Frederick Sachs

US Patent:

7125847, Oct 24, 2006

Filed:

Mar 26, 2003

Appl. No.:

10/397595

Inventors:

Frederick Sachs - Eden NY, US
Thomas Suchyna - Amherst NY, US
Janice Johnson - Salt Lake City UT, US

Assignee:

The Research Foundation of State University of New York at Buffalo - Amherst NY

International Classification:

A61K 38/00
A61K 38/16
C07K 14/00
C07K 1/00

US Classification:

514 12, 530300, 530324, 514 2

Abstract:

The present invention discloses a peptide of SEQ ID NO:2 and its variants that blocks stretch-activated ion channels. The peptide, designated as GsMTx-4, is present in the venom of the spider. The present invention also discloses a method of purifying the peptide GsMTx-4 from the spider venom and a method for inhibition of stretch activated ion channels in a cell. The cDNA sequence encoding the GsMTx-4 is also disclosed. This peptide and its variants can be used for the treatment of cardiac arrhythmias.

US Patent:

7259145, Aug 21, 2007

Filed:

Jul 7, 2005

Appl. No.:

11/176745

Inventors:

Frederick Sachs - Eden NY, US
Thomas Suchyna - Amherst NY, US
Phillip Gottlieb - Buffalo NY, US

Assignee:

The Research Foundation of State University of New York - Amherst NY

International Classification:

A61K 38/16
C07K 14/00

US Classification:

514 12, 530324, 530858

Abstract:

The present invention discloses a peptide of SEQ ID NO:1 and its variants that blocks stretch-activated ion channels. All amino acids in this peptide are D-amino acids. The peptide, designated as D-GsMTx4, is an enantiomer of a peptide GsMTX-4 present in the venom of the spider. The present invention also discloses a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias and other pathologies that involve alterations in mechanical stress.

US Patent:

7340944, Mar 11, 2008

Filed:

Aug 18, 2006

Appl. No.:

11/506970

Inventors:

Arthur Beyder - Kenmore NY, US
Frederick Sachs - Buffalo NY, US

International Classification:

G01B 5/28

US Classification:

73105

Abstract:

A device having an oscillator such as a sensor for use in an atomic force microscope. A pair of co-axial members interconnect support structure and the oscillator for torsionally suspending the oscillator. The co-axial members are portions of a layer of silicon nitride or other material that is connected to the oscillator and support structure, which are composed of silicon or other material. A process for making a device which includes an oscillator, which includes depositing on silicon or other first material a layer of silicon nitride or other second material, forming in the first material a support structure and the oscillator, including applying an etchant which is selective for the first material to etch all the way through the first material and leave the second material substantially unetched to thereby form the at least one flexible hinge of the second material.

US Patent:

7533561, May 19, 2009

Filed:

Aug 18, 2006

Appl. No.:

11/506757

Inventors:

Arthur Beyder - Kenmore NY, US
Frederick Sachs - Buffalo NY, US

International Classification:

G01B 5/28

US Classification:

73105

Abstract:

A device such as a sensor for use in an atomic force microscope. The device comprises a first oscillator, a second oscillator, a pair of first co-axial members interconnecting the first and second oscillators for torsionally suspending the first oscillator, a support structure, and a pair of second co-axial members whose axis is orthogonal to an axis of the first co-axial members and which interconnect the second oscillator and the support structure for torsionally suspending the second oscillator.

US Patent:

7607344, Oct 27, 2009

Filed:

Apr 23, 2007

Appl. No.:

11/789044

Inventors:

Frederick Sachs - Buffalo NY, US

International Classification:

G01B 5/28
G01N 13/16

US Classification:

73105

Abstract:

A scanner which includes a gradient index lens for passing and focusing beams from a radiation emitter to a cantilevered member reflective surface of a probe and from the reflective surface to a radiation detector. The lens also serves as a mechanical support for attachment of the radiation emitter and the radiation detector and is also attached to a support for the cantilevered member. The resulting fixed positions of the radiation emitter and the radiation detector relative to the reflective cantilevered member surface allows the scanner to be compact and factory focally alignable.

US Patent:

7869972, Jan 11, 2011

Filed:

Jun 5, 2008

Appl. No.:

12/602884

Inventors:

Stephen Besch - Buffalo NY, US
Frederick Sachs - Buffalo NY, US

Assignee:

The Research Foundation of State University of New York - Amherst NY

International Classification:

G01R 35/00

US Classification:

702106

Abstract:

The method and system of the present invention uses synchronous rectification and frequency domain analysis to remove the need for calibration of the A/D and D/A components. It is applicable to any sensor based measurement in which either the sensor can be excited with an AC voltage or current, or in which the signal can be modulated with an AC voltage or current.

US Patent:

8372600, Feb 12, 2013

Filed:

Feb 25, 2009

Appl. No.:

12/380232

Inventors:

Frederick Sachs - Eden NY, US
Zonglu Hua - Williamsville NY, US
Stephen Besch - Buffalo NY, US
Harsh Deep Chopra - Williamsville NY, US
Philip Gottlieb - Buffalo NY, US

Assignee:

The Research Foundation of State University of New York - Amherst NY

International Classification:

C12Q 1/06

US Classification:

435 39, 435 405, 4352871

Abstract:

A method and apparatus for measuring changes in cell volume generally includes introducing cells into a chamber having a volume between 2 and 100 times the volume of the introduced cell. A first electrically conductive extracellular fluid is introduced into the chamber and a current is applied. The voltage induced by said current flow is measured. The first fluid is exchanged with a second electrically conductive extracellular fluid and a current is applied. The voltage induced by said current flow is measured. The first induced voltage result and the second induced voltage result are used in conjunction with known voltages induced by such current flows to monitor changes in the volume corresponding to fluid flow between the cell and an extracellular fluid.

US Patent:

20020077286, Jun 20, 2002

Filed:

Apr 6, 2001

Appl. No.:

09/827814

Inventors:

Frederick Sachs - Eden NY, US
Janice Johnson - Salt Lake City UT, US
Thomas Suchyna - Amherst NY, US

International Classification:

A61K038/17
C07K014/435

US Classification:

514/012000, 530/350000

Abstract:

The present invention discloses a 35 amino acid peptide (SEQ ID NO: 1) that blocks stretch-activated ion channels. The peptide, designated as GsMTx-4, is present in the venom of the spider The present invention also discloses a method of purifying the peptide GsMTx-4 from the spider venom and a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias.