Gang Chen

US Patent:

7531166, May 12, 2009

Filed:

Jun 21, 2006

Appl. No.:

11/472813

Inventors:

Linda Masat - Oakland CA, US
Mary Haak-Frendscho - Newark CA, US
Gang Chen - San Diego CA, US
Arnold Horwitz - San Leandro CA, US
Marina Roell - Concord CA, US

Assignee:

XOMA Technology, Ltd. - Berkely CA

International Classification:

C07K 16/24
A61K 39/395

US Classification:

424 852, 5303871, 5303881

Abstract:

An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.

US Patent:

7582742, Sep 1, 2009

Filed:

Jul 18, 2008

Appl. No.:

12/218914

Inventors:

Linda Masat - Oakland CA, US
Mary Haak-Frendscho - Newark CA, US
Gang Chen - San Diego CA, US
Arnold Horwitz - San Leandro CA, US
Marina Roell - Concord CA, US

Assignee:

XOMA Technology Ltd. - Berkeley CA

International Classification:

C12N 5/10
C12N 15/13
C12N 15/63

US Classification:

536 2353, 435325, 4352523, 4353201

Abstract:

Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1β binding antibody or IL-1β binding fragment thereof. An IL-1β binding antibody or IL-1β binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO:28, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1β binding polypeptide is provided. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.

US Patent:

7695717, Apr 13, 2010

Filed:

Jul 18, 2008

Appl. No.:

12/218997

Inventors:

Linda Masat - Oakland CA, US
Mary Haak-Frendscho - Newark CA, US
Gang Chen - San Diego CA, US
Arnold Horwitz - San Leandro CA, US
Marina Roell - Concord CA, US

Assignee:

XOMA Technology Ltd. - Berkeley CA

International Classification:

A61K 39/395

US Classification:

4241411, 4241451, 4241391

Abstract:

Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1β binding antibody or IL-1β binding fragment thereof. An IL-1β binding antibody or IL-1β binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO:28, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1β binding polypeptide is provided. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.

US Patent:

7744865, Jun 29, 2010

Filed:

May 11, 2009

Appl. No.:

12/463741

Inventors:

Linda Masat - Walnut Creek CA, US
Mary Haak-Frendscho - Newark CA, US
Arnold H. Horwitz - San Leandro CA, US
Gang Chen - San Diego CA, US
Marina Roell - Concord CA, US

Assignee:

Xoma Technology Ltd. - Berkeley CA

International Classification:

C07K 16/24
A61K 39/395

US Classification:

424 852, 5303871, 5303881

Abstract:

An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 8 and SEQ ID NO: 9, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.

US Patent:

7744866, Jun 29, 2010

Filed:

May 11, 2009

Appl. No.:

12/463844

Inventors:

Linda Masat - Walnut Creek CA, US
Mary Haak-Frendscho - Newark CA, US
Arnold H. Horwitz - San Leandro CA, US
Gang Chen - San Diego CA, US
Marina Roell - Concord CA, US

Assignee:

XOMA Technology Ltd. - Berkeley CA

International Classification:

C07K 16/24
A61K 39/395

US Classification:

424 852, 5303871, 5303881

Abstract:

An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 26 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.

US Patent:

7829093, Nov 9, 2010

Filed:

May 11, 2009

Appl. No.:

12/464006

Inventors:

Linda Masat - Walnut Creek CA, US
Mary Haak-Frendscho - Newark CA, US
Arnold H. Horwitz - San Leandro CA, US
Gang Chen - San Diego CA, US
Marina Roell - Concord CA, US

Assignee:

Xoma Technology Ltd. - Berkeley CA

International Classification:

A61K 39/395

US Classification:

4241451, 4241301, 4241391, 4241411, 514885

Abstract:

Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1β binding antibody or IL-1β binding fragment thereof. An IL-1β binding antibody or IL-1β binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO: 15 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.

US Patent:

7829094, Nov 9, 2010

Filed:

May 11, 2009

Appl. No.:

12/464061

Inventors:

Linda Masat - Walnut Creek CA, US
Mary Haak-Frendscho - Newark CA, US
Arnold H. Horwitz - San Leandro CA, US
Gang Chen - San Diego CA, US
Marina Roell - Concord CA, US

Assignee:

Xoma Technology Ltd. - Berkeley CA

International Classification:

A61K 39/395

US Classification:

4241451, 4241301, 4241391, 4241411, 514885

Abstract:

Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1β binding antibody or IL-1β binding fragment thereof. An IL-1β binding antibody or IL-1β binding fragment thereof is provided comprising the amino acid sequence of SEQ ID NO: 15 and SEQ ID NO: 11, and related nucleic acids, vectors, cells, and compositions, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.

US Patent:

7943121, May 17, 2011

Filed:

May 12, 2009

Appl. No.:

12/464381

Inventors:

Linda Masat - Walnut Creek CA, US
Mary Haak-Frendscho - Newark CA, US
Arnold H. Horwitz - San Leandro CA, US
Gang Chen - San Diego CA, US
Marina Roell - Concord CA, US

Assignee:

XOMA Technology Ltd. - Berkeley CA

International Classification:

C07K 16/24
A61K 39/395

US Classification:

424 852, 5303871, 5303881

Abstract:

An IL-1β binding antibody or IL-1β binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL-1β binding polypeptide. IL-1β binding antibodies or IL-1β binding fragments thereof are provided which have desirable affinity and potency.