Gary William Litman

US Patent:

7038030, May 2, 2006

Filed:

Apr 16, 2003

Appl. No.:

10/417476

Inventors:

Gary W. Litman - Gulfport FL, US
Noel A. Hawke - Durham NC, US
Jeffrey A. Yoder - St. Petersburg FL, US
Donna D. Eason - Bradenton FL, US

Assignee:

University of South Florida - Tampa FL

International Classification:

C07H 21/02
C07H 21/04

US Classification:

536 231, 536 243, 536 2433, 4242651

Abstract:

The subject invention provides polynucleotide sequences, designated BIVM, and transcriptional/translational products obtained from the polynucleotide sequences of the invention. The subject invention also provides polynucleotide and polypeptide sequences provided by SEQ ID NOs:1–28. Also provided are methods of detecting the presence of BIVM nucleic acids or polypeptides in samples suspected of containing BIVM genes, BIVM transcriptional products, or BIVM translational products. These methods are also useful for the detection of BIVM orthologs. Other embodiments provide polypeptide and/or nucleic acid vaccines for the induction of an immune response to in an individual. Kits for detecting the presence of BIVM genes, orthologs thereof, BIVM polypeptides, or BIVM transcriptional products are also provided.

US Patent:

7112434, Sep 26, 2006

Filed:

May 2, 2002

Appl. No.:

10/138998

Inventors:

John P. Cannon - St. Petersburg FL, US
Robert N. Haire - Clearwater FL, US
Gary W. Litman - Gulfport FL, US

Assignee:

University of South Florida - Tampa FL

International Classification:

C12N 15/00
C12N 15/64
C12N 15/66
C07H 21/02

US Classification:

4353201, 435 914, 435 9141, 536 231, 536 241

Abstract:

The subject invention concerns novel vectors for the rapid and robust selection for cDNA sequences that encode secreted or membrane-bound proteins. The invention also pertains to methods for cloning secreted or membrane-bound proteins, including proteins encoded by novel members of gene families.

US Patent:

7553491, Jun 30, 2009

Filed:

May 2, 2006

Appl. No.:

11/415536

Inventors:

Gary W. Litman - Gulfport FL, US
Noel A. Hawke - Durham NC, US
Jeffrey A. Yoder - St. Petersburg FL, US
Donna D. Eason - Bradenton FL, US

Assignee:

University of South Florida - Tampa FL

International Classification:

A61K 39/002

US Classification:

4241911, 4242651, 4353201

Abstract:

The subject invention provides polynucleotide sequences, designated BIVM, and transcriptional/translational products obtained from the polynucleotide sequences of the invention. The subject invention also provides polynucleotide and polypeptide sequences provided by SEQ ID NOs:1-28. Also provided are methods of detecting the presence of BIVM nucleic acids or polypeptides in samples suspected of containing BIVM genes, BIVM transcriptional products, or BIVM translational products. These methods are also useful for the detection of BIVM orthologs. Other embodiments provide polypeptide and/or nucleic acid vaccines for the induction of an immune response to in an individual. Kits for detecting the presence of BIVM genes, orthologs thereof, BIVM polypeptides, or BIVM transcriptional products are also provided.

US Patent:

20070111283, May 17, 2007

Filed:

Aug 31, 2006

Appl. No.:

11/514476

Inventors:

John Cannon - St. Petersburg FL, US
Robert Haire - Clearwater FL, US
Gary Litman - Gulfport FL, US

International Classification:

C12P 21/06
C12N 9/16
C12N 9/80
C12N 1/21
C07H 21/04
C12N 15/74

US Classification:

435069100, 435196000, 435228000, 435471000, 435252300, 536023200

Abstract:

The subject invention concerns novel vectors for the rapid and robust selection for cDNA sequences that encode secreted or membrane-bound proteins. The invention also pertains to methods for cloning secreted or membrane-bound proteins, including proteins encoded by novel members of gene families.

US Patent:

20070172871, Jul 26, 2007

Filed:

Jan 19, 2007

Appl. No.:

11/655668

Inventors:

Larry Dishaw - Bradenton FL, US
Gary Litman - Gulfport FL, US
Robert Haire - Clearwater FL, US

International Classification:

C40B 30/06
C40B 40/08

US Classification:

435006000

Abstract:

The present invention concerns a method for profiling variations in gene transcription (e.g., variable RNA processing) from complex and/or unknown genomic regions. Rather than screening EST or cDNA libraries for transcripts of interest, the method of the invention involves the reverse, i.e., using the genetic locus responsible for the gene product as a tool to capture representatives from this (specific) region.

US Patent:

20090232824, Sep 17, 2009

Filed:

Apr 15, 2009

Appl. No.:

12/423855

Inventors:

GARY W. LITMAN - Gulfport FL, US
Noel A. Hawke - Durham NC, US
Jeffrey A. Yoder - St. Petersburg FL, US
Donna D. Eason - Bradenton FL, US

Assignee:

University of South Florida - Tampa FL

International Classification:

A61K 39/395
A61K 39/00
C07K 14/00
C07K 16/00

US Classification:

4241391, 4241851, 530350, 5303879

Abstract:

The subject invention provides polynucleotide sequences, designated BIVM, and transcriptional/translational products obtained from the polynucleotide sequences of the invention. The subject invention also provides polynucleotide and polypeptide sequences provided by SEQ ID NOs: 1-28. Also provided are methods of detecting the presence of BIVM nucleic acids or polypeptides in samples suspected of containing BIVM genes, BIVM transcriptional products, or BIVM translational products. These methods are also useful for the detection of BIVM orthologs. Other embodiments provide polypeptide and/or nucleic acid vaccines for the induction of an immune response to in an individual. Kits for detecting the presence of BIVM genes, orthologs thereof, BIVM polypeptides, or BIVM transcriptional products are also provided.

US Patent:

62844962, Sep 4, 2001

Filed:

Jan 2, 1998

Appl. No.:

9/165934

Inventors:

Gary W. Litman - Clearwater FL
Noel A. Hawke - St. Petersburg FL
Robert N. Haire - Clearwater FL
Scott J. Strong - Keene NH

Assignee:

University of South Florida - Tampa FL

International Classification:

C12P 1934

US Classification:

435 912

Abstract:

A DNA expression vector for positively selecting in-frame or out-of-reading-frame mutations in DNA sequences to be tested comprising a promotor operatively linked to an expressible reporter gene through a linkage sequence is disclosed. The linkage sequence includes at least two restriction sites and an engineered frameshift mutation. In an embodiment the frameshift is established by complementary sequences SEQ ID Nos:1 and 2. The expressible reporter gene is expressed as a fusion product including a green fluorescent protein and the promoter can be lacZ and inducible in E. coli.