George W Doherty

US Patent:

6420418, Jul 16, 2002

Filed:

Aug 14, 2000

Appl. No.:

09/638074

Inventors:

William K. Hagmann - Westfield NJ
Stephen E. Delaszlo - Rumson NJ
George Doherty - Princeton NJ
Linda L. Chang - Wayne NJ
Ginger X. Yang - Jersey City NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 3134

US Classification:

514471, 514470, 514465, 549322, 549484

Abstract:

Compounds of Formula I are antagonists of VLA-4 and/or 47, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of AIDS-related dementia, allergic conjunctivitis, allergic rhinitis, Alzheimers disease, asthma, atherosclerosis, autologous bone marrow transplantation, certain types of toxic and immune-based nephritis, contact dermal hypersensitivity, inflammatory bowel disease including ulcerative colitis and Crohns disease, inflammatory lung diseases, inflammatory sequelae of viral infections, meningitis, multiple sclerosis, multiple myeloma, myocarditis, organ transplantation, psoriasis, pulmonary fibrosis, restenosis, retinitis, rheumatoid arthritis, septic arthritis, stroke, tumor metastasis, uveititis, and type I diabetes.

US Patent:

6482840, Nov 19, 2002

Filed:

May 21, 2001

Appl. No.:

09/862194

Inventors:

William K. Hagmann - Westfield NJ
George A. Doherty - Princeton NJ
Shrenik Shah - Metuchen NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

A61K 3144

US Classification:

514352, 546312

Abstract:

Compounds of Formula I are antagonists of VLA-4 and/or , and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of AIDS-related dementia, allergic conjunctivitis, allergic rhinitis, Alzheimers disease, asthma, atherosclerosis, autologous bone marrow transplantation, certain types of toxic and immune-based nephritis, contact dermal hypersensitivity, inflammatory bowel disease including ulcerative colitis and Crohns disease, inflammatory lung diseases, inflammatory sequelae of viral infections, meningitis, multiple sclerosis, multiple myeloma, myocarditis, organ transplantation, psoriasis, pulmonary fibrosis, restenosis, retinitis, rheumatoid arthritis, septic arthritis, stroke, tumor metastasis, uveititis, and type I diabetes.

US Patent:

6855708, Feb 15, 2005

Filed:

Mar 13, 2002

Appl. No.:

10/096607

Inventors:

Linus S. Lin - Westfield NJ, US
George Doherty - Princeton NJ, US
Shrenik K. Shah - Metuchen NJ, US
Linda L. Chang - Wayne NJ, US
William K. Hagmann - Westfield NJ, US
Richard A. Mumford - Red Bank NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K031/55
A61K031/47

US Classification:

51421701, 514241, 514309, 514406, 540593, 546120, 546141

Abstract:

Compounds of Formula I are antagonists of VLA-4 and/or alpha4/beta7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of AIDS-related dementia, allergic conjunctivitis, allergic rhinitis, Alzheimer's disease, asthma, atherosclerosis, autologous bone marrow transplantation, certain types of toxic and immune-based nephritis, contact dermal hypersensitivity, inflammatory bowel disease including ulcerative colitis and Crohn's disease, inflammatory lung diseases, inflammatory sequelae of viral infections, meningitis, multiple sclerosis, multiple myeloma, myocarditis, organ transplantation, psoriasis, pulmonary fibrosis, restenosis, retinitis, rheumatoid arthritis, septic arthritis, stroke, tumor metastasis, uveititis, and type I diabetes.

US Patent:

7605171, Oct 20, 2009

Filed:

Dec 13, 2004

Appl. No.:

10/575790

Inventors:

Vincent J. Colandrea - North Brunswick NJ, US
George A. Doherty - Superior CO, US
Jeffrey J. Hale - Westfield NJ, US
Pei Huo - Millburn NJ, US
Irene E. Legiec - Mountainside NJ, US
Leslie Toth - Woodbridge NJ, US
Petr Vachal - Summit NJ, US
Lin Yan - East Brunswick NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31/443
A61K 31/4245
C07D 413/04
C07D 271/06

US Classification:

514340, 514364, 5462694, 548131

Abstract:

The present invention encompasses compounds of Formula I:.

US Patent:

20060252741, Nov 9, 2006

Filed:

May 12, 2004

Appl. No.:

10/554665

Inventors:

Vincent Colandrea - North Brunswick NJ, US
George Doherty - Superior CO, US
Jeffrey Hale - Westfield NJ, US
Christopher Lynch - Trevor WI, US
Sander Mills - Scotch Plains NJ, US
William Neway III - Newtown PA, US
Leslie Toth - Woodbridge NJ, US

International Classification:

A61K 31/4439
C07D 413/04
C07D 413/14

US Classification:

514210200, 514341000, 546269400

Abstract:

p-00010000