Gary S O'Brien

US Patent:

20140051672, Feb 20, 2014

Filed:

Aug 7, 2013

Appl. No.:

13/960917

Inventors:

Atwood Kim CHEUNG - Arlington MA, US
Donovan Noel CHIN - Lexington MA, US
Natalie DALES - Arlington MA, US
Aleem FAZAL - Burlington MA, US
Timothy Brian HURLEY - Boston MA, US
John KERRIGAN - Wakefield MA, US
Gary O'BRIEN - Maynard MA, US
Lei SHU - Woburn MA, US
Robert SUN - Natick MA, US
Moo Je SUNG - Belmont MA, US

International Classification:

C07D 401/12
A61K 45/06
C07D 409/14
C07D 401/14
A61K 31/502
C07D 413/14
C07D 417/14
A61K 31/5377
C07D 403/12
A61K 31/551
C07D 471/08
C07D 471/10
C07D 471/04
C07D 403/14
C07D 403/10
C07D 487/10
C07D 487/04
C07D 237/20
C07D 401/04
C07D 405/14
A61K 31/506
A61K 31/501

US Classification:

5142102, 544238, 51425203, 51425204, 514249, 514248, 544237, 544114, 5142365, 51425205, 51425202, 514218, 540575, 544230, 51425206

Abstract:

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

US Patent:

61684368, Jan 2, 2001

Filed:

Jun 18, 1997

Appl. No.:

8/877916

Inventors:

Gary O'Brien - Glendale CA

International Classification:

A61C 800

US Classification:

433173

Abstract:

A universal dental implant abutment system is provided which includes an abutment collar and a fixation screw. The abutment collar has a proximal end portion adapted for fixation to a dental prosthesis and a distal end portion adapted for coupling with an implant body. The fixation screw is disposed within a longitudinal bore of the abutment collar and has a threaded distal end for securement to the implant body. The fixation screw has a head portion formed on a proximal end thereof, the head portion having a longitudinally directed bore formed therein. The longitudinal bore of the head of the fixation screw is formed with two longitudinally spaced sections. One section has a non-circular cross-sectional contour adapted for receiving a driving tool therein. The other section has internal threads formed therein adapted for threaded engagement with a retention fastener of a prosthesis.

US Patent:

55271839, Jun 18, 1996

Filed:

Aug 9, 1994

Appl. No.:

8/288278

Inventors:

Gary O'Brien - Glendale CA

Assignee:

Collaborative Enterprises, Inc. - Glendale CA

International Classification:

A61C 800

US Classification:

433174

Abstract:

An endosseous implant body for affixing an orthopedic prosthesis into bone is provided. The implant body generally has at least four segments disposed proximate to a coronal end of the implant body. Each segment consists of a frustro-conical compression moiety and a frustro-conical tension moiety. The angles of incidence and the surface areas of the compression moieties are chosen so that, when the body is implanted into bone and a lateral force is applied to the coronal end of the body, that portion of the lateral force which is exerted by the compression moiety of each segment against the surrounding bone is greater than that portion of the lateral force which is exerted by the compression moiety of an adjacent segment disposed more proximate to the coronal end. Likewise, the angles of incidence and the surface areas of the tension moieties are chosen so that, when the body is implanted into bone and a lateral force is applied to the coronal end of the body, that portion of the lateral force which is exerted by the tension moiety of each segment against the surrounding bone is less than that portion of the lateral force which is exerted by the tension moiety of an adjacent segment disposed more proximate to the coronal end. The implant body of the invention has been found to produce a stable implant sight for orthopedic prostheses, especially dental prostheses.

US Patent:

54357233, Jul 25, 1995

Filed:

Aug 18, 1993

Appl. No.:

8/108869

Inventors:

Gary R. O'Brien - Glendale CA

International Classification:

A61C 800

US Classification:

433174

Abstract:

An endosseous dental implant system comprises a root formed, mechanically retained base and an intimate, inter-locking threaded coronal attachment. The root formed base is comprised of a self-locking, externally threaded, tapered shell, and an anti-rotational internally threaded, countersunk plug which is permanently attached below the coronal surface of the shell, thus forming a single unit. Internally, the coronal portion of the shell has a downward tapered bevel for locking the anti-rotational coronal attachment to the base once attached via the internal threads of the permanently connected countersunk plug. Self-tapping threads are incorporated into the apex of the root formed base for easy insertion and immediate locking with the osteotomy. Downward from the coronal portion through the midsection of the root formed base is a specially designed stress distributing thread for uniform loading through the implant site. Finally, to simulate the physiological conditions, the implant system is manufactured from a material that closely replicates the natural dentition.

