Miodrag G Radulovacki

US Patent:

6555564, Apr 29, 2003

Filed:

Nov 6, 2001

Appl. No.:

09/914900

Inventors:

Miodrag Radulovacki - Chicago IL
David W. Carley - Evanston IL

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A61K 31425

US Classification:

514367

Abstract:

The present invention relates generally to pharmacological methods for the prevention or amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess glutamate-related and/or glycine-related pharmacological activity or that modulate the release of either glutamate or glycine (or both) from nerve terminals with the central nervous system.

US Patent:

6727242, Apr 27, 2004

Filed:

Dec 14, 2001

Appl. No.:

10/016901

Inventors:

Miodrag Radulovacki - Chicago IL
David W. Carley - Evanston IL

Assignee:

The Board of Trustees of the University of Illinois - Chicago IL

International Classification:

A61K 3155

US Classification:

51421402, 514220, 514259, 514288, 514299, 514325

Abstract:

The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity.

US Patent:

6974814, Dec 13, 2005

Filed:

Mar 27, 2003

Appl. No.:

10/400265

Inventors:

Miodrag Radulovacki - Chicago IL, US
David W. Carley - Evanston IL, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A61K031/498
A61K031/445
A61K031/35
A61K031/13

US Classification:

514249, 514315, 514453, 514662

Abstract:

The present invention relates to pharmacological methods for the prevention or amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess glutamate-related and/or glycine-related pharmacological activity or that modulate the release of glutamate, glycine, or both from nerve terminals with the central nervous system.

US Patent:

7160898, Jan 9, 2007

Filed:

Oct 31, 2002

Appl. No.:

10/285277

Inventors:

Miodrag Radulovacki - Chicago IL, US
David W. Carley - Evanston IL, US

Assignee:

Board of Trustees of The University of Illinois - Urbana IL

International Classification:

A61K 31/439
A61K 31/4375
A61K 31/343
A61K 31/551

US Classification:

514304, 514306, 514450, 514221

Abstract:

The present invention relates to pharmacological methods for the amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity.

US Patent:

7705039, Apr 27, 2010

Filed:

Apr 8, 2002

Appl. No.:

10/472136

Inventors:

David W. Carley - Evanston IL, US
Miodrag Radulovacki - Chicago IL, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A61K 31/352
A61K 31/164

US Classification:

514455, 514627

Abstract:

A method of ameliorating a sleep-related breathing disorder via administration of at least one cannabimimetic agent, such as oleamide or ΔTHC, to an individual in need of treatment.

US Patent:

8053413, Nov 8, 2011

Filed:

Jun 6, 2006

Appl. No.:

11/916563

Inventors:

David W. Carley - Evanston IL, US
Miodrag Radulovacki - Chicago IL, US

Assignee:

The Board of Trustees of the University of Illinois - Chicago IL

International Classification:

A61K 38/00
A61K 31/675
A61P 25/00
A01N 43/02
A01N 43/16

US Classification:

514 177, 514449, 514459, 514 79

Abstract:

The present invention relates to a method for preventing or ameliorating a sleep-related breathing disorder. The method involves the use of one or a combination of cholecystokinin (CCK) receptor antagonists.

US Patent:

8076315, Dec 13, 2011

Filed:

Oct 13, 2006

Appl. No.:

12/090131

Inventors:

David W. Carley - Evanston IL, US
Miodrag Radulovacki - Chicago IL, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A61K 31/66
A61P 25/00
A01N 43/00

US Classification:

514 75, 51421101

Abstract:

This invention is directed to methods for preventing or ameliorating sleep-related breathing disorders. The method comprises administration to a patient in need thereof an effective dose of one or a combination of prostanoid receptor antagonists (eg. ramatroban, ifetroban, diphloretin, phosphate, polyphloretin phosphate, seratrodast, SC19220). The prostanoid receptor antagonist or combination of prostanoid receptor antagonists can be administered in conjunction with one or more serotonin receptor agonists, one or more cannabinoids receptor agonists, one or more serotonin reuptake inhibitors, one or more noradrenalin reuptake inhibitors, a combination of reuptake inhibitors, an inhibitor of prostanoid synthesis, or any combination of the foregoing.

US Patent:

8207230, Jun 26, 2012

Filed:

Dec 4, 2009

Appl. No.:

12/631359

Inventors:

David W. Carley - Evanston IL, US
Miodrag Radulovacki - Chicago IL, US

Assignee:

The Board of Trustees of the University of Illinois - Urbana IL

International Classification:

A61K 31/16
A61K 31/165

US Classification:

514627

Abstract:

The present invention relates generally to pharmacological methods for the amelioration of sleep-related breathing disorders via administration of inhibitors of endocannabinoid membrane transport and combinations thereof.