George H. Denny - Lansdale PA Walfred S. Saari - Lansdale PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D20914
US Classification:
26032615
Abstract:
Substituted trichloroacetamidine derivatives are prepared by reacting trichloroacetamidine with an appropriately substituted compound also substituted with a suitable leaving group. The leaving groups are halogen, quaternary or tertiary amines, methanesulfonate, toluenesulfonate, and the like.
Process For The Preparation Of Substituted Trichloroacetamidine Derivatives
Substituted trichloroacetamidine derivatives are prepared by treating an appropriately substituted imidate with ammonia. The imidate intermediates are prepared by treating an appropriately substituted amine with an imidating reagent.
Process For The Preparation Of Substituted Trichloroacetamidine Derivatives
Substituted trichloroacetamidine derivatives are prepared by reacting an appropriately substituted amine with trichloroacetamidine or a trichloroacetimidate. The substituted amines are 3-aminomethyl indole and 2-acetoxy-3-phenoxy propylamine.
George Denny (1949-1953), Bill Wolf (1960-1964), Janis Lindsay (1981-1985), Sue Rombach Rombach (1944-1948), Cathie Birch (1957-1961), Paula Bernard (1970-1974)