Gail U Arnold

US Patent:

55411002, Jul 30, 1996

Filed:

Sep 12, 1994

Appl. No.:

8/304635

Inventors:

Edward V. Arnold - New Brunswick NJ
Gail F. Arnold - New Brunswick NJ

Assignee:

Rutgers University - New Brunswick NJ

International Classification:

C12N 701
A61K 3912

US Classification:

4352351

Abstract:

Recombinant chimeric human rhinovirus and method for stimulation of a specific immune response. Design considerations, methods, and examples are described. Chimeric rhinoviruses can be used as vaccines and for a variety of other immunotechnological applications.

US Patent:

57143749, Feb 3, 1998

Filed:

Mar 17, 1995

Appl. No.:

8/406347

Inventors:

Edward V. Arnold - New Brunswick NJ
Gail Ferstandig Arnold - New Brunswick NJ

Assignee:

Rutgers University - Piscataway NJ

International Classification:

C12N 701
A67K 3912

US Classification:

4352351

Abstract:

Various novel recombinant chimeric human rhinoviruses are disclosed, including viruses comprising human rhinovirus 14 into which chimeric regions derived from influenza HA, poliovirus and HIV-1 have been incorporated. Chimeric human rhinoviruses are particularly advantageous as they are only mildly pathogenic, have numerous potential serotypes and can elicit significant mucosal and serum immunological response. Design considerations, methods, and examples are described. The chimeric rhinoviruses can be used as vaccines and for a variety of other immunotechnological applications including passive immunization, immunodiagnostic testing and antigenicity and immunogenicity studies.