Gary M Blackburn

US Patent:

6686150, Feb 3, 2004

Filed:

Jul 20, 2000

Appl. No.:

09/621275

Inventors:

Gary Blackburn - Glendora CA
Bruce D. Irvine - Glendora CA
Jon Faiz Kayyem - Pasadena CA
Robert H. Terbrueggen - Manhattan Beach CA

Assignee:

Clinical Micro Sensors, Inc. - Pasadena CA

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 435 912, 536 231, 536 253

Abstract:

The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the nucleic acid, either directly or indirectly, to allow electronic detection of the ETM using an electrode.

US Patent:

6761816, Jul 13, 2004

Filed:

Mar 8, 2000

Appl. No.:

09/520477

Inventors:

Gary Blackburn - Glendora CA
Stephen E. Creager - Central SC
Scott Fraser - La Canada CA
Bruce D. Irvine - Glendora CA
Thomas J. Meade - Altadena CA
Stephen D. OConnor - Pasadena CA
Robert H. Terbrueggen - Manhattan Beach CA
Jost G. Vielmetter - Pasadena CA
Thomas W. Welch - Pasadena CA

Assignee:

Clinical Micro Systems, Inc. - Pasadena CA

International Classification:

G01N 27327

US Classification:

2057775, 20440301

Abstract:

The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.

US Patent:

6875619, Apr 5, 2005

Filed:

May 17, 2001

Appl. No.:

09/861171

Inventors:

Gary Blackburn - Glendora CA, US

Assignee:

Motorola, Inc. - Schaumburg IL

International Classification:

G01N033/558

US Classification:

436514, 435 6, 435 71, 4352871, 4352872, 436518, 436524, 436527, 436531, 436805

Abstract:

The present invention is directed to a variety of microfluidic devices with configurations including the use of biochannels or microchannels comprising arrays of capture binding ligands to capture target analytes in samples. The invention provides microfluidic cassettes or devices that can be used to effect a number of manipulations on a sample to ultimately result in target analyte detection or quantification.

US Patent:

7087148, Aug 8, 2006

Filed:

Nov 13, 2000

Appl. No.:

09/712792

Inventors:

Gary Blackburn - Glendora CA, US
Jost G. Vielmetter - Pasadena CA, US
Jon Faiz Kayyem - Pasadena CA, US

Assignee:

Clinical Micro Sensors, Inc. - Pasedena CA

International Classification:

G01N 27/327
G01N 21/447
G01N 27/453

US Classification:

205452, 20440306, 205603, 205461, 205612

Abstract:

The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.

US Patent:

7172897, Feb 6, 2007

Filed:

Nov 5, 2001

Appl. No.:

09/993342

Inventors:

Gary Blackburn - Glendora CA, US
Hau H. Duong - Los Angeles CA, US
Piotr Grodzinski - Chandler AZ, US
Jon Faiz Kayyem - Pasadena CA, US
Stephen D. O'Connor - Pasadena CA, US
Robert Pietri - Pasadena CA, US
Robert Henry Terbrueggen - Manhattan Beach CA, US
Frederic Zenhausern - Fountain Hills AZ, US
Gary T. Olsen - La Crescenta CA, US

Assignee:

Clinical Micro Sensors, Inc. - Pasadena CA

International Classification:

C12M 1/34

US Classification:

4352872, 20440302, 20440303, 204406

Abstract:

The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.

US Patent:

7312087, Dec 25, 2007

Filed:

Jan 11, 2001

Appl. No.:

09/760384

Inventors:

Hau H. Duong - Los Angeles CA, US
Gary Blackburn - Glendora CA, US
Jon F. Kayyem - Pasadena CA, US
Stephen D. O'Connor - Pasadena CA, US
Gary T. Olsen - La Cresenta CA, US
Robert Pietri - Pasadena CA, US
Robert H. Terbrueggen - Manhattan Beach CA, US

Assignee:

Clinical Micro Sensors, Inc. - Pasadena CA

International Classification:

C12Q 1/68
G01N 15/06
G01N 33/00
G01N 33/48
G01N 35/00

US Classification:

436149, 422 50, 422 681, 422 8201, 422 8205, 436 43, 436 63, 436 64, 436 66, 436150, 205775, 205792, 2057935, 204164, 204461, 204193, 204194, 204400, 20440301, 20440302, 20440303, 204406, 204407

Abstract:

The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips include a substrate, the substrates including an array of detection electrodes, each electrode including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contracts, detecting current as an indication of the presence of the labels on the first biochip, and detecting current as an indication of the presence of the labels on the first second biochip. The devices and method may be used with multiple cartridges comprising biochips comprising arrays, such as nucleic acid arrays, and allow for high throughput analysis of samples.

US Patent:

7655129, Feb 2, 2010

Filed:

Apr 12, 2004

Appl. No.:

10/823503

Inventors:

Gary Blackburn - Glendora CA, US
Stephen E. Creager - Central SC, US
Scott Fraser - La Canada CA, US
Bruce D. Irvine - Glendora CA, US
Thomas J. Meade - Willmette IL, US
Stephen J. O'Connor - Pasadena CA, US
Robert H. Terbrueggen - Manhattan Beach CA, US
Jost G. Vielmetter - Altadena CA, US
Thomas W. Welch - Pasadena CA, US

Assignee:

Osmetech Technology Inc. - Pasadena CA

International Classification:

G01N 27/327

US Classification:

2057775, 204452

Abstract:

The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.

US Patent:

20020177135, Nov 28, 2002

Filed:

Jul 11, 2001

Appl. No.:

09/904175

Inventors:

Hau Doung - Los Angeles CA, US
Gary Blackburn - Glendora CA, US
Jon Kayyem - Pasadena CA, US
Stephen O'Connor - Pasadena CA, US
Gary Olsen - La Cresenta CA, US
Robert Pietri - Pasadena CA, US
Nathan Swami - South Pasadena CA, US
Robert Terbrueggen - Manhattan Beach CA, US

International Classification:

C12Q001/68
C12M001/34

US Classification:

435/006000, 435/287200

Abstract:

The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.