Francis J Mcnally

US Patent:

56146183, Mar 25, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/484106

Inventors:

Bruce W. Stillman - Cold Spring Harbor NY
Stephen P. Bell - Cold Spring Harbor NY
Ryuji Kobayashi - Cold Spring Harbor NY
Jasper Rine - Moraga CA
Margit Foss - Durham NC
Francis J. McNally - Davis CA
Patricia Laurenson - San Francisco CA
Ira Herskowitz - Berkeley CA
Joachim Li - San Francisco CA
Kimberly Gavin - Cold Spring Harbor NY
Masumi Hidaka - Cold Spring Harbor NY

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY
The Regents of the University of California - Oakland CA

International Classification:

C07H 2102
C07M 2104
C12Q 168
C12P 1934

US Classification:

536 231

Abstract:

Origin of Replication Complex (ORC) genes, nucleic acids which encode ORC proteins and hybridization reagents, probes and primers capable of hybridizing with ORC genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant ORC protein, a natural intracellular ORC protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said ORC protein selectively binds said binding target; and detecting the presence or absence of specific binding of said ORC protein to said binding target.

US Patent:

55893414, Dec 31, 1996

Filed:

Jun 7, 1995

Appl. No.:

8/484105

Inventors:

Bruce W. Stillman - Cold Spring Harbor NY
Stephen P. Bell - Cold Spring Harbor NY
Ryuji Kobayashi - Cold Spring Harbor NY
Jasper Rine - Moraga CA
Margit Foss - Durham NC
Francis J. McNally - Davis CA
Patricia Laurenson - San Francisco CA
Ira Herskowitz - Berkeley CA
Joachim Li - San Francisco CA
Kimberly Gavin - Cold Spring Harbor NY
Masumi Hidaka - Cold Spring Harbor NY

Assignee:

Cold Spring Harbor Laboratory - Cold Spring Harbor NY
The Regents of the University of California - Oakland CA

International Classification:

C12Q 168
C12N 1500
C12N 115
C07K 1439

US Classification:

435 6

Abstract:

Origin of Replication Complex (ORC) genes, nucleic acids which encode ORC proteins and hybridization reagents, probes and primers capable of hybridizing with ORC genes and methods for screening chemical libraries for lead compounds for pharmacological agents useful in the diagnosis or treatment of disease associated undesirable cell growth are provided. An exemplary screen involves forming a mixture comprising a recombinant ORC protein, a natural intracellular ORC protein binding target, and a candidate pharmacological agent; incubating the mixture under conditions whereby, but for the presence of said candidate pharmacological agent, said ORC protein selectively binds said binding target; and detecting the presence or absence of specific binding of said ORC protein to said binding target.