the Secretary of the Air
Force - Washington DC

International Classification:

C12M 142

US Classification:

4352852

Abstract:

The ultra-wide band rf-enhanced chemotherapy for treatment of cancer and other intracellular diseases provides for increasing drug effectiveness. It also provides a means of treatment of inoperable cancers. The invention uses ultra-wide band short pulses to provide high electric field strength in diseased areas of a patient to induce electroporosis preferentially in the region to be treated by chemotherapy. The effect is to make the interiors of the cells in the affected region open to the chemotherapeutic agent. The treatment can be enhanced in its effectiveness thereby. It also enables treatment with reduced doses of the therapeutic agent and reduces side effects in other areas of the patient through the reduction of the total dosage. The invention makes specific use of the polarization of UWB fields and the very short duration of the pulsed electromagnetic fields induced into the region to be treated to minimize the absorbed rf energy associated with the treatment, making the heating of tissue negligible. It also uses a pulse repetition frequency slow enough to avoid wholesale killing of cells through osmotic shock.

US Patent:

60610344, May 9, 2000

Filed:

Nov 12, 1997

Appl. No.:

8/968181

Inventors:

Forrest J. Agee - Albuquerque NM
Jonathan P. Hull - Albuquerque NM

Assignee:

The United States of America, as represented by the Secretary of the Air
Force - Washington DC

International Classification:

H01Q 1300

US Classification:

343786

Abstract:

A means is disclosed for increasing the power and field strength radiated by a solid state switched array radiator such as those used for example in ultrawideband radar systems. The incorporation of a specially designed pulsed transmission line is designed to preserve very fast rising pulses produced in each of a number of Blumleins that are triggered simultaneously or with appropriate delay to provide at the output of the stack of Blumleins a voltage that is applied to an antenna radiating element.