Gary A Piazza

US Patent:

8044048, Oct 25, 2011

Filed:

Jan 4, 2007

Appl. No.:

11/649373

Inventors:

Gary Piazza - Vestavia AL, US
Robert Reynolds - Birmingham AL, US

Assignee:

Southern Research Institute - Birmingham AL

International Classification:

C07C 233/04
C07D 207/08
C07D 233/64
C07D 213/36
C07D 295/10
C07D 241/04
A61K 31/40
A61K 31/4453
A61K 31/44
A61K 31/495
A61K 31/5375
A61K 31/341
A61K 31/4164
A61K 31/16

US Classification:

5142388, 514618, 514428, 51425212, 514319, 514277, 544399, 544161, 546205, 546340, 548571, 564162

Abstract:

Derivatives of sulindac are provided along with pharmaceutical compositions containing them and use for precancerous conditions and treating cancer. Derivatives of sulindac are also suitable for treating chronic inflammatory conditions. A method for preparing the derivatives is also provided.

US Patent:

20110178106, Jul 21, 2011

Filed:

Jul 10, 2009

Appl. No.:

13/002942

Inventors:

Joseph A. Maddry - Birmingham AL, US
Adam Keeton - Birmingham AL, US
Jason Whitt - Birmingham AL, US
Gary Piazza - Birmingham AL, US

Assignee:

SOUTHERN RESEARCH INSTITUTE OFFICE OF COMMERCIALIZ - BIRMINGHAM AL

International Classification:

A61K 31/519
C07D 401/04
C07D 405/04
C07D 487/04
A61K 31/4709
A61K 31/47
C12Q 1/02
A61P 35/00
A61P 29/00
A61P 31/00
A61P 33/00
A61P 31/10

US Classification:

5142591, 546159, 544281, 514313, 435 29

Abstract:

5-Quinolinone and Imidazopyrimidine compounds are provided that are useful for inhibiting the efflux of any therapeutic agent that is a MRP1 substrate. Also provided is a method for screening to identify additional MRP1 inhibitors.

US Patent:

20120309781, Dec 6, 2012

Filed:

Nov 19, 2010

Appl. No.:

13/510810

Inventors:

Gary A. Piazza - Mobile AL, US
Ashraf H. Abadi - Cairo, EG

Assignee:

Southern Research Institute - Birmingham AL

International Classification:

A61K 31/437
A61P 25/28
A61P 15/10
A61P 9/12
C07D 471/04
A61P 35/00

US Classification:

514292, 546 85

Abstract:

Certain 2-halophenyl, 2,4-dihalophenyl (e.g. 2,4-dichlorophenyl), 3,4-dichlorophenyl (e.g. 3,4-dichlorophenyl), 2,6-dichlorophenyl (2,6-dichlorophenyl) and 2,5-diakoxyphenyl (e.g. 2,5-dimethoxyphenyl) derivatives of tetrahydro-β-carbolines are provided, along with their pharmaceutically acceptable salts; prodrugs and solvates, and compositions containing the compounds. The compounds are useful for the prevention and treatment of cancer, and other indications where PDE5 inhibitors have shown benefits including erectile dysfunction, pulmonary hypertension, enhancing cognitive function, cystic fibrosis, or enhancing the activity of conventional chemotherapeutic drugs. Methods for fabricating the compounds are also provided.

US Patent:

43642985, Dec 21, 1982

Filed:

Aug 24, 1981

Appl. No.:

6/295832

Inventors:

Gary L. Piazza - Atlanta GA

International Classification:

G09B 1506

US Classification:

84465

Abstract:

A stringed simulator 10 is provided which is portable, compact and produces low sound levels. The simulator 10 enables a player to practice both right and left hand fingering which closely simulates practice on a corresponding full-size instrument. The simulator includes a non-acoustic body 11 having peripheral dimensions substantially smaller than a corresponding full-size instrument. An elongate neck 12 is carried by the body 11 and is substantially shorter in length than, but the same width, thickness and contour as, the neck of a corresponding full-size instrument. A plurality of frets 16 positioned on the top surface of neck 12 are correspondingly proportional to fret intervals on a full-size instrument.

US Patent:

20160143912, May 26, 2016

Filed:

Jul 11, 2014

Appl. No.:

14/904632

Inventors:

- Mobile AL, US
Gary A. Piazza - Daphne AL, US

Assignee:

University of South Alabama - Mobile AL

International Classification:

A61K 31/519
A61K 31/415
A61K 31/4709
A61K 31/517
G01N 33/574
C12Q 1/68

Abstract:

Disclosed are methods for treating cancer and precancerous conditions with PDE10A specific inhibitors and diagnosis of neoplastic diseases based on elevated levels of PDE10A.

US Patent:

20140171477, Jun 19, 2014

Filed:

Mar 16, 2012

Appl. No.:

14/005462

Inventors:

Gary A. Piazza - Mobile AL, US
Ashraf H. Abadi - Cairo, EG

International Classification:

C07D 231/06

US Classification:

514403, 5483797

Abstract:

Derivatives of celecoxib that lack cyclooxygenase inhibitory activity but have improved PDE5 inhibitory activity are provided along with pharmaceutical compositions containing them for the treatment or prevention of cancer. Such compounds are expected to have reduced toxicity compared with celecoxib and other cyclooxygenase inhibitors, and greater efficacy compared with conventional PDE5 inhibitors. Derivatives of celecoxib are also suitable for treating chronic inflammatory conditions, erectile dysfunction, pulmonary hypertension, congestive heart failure, and enhancement of cognitive function.

US Patent:

20140094492, Apr 3, 2014

Filed:

Mar 30, 2012

Appl. No.:

14/008271

Inventors:

Robert Reynolds - Birmingham AL, US
Bini Mathew - Birmingham AL, US
Gary A. Piazza - Mobile AL, US

Assignee:

Southern Research Institute - Birmingham AL

International Classification:

C07D 307/52
C07D 213/38
C07C 211/19
C07D 295/13

US Classification:

514319, 514332, 514357, 514471, 514648, 546246, 546264, 546333, 549495, 564323

Abstract:

Derivatives of sulindac that lack cyclooxygenase inhibitory activity are provided along with pharmaceutical compositions containing them and use for treatment or prevention of cancer. The derivatives of sulindac are also suitable for treating chronic inflammatory conditions. A method for preparing the derivatives is also provided.