J. David Port - Denver CO Gary Brewer - Winston-Salem NC
Assignee:
Wake Forest University - Winston-Salem NC University Technology Corporation - Boulder CO
International Classification:
G01N 3353
US Classification:
435 6, 435 71, 435 794, 436504, 436501
Abstract:
Methods are disclosed for treating heart failure. Methods are disclosed for screening pharmacologicals that inhibit the down-regulatory activity of AUF1 or AUF1-related polypeptide for -adrenergic activity. Methods are disclosed for treating a patient with a high level of the AUF1 or AUF1-related gene.
Dna Sequence Encoding A Polypeptide With Anti-Tumor Properties
The invention relates to the DNA sequence encoding the AUF1 polypeptide, or fragments thereof. Also, the invention relates to the AUF1 polypeptide itself or fragments thereof. Methods are disclosed for detecting the severity of neoplastic transformation. Methods are disclosed for detecting pharmacologicals that enhance the anti-tumor activity of AUF1. Methods are disclosed for treating a patient with a low level of the AUF1 gene.
J. David Port - Denver CO Gary Brewer - Winston-Salem NC
Assignee:
Regents of the University of Colorado - Boulder CO Wake Forest University - Winston-Salem NC
International Classification:
G01N 3353 G01N 33543 C12Q 168 C07H 2104
US Classification:
435 6
Abstract:
Methods are disclosed for detecting and treating heart failure which are based on the down-regulatory activity of the cytoplasmic RNA-binding polypeptide, AUF1 (A+U-rich element RNA-binding/degradation Factor) toward. beta. -adrenergic receptors. Methods are disclosed for detecting pharmacologicals that inhibit the down-regulatory activity of AUF1 polypeptide for. beta. -adrenergic activity. Methods are disclosed for treating a patient with a high level of the AUF1 gene.
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