Gaurang A Patel

US Patent:

20180303757, Oct 25, 2018

Filed:

Oct 21, 2016

Appl. No.:

15/770021

Inventors:

- Bridgewater NJ, US
Navnit H. Shah - Clifton NJ, US
Gaurang Patel - Iselin NJ, US
Murali Mohan Bommana - Bridgewater NJ, US
Ashish Chatterji - East Brunswick NJ, US
Anita Kumar - Miller Place NY, US
Petra Inbar - Glen Rock NJ, US
Furong Liu - Basking Ridge NJ, US
Srinivas Kone - Monroe NJ, US
Priti L. Jagani - Hillsborough NJ, US
Wantanee Phuapradit - Montville NJ, US

Assignee:

KASHIV PHARMA LLC - Bridgewater NJ

International Classification:

A61K 9/20
A61K 31/485

Abstract:

The present technology relates to an extended-release solid oral pharmaceutical composition, comprising a cured blend of a melt-extruded first component and a second component, wherein the melt-extruded first component comprises a therapeutically effective amount of an opioid or a pharmaceutically acceptable salt thereof, at least one PEO polymer, and a stabilizing agent; and the second component comprises at least one PEO polymer and an oxidative stabilizing agent. The extended-release pharmaceutical compositions of the present technology provide crush-resistant and abuse-deterrent formulations featuring enhanced heat stability, resistance to drug segregation, and resistance to alcohol-induced dose dumping.