Geoffrey C Gurtner

US Patent:

8063263, Nov 22, 2011

Filed:

Jan 22, 2009

Appl. No.:

12/358159

Inventors:

Geoffrey C. Gurtner - Palo Alto CA, US
Reinhold H. Dauskardt - Menlo Park CA, US
Michael T. Longaker - Atherton CA, US
Paul Yock - Atherton CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61F 13/00
A61B 17/00
A61B 17/08
C08L 15/00

US Classification:

602 41, 602 42, 602 43, 602 50, 602 53, 602 54, 606201, 606216, 523111

Abstract:

Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

US Patent:

8115048, Feb 14, 2012

Filed:

Jan 22, 2009

Appl. No.:

12/358164

Inventors:

Geoffrey C. Gurtner - Palo Alto CA, US
Reinhold H. Dauskardt - Menlo Park CA, US
Michael T. Longaker - Atherton CA, US
Paul Yock - Atherton CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61F 13/00
A61B 17/00
A61B 17/08
C08L 15/00

US Classification:

602 50, 602 42, 602 43, 602 53, 602 54, 606201, 606216, 523111

Abstract:

Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

US Patent:

8168850, May 1, 2012

Filed:

Jan 22, 2009

Appl. No.:

12/358162

Inventors:

Geoffrey C. Gurtner - Palo Alto CA, US
Reinhold H. Dauskardt - Menlo Park CA, US
Michael T. Longaker - Atherton CA, US
Paul Yock - Atherton CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61F 13/00
A61B 17/00
A61B 17/08
C08L 15/00

US Classification:

602 50, 602 42, 602 43, 602 53, 602 54, 606201, 606216, 523111

Abstract:

Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

US Patent:

8183428, May 22, 2012

Filed:

Jan 22, 2009

Appl. No.:

12/358164

Inventors:

Geoffrey C. Gurtner - Palo Alto CA, US
Reinhold H. Dauskardt - Menlo Park CA, US
Michael T. Longaker - Atherton CA, US
Paul Yock - Atherton CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61F 13/00
A61B 17/00
A61B 17/08
C08L 15/00

US Classification:

602 50, 602 42, 602 43, 602 53, 602 54, 606201, 606216, 523111

Abstract:

Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

US Patent:

8197499, Jun 12, 2012

Filed:

Dec 19, 2008

Appl. No.:

12/340588

Inventors:

Geoffrey C. Gurtner - Stanford CA, US
Gerald G. Fuller - Stanford CA, US
Michael T. Longaker - Atherton CA, US
Jayakumar Rajadas - Cupertino CA, US
Gordon Saul - Palo Alto CA, US
C. Travis Rappleye - San Jose CA, US
Evgenia Mandrusov - Santa Clara CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Stanford CA

International Classification:

A61B 17/08

US Classification:

606153, 606154

Abstract:

Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.

US Patent:

8216259, Jul 10, 2012

Filed:

Jun 21, 2007

Appl. No.:

11/766779

Inventors:

Geoffrey C. Gurtner - Stanford CA, US
Gerald G. Fuller - Stanford CA, US
Michael T. Longaker - Atherton CA, US
Jayakumar Rajadas - Stanford CA, US

Assignee:

The Board of Trustees of the Leland Stanford Jr. University - Palo Alto CA

International Classification:

A61B 17/08

US Classification:

606153, 606154

Abstract:

Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient's body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.

US Patent:

8389791, Mar 5, 2013

Filed:

Apr 18, 2011

Appl. No.:

13/089104

Inventors:

Geoffrey C. Gurtner - Palo Alto CA, US
Reinhold H. Dauskardt - Menlo Park CA, US
Michael T. Longaker - Atherton CA, US
Paul Yock - Atherton CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

A61F 13/00
A61B 17/00
A61B 17/08
C08L 15/00

US Classification:

602 41, 602 42, 602 43, 602 53, 602 54, 606201, 606216, 523111

Abstract:

Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combination of stress and strain. The control of a wound's mechanical environment can be active, passive, dynamic, or static. The devices are configured to be removably secured to a skin surface in proximity to the wound site and shield the wound from endogenous and/or exogenous stress.

US Patent:

8586305, Nov 19, 2013

Filed:

Dec 16, 2010

Appl. No.:

13/516195

Inventors:

Geoffrey Gurtner - Stanford CA, US
Michael Januszyk - Menlo Park CA, US
Ivan Vial - Stanford CA, US
Jason Glotzbach - Palo Alto CA, US

Assignee:

The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA

International Classification:

C12Q 1/68

US Classification:

435 61, 435378, 536 2431

Abstract:

Understanding the heterogeneity within a stem cell population remains a major impediment to the development of clinically effective cell-based therapies. Gene expression patterns exhibited by individual cells are a crucial component of this heterogeneity, yet transcriptional events within a single cell are inherently stochastic and can produce tremendous variability, even among genetically identical cells. It remains unclear how mammalian cellular systems overcome this intrinsic noisiness of gene expression to produce consequential variations in function. To address these questions, we utilized a novel single cell analysis method to characterize transcriptional programs across hundreds of individual murine long-term hematopoietic stem cells (LT-SCs). We demonstrate that multiple subpopulations exist within this putatively homogeneous stem cell population, defined by nonrandom patterns that are distinguishable from noise and can predict functional properties of these cells. This represents a powerful new tool to elucidate the relationship between transcriptional and phenotypic variation within a cell population.