US Patent:

56791950, Oct 21, 1997

Filed:

Sep 1, 1995

Appl. No.:

8/522947

Inventors:

John O'Dwyer - Lynn MA
Richard Sangster - Greenville RI
Gary O'Brien - Rockland MA

Assignee:

John O'Dwyer - Lynn MA

International Classification:

B65H 6906

US Classification:

156159

Abstract:

An input festoon is provided in a web supply apparatus for automatically splicing a relatively stiff web of material such a liner board for making corrugated board. The input festoon includes a dancer roll which is movable along a track to allow storage of a ready web as the ready web is pre-accelerated by an accelerator roll to a running speed prior to creation of a splice at a splice head. Tail grab sensors are mounted on the apparatus above the web between the input roll and the splice head adjacent the input roll. The tail grab sensor detects tears or breaks in the web and provides an electrical signal to initiate a splice. A vacuum box including a pivotable vacuum bar is provided for creating a high speed butt splice. A method of creating a high speed butt splice using the vacuum box is also presented.

US Patent:

20220387428, Dec 8, 2022

Filed:

Dec 13, 2021

Appl. No.:

17/644045

Inventors:

- Basel, CH
Donovan Noel CHIN - Lexington MA, US
Natalie DALES - Arlington MA, US
Aleem FAZAL - Wilmington MA, US
Timothy Brian HURLEY - Boston MA, US
John KERRIGAN - Wakefield MA, US
Gary O'BRIEN - Maynard MA, US
Lei SHU - Lexington MA, US
Robert SUN - Natick MA, US
Moo Je SUNG - Belmont MA, US

International Classification:

A61K 31/501
A61P 21/00
A61K 31/502
A61K 31/506
A61K 31/5377
A61K 31/551
A61K 45/06
C07D 237/20
C07D 401/04
C07D 401/12
C07D 401/14
C07D 403/10
C07D 403/12
C07D 403/14
C07D 405/14
C07D 409/14
C07D 413/14
C07D 417/14
C07D 471/04
C07D 471/08
C07D 471/10
C07D 487/04
C07D 487/10
A61K 31/41
A61K 31/427
C07D 237/06

Abstract:

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

US Patent:

20200345732, Nov 5, 2020

Filed:

Jul 21, 2020

Appl. No.:

16/934787

Inventors:

- Basel, CH
Donovan Noel CHIN - Lexington MA, US
Natalie DALES - Arlington MA, US
Aleem FAZAL - Burlington MA, US
Timothy Brian HURLEY - Boston MA, US
John KERRIGAN - Wakefield MA, US
Gary O'BRIEN - Maynard MA, US
Lei SHU - Lexington MA, US
Robert SUN - Natick MA, US
Moo Je SUNG - Belmont MA, US

International Classification:

A61K 31/501
A61K 31/502
A61K 31/506
A61K 31/5377
A61K 31/551
A61K 45/06
C07D 237/20
C07D 401/04
C07D 401/12
C07D 401/14
C07D 403/10
C07D 403/12
C07D 403/14
C07D 405/14
C07D 409/14
C07D 413/14
C07D 417/14
C07D 471/04
C07D 471/08
C07D 471/10
C07D 487/04
C07D 487/10
A61K 31/41
A61K 31/427
C07D 237/06

Abstract:

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

US Patent:

20190358226, Nov 28, 2019

Filed:

Jan 2, 2019

Appl. No.:

16/237907

Inventors:

- Basel, CH
Donovan Noel CHIN - Lexington MA, US
Natalie DALES - Arlington MA, US
Aleem FAZAL - Burlington MA, US
Timothy Brian HURLEY - Boston MA, US
John KERRIGAN - Wakefield MA, US
Gary O'BRIEN - Maynard MA, US
Lei SHU - Woburn MA, US
Robert SUN - Natick MA, US
Moo Je SUNG - Belmont MA, US

International Classification:

A61K 31/501
A61K 31/427
C07D 487/10
A61K 31/502
A61K 31/506
A61K 31/5377
A61K 31/551
C07D 237/06
C07D 487/04
A61K 45/06
C07D 237/20
C07D 401/04
C07D 401/12
C07D 401/14
C07D 403/10
C07D 403/12
C07D 403/14
C07D 405/14
C07D 409/14
C07D 413/14
C07D 417/14
C07D 471/04
C07D 471/08
C07D 471/10
A61K 31/41

Abstract:

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.