Frederick L Cross

US Patent:

58612599, Jan 19, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/480912

Inventors:

James M. Roberts - Seattle WA
Motoaki Ohtsubo - Seattle WA
Andrew C. Koff - Seattle WA
Frederick Cross - New York NY

Assignee:

Fred Hutchinson Cancer Research - Seattle WA

International Classification:

G01N 3353

US Classification:

435 71

Abstract:

Methods are provided for determining in biological material the presence or amount human cyclin E polypeptide and/or cyclin E:cell division kinase complexes.

US Patent:

54497558, Sep 12, 1995

Filed:

Sep 16, 1992

Appl. No.:

7/947311

Inventors:

James M. Roberts - Seattle WA
Motoaki Ohtsubo - Seattle WA
Andrew C. Koff - Seattle WA
Frederick Cross - New York NY

Assignee:

Fred Hutchinson Cancer Research Center - Seattle WA

International Classification:

C07K 1300
C07H 0000

US Classification:

530350

Abstract:

Nucleic acid molecules capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 1 and 1185 of the human cyclin E cDNA sequence shown in FIG. 2. Polypeptides encoded by such nucleic acid molecules, and immunologic binding partners directed to such polypeptides.

US Patent:

58076980, Sep 15, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/488382

Inventors:

James M. Roberts - Seattle WA
Motoaki Ohtsubo - Seattle WA
Andrew C. Koff - Seattle WA
Frederick Cross - New York NY

Assignee:

Fred Hutchinson Cancer Research Center - Seattle WA

International Classification:

C12N 1500
C12N 1563
C12N 1585
C12Q 168
C07H 2104

US Classification:

435 691

Abstract:

Nucleic acid molecules capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 1 and 1185 of the human cyclin E cDNA sequence shown in FIG. 2. Polypeptides encoded by such nucleic acid molecules, and immunologic binding partners directed to such polypeptides.

US Patent:

57836612, Jul 21, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/522166

Inventors:

James M. Roberts - Seattle WA
Motoaki Ohtsubo - Seattle WA
Andrew C. Koff - Seattle WA
Frederick Cross - New York NY

Assignee:

Fred Hutchinson Cancer Research Center - Seattle WA

International Classification:

C07K 500
C07K 1400
C07H 2104

US Classification:

530300

Abstract:

Nucleic acid molecules capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 1 and 1185 of the human cyclin E cDNA sequence shown in FIG. 2. Polypeptides encoded by such nucleic acid molecules, and immunologic binding partners directed to such polypeptides.

US Patent:

56459998, Jul 8, 1997

Filed:

Jun 7, 1995

Appl. No.:

8/485859

Inventors:

James M. Roberts - Seattle WA
Motoaki Ohtsubo - Seattle WA
Andrew C. Koff - Seattle WA
Frederick Cross - New York NY

Assignee:

Fred Hutchinson Cancer Research Center - Seattle WA

International Classification:

C12Q 102
C12Q 148
G01N 3350

US Classification:

435 74

Abstract:

Whole cell or cell-free test systems for screening and identifying compounds that modulate or alter Cyclin E activity. Whole cell assays measure the G1 phase of cells in the presence or absence of the test compound. Additional whole cell or cell-free assays measure binding of cyclin E to a cell division kinase, measure cyclin E activity directly, or measure the cell division kinase activity directly in the presence or absence of the test compound.