Gary W O'Brien

US Patent:

7735351, Jun 15, 2010

Filed:

Oct 14, 2008

Appl. No.:

12/251100

Inventors:

Stephen Profit - Framingham MA, US
Gary O'Brien - Chandler AZ, US

Assignee:

MEMSIC, Inc. - Andover MA

International Classification:

G01M 13/00

US Classification:

73 1104, 73 1201

Abstract:

A system measures an amount of wear in athletic footwear by measuring the amount of shock transmitted to a user. The measured shock is used to indicate an amount of how much cushioning has been lost by the footwear. The amount of wear is proportional to the loss of cushioning and an increase in transmitted shock to the user.

US Patent:

20140051672, Feb 20, 2014

Filed:

Aug 7, 2013

Appl. No.:

13/960917

Inventors:

Atwood Kim CHEUNG - Arlington MA, US
Donovan Noel CHIN - Lexington MA, US
Natalie DALES - Arlington MA, US
Aleem FAZAL - Burlington MA, US
Timothy Brian HURLEY - Boston MA, US
John KERRIGAN - Wakefield MA, US
Gary O'BRIEN - Maynard MA, US
Lei SHU - Woburn MA, US
Robert SUN - Natick MA, US
Moo Je SUNG - Belmont MA, US

International Classification:

C07D 401/12
A61K 45/06
C07D 409/14
C07D 401/14
A61K 31/502
C07D 413/14
C07D 417/14
A61K 31/5377
C07D 403/12
A61K 31/551
C07D 471/08
C07D 471/10
C07D 471/04
C07D 403/14
C07D 403/10
C07D 487/10
C07D 487/04
C07D 237/20
C07D 401/04
C07D 405/14
A61K 31/506
A61K 31/501

US Classification:

5142102, 544238, 51425203, 51425204, 514249, 514248, 544237, 544114, 5142365, 51425205, 51425202, 514218, 540575, 544230, 51425206

Abstract:

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

US Patent:

56791950, Oct 21, 1997

Filed:

Sep 1, 1995

Appl. No.:

8/522947

Inventors:

John O'Dwyer - Lynn MA
Richard Sangster - Greenville RI
Gary O'Brien - Rockland MA

Assignee:

John O'Dwyer - Lynn MA

International Classification:

B65H 6906

US Classification:

156159

Abstract:

An input festoon is provided in a web supply apparatus for automatically splicing a relatively stiff web of material such a liner board for making corrugated board. The input festoon includes a dancer roll which is movable along a track to allow storage of a ready web as the ready web is pre-accelerated by an accelerator roll to a running speed prior to creation of a splice at a splice head. Tail grab sensors are mounted on the apparatus above the web between the input roll and the splice head adjacent the input roll. The tail grab sensor detects tears or breaks in the web and provides an electrical signal to initiate a splice. A vacuum box including a pivotable vacuum bar is provided for creating a high speed butt splice. A method of creating a high speed butt splice using the vacuum box is also presented.

US Patent:

20220402904, Dec 22, 2022

Filed:

Dec 16, 2020

Appl. No.:

17/124127

Inventors:

- Basel, CH
Jennifer Stroka COBB - Stow MA, US
Natalie DALES - Arlington MA, US
John Ryan KERRIGAN - Wakefield MA, US
Philip LAM - Somerville MA, US
Hasnain Ahmed MALIK - Boston MA, US
Gary O'BRIEN - Maynard MA, US
Andrew W. PATTERSON - Somerville MA, US
Noel Marie-France THOMSEN - Chelmsford MA, US
Pamela TING - Cambridge MA, US

International Classification:

C07D 413/14
C07D 401/14
C07D 471/04
C07D 417/14
A61K 45/06

Abstract:

The present disclosure relates to compounds of formula (I′) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

US Patent:

20220387428, Dec 8, 2022

Filed:

Dec 13, 2021

Appl. No.:

17/644045

Inventors:

- Basel, CH
Donovan Noel CHIN - Lexington MA, US
Natalie DALES - Arlington MA, US
Aleem FAZAL - Wilmington MA, US
Timothy Brian HURLEY - Boston MA, US
John KERRIGAN - Wakefield MA, US
Gary O'BRIEN - Maynard MA, US
Lei SHU - Lexington MA, US
Robert SUN - Natick MA, US
Moo Je SUNG - Belmont MA, US

International Classification:

A61K 31/501
A61P 21/00
A61K 31/502
A61K 31/506
A61K 31/5377
A61K 31/551
A61K 45/06
C07D 237/20
C07D 401/04
C07D 401/12
C07D 401/14
C07D 403/10
C07D 403/12
C07D 403/14
C07D 405/14
C07D 409/14
C07D 413/14
C07D 417/14
C07D 471/04
C07D 471/08
C07D 471/10
C07D 487/04
C07D 487/10
A61K 31/41
A61K 31/427
C07D 237/06

Abstract:

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

US Patent:

20230108325, Apr 6, 2023

Filed:

Mar 14, 2022

Appl. No.:

17/693759

Inventors:

- Basel, CH
Jennifer Stroka Cobb - Stow MA, US
Natalie Alysia Dales - Arlington MA, US
Janetta Dewhurst - Framingham MA, US
Matthew James Hesse - Oakland CA, US
Rama Jain - Danville CA, US
John Ryan Kerrigan - Wakefield MA, US
Hasnain Ahmed Malik - Boston MA, US
James R. Manning - Emeryville CA, US
Gary O'Brien - Maynard MA, US
Andrew W. Patterson - Somerville MA, US
Noel Marie-France Thomsen - Chelmsford MA, US
Pamela YF TING - Somerville MA, US

International Classification:

C07D 403/14
C07D 405/14
C07D 417/14
A61P 7/00

Abstract:

The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

US Patent:

20230019617, Jan 19, 2023

Filed:

Jun 1, 2022

Appl. No.:

17/829933

Inventors:

- Basel, CH
Jennifer Stroka Cobb - Stow MA, US
Janetta Dewhurst - Framingham MA, US
John Ryan Kerrigan - Wakefield MA, US
Gary O'Brien - Maynard MA, US
Noel Marie-France Thomsen - Chelmsford MA, US
Pamela Ting - Somerville MA, US

International Classification:

C07D 401/14
A61K 31/4545
A61K 45/06
C07D 405/14
A61K 31/55

Abstract:

The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

US Patent:

20200345732, Nov 5, 2020

Filed:

Jul 21, 2020

Appl. No.:

16/934787

Inventors:

- Basel, CH
Donovan Noel CHIN - Lexington MA, US
Natalie DALES - Arlington MA, US
Aleem FAZAL - Burlington MA, US
Timothy Brian HURLEY - Boston MA, US
John KERRIGAN - Wakefield MA, US
Gary O'BRIEN - Maynard MA, US
Lei SHU - Lexington MA, US
Robert SUN - Natick MA, US
Moo Je SUNG - Belmont MA, US

International Classification:

A61K 31/501
A61K 31/502
A61K 31/506
A61K 31/5377
A61K 31/551
A61K 45/06
C07D 237/20
C07D 401/04
C07D 401/12
C07D 401/14
C07D 403/10
C07D 403/12
C07D 403/14
C07D 405/14
C07D 409/14
C07D 413/14
C07D 417/14
C07D 471/04
C07D 471/08
C07D 471/10
C07D 487/04
C07D 487/10
A61K 31/41
A61K 31/427
C07D 237/06

Abstract:

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof;a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.