George F Greene

US Patent:

20010001835, May 24, 2001

Filed:

Dec 5, 2000

Appl. No.:

09/730071

Inventors:

George Greene - Costa Mesa CA, US
Robert Rosenbluth - Laguna Niguel CA, US
Brian Cox - Laguna Niguel CA, US

International Classification:

A61F002/06

US Classification:

623/001230, 623/001490

Abstract:

A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.

US Patent:

20020120276, Aug 29, 2002

Filed:

May 29, 2001

Appl. No.:

09/867340

Inventors:

George Greene - Costa Mesa CA, US
Gregory Cruise - Rancho Santa Margarita CA, US
Michael Constant - Mission Viejo CA, US
Brian Cox - Laguna Niguel CA, US

Assignee:

MicroVention, Inc.

International Classification:

A61F002/06

US Classification:

606/108000

Abstract:

An embolization device includes one or more expansible, hydrophilic embolizing elements non-releasably carried along the length of a filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In a second embodiment, an elongate, continuous, coaxial embolizing element is non-releasably i- fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip. In either of the embodiments, the embolizing elements may be made of a hydrophilic, macroporous, polymeric, hydrogel foam material. In the second embodiment, the elongate embolizing element is preferably made of a porous, environmentally-sensitive, expansile hydrogel that expands, after a predetermined time delay, in response to a change in an environmental parameter, such as pH or temperature.

US Patent:

20020177855, Nov 28, 2002

Filed:

May 29, 2002

Appl. No.:

10/157621

Inventors:

George Greene - Costa Mesa CA, US
Gregory Cruise - Rancho Santa Margarita CA, US
Michael Constant - Mission Viejo CA, US
Brian Cox - Laguna Niguel CA, US
Terrance Tran - Westminster CA, US

International Classification:

A61F011/00

US Classification:

606/108000

Abstract:

An embolization device for occluding a body cavity includes one or more elongated, expansible, hydrophilic embolizing elements non-releasably carried along the length of an elongated filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In second, third and fourth embodiments, an elongate, continuous, coaxial embolizing element is non-releasably fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip, and optionally includes a lumenal reservoir for delivery of therapeutic agents. Exemplary methods for making these devices include skewering and molding the embolizing elements. In any of the embodiments, the embolizing elements may be made of a hydrophilic, macro-porous, polymeric, hydrogel foam material. In the second, third and fourth embodiments, the elongate embolizing element is preferably made of a porous, environmentally-sensitive, expansile hydrogel, which can optionally be made biodegradable and/or bioresorbable, having a rate of expansion that changes in response to a change in an environmental parameter, such as the pH or temperature of the environment.

US Patent:

20020188311, Dec 12, 2002

Filed:

May 10, 2002

Appl. No.:

10/143724

Inventors:

David Ferrera - Manhattan Beach CA, US
George Greene - Costa Mesa CA, US
Brian Cox - Laguna Niguel CA, US
Robert Rosenbluth - Laguna Niguel CA, US

International Classification:

A61M029/00

US Classification:

606/191000

Abstract:

A mechanism for the deployment of a filamentous endovascular device includes a flexible deployment tube having an open proximal end, and a coupling element attached to the proximal end of the endovascular device. The deployment tube includes a distal section terminating in an open distal end, with a lumen defined between the proximal and distal ends. A retention sleeve is fixed around the distal section and includes a distal extension extending a short distance past the distal end of the deployment tube. The endovascular device is attached to the distal end of the deployment tube by fixing the retention sleeve around the coupling element, so that the coupling element is releasably held within the distal extension of the deployment tube. In use, the deployment tube, with the implant attached to its distal end, is passed intravascularly through a microcatheter to a target vascular site until the endovascular device is located within the site. To detach the endovascular device from the deployment tube, a liquid is injected through the lumen of the deployment tube so as to apply pressure to the upstream side of the coupling element, which is thus pushed out of the retention sleeve by the fluid pressure. The coupling element may include an internal or peripheral purge passage that allows air to be purged from the microcatheter prior to the intravascular passage of the endovascular device.

US Patent:

20030083737, May 1, 2003

Filed:

Dec 4, 2002

Appl. No.:

10/309442

Inventors:

George Greene - Costa Mesa CA, US
Robert Rosenbluth - Laguna Niguel CA, US
Brian Cox - Laguna Niguel CA, US

International Classification:

A61F002/06

US Classification:

623/001230, 623/001490, 623/901000

Abstract:

A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.

US Patent:

20030088311, May 8, 2003

Filed:

Dec 16, 2002

Appl. No.:

10/320033

Inventors:

George Greene - Costa Mesa CA, US
Robert Rosenbluth - Laguna Nigel CA, US
Brian Cox - Laguna Nigel CA, US

International Classification:

A61F002/06

US Classification:

623/001230, 623/001490

Abstract:

A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.

US Patent:

20040059370, Mar 25, 2004

Filed:

Sep 24, 2003

Appl. No.:

10/670142

Inventors:

George Greene - Costa Mesa CA, US
Gregory Cruise - Rancho Santa Margarita CA, US
Michael Constant - Mission Viejo CA, US
Brian Cox - Laguna Niguel CA, US
Terrance Tran - Westminster CA, US

International Classification:

A61M029/00

US Classification:

606/195000

Abstract:

An embolization device for occluding a body cavity includes one or more elongated, expansible, hydrophilic embolizing elements non-releasably carried along the length of an elongated filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In second, third and fourth embodiments, an elongate, continuous, coaxial embolizing element is non-releasably fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip, and optionally includes a lumenal reservoir for delivery of therapeutic agents. Exemplary methods for making these devices include skewering and molding the embolizing elements. In any of the embodiments, the embolizing elements may be made of a hydrophilic, macroporous, polymeric, hydrogel foam material. In the second, third and fourth embodiments, the elongate embolizing element is preferably made of a porous, environmentally-sensitive, expansile hydrogel, which can optionally be made biodegradable and/or bioresorbable, having a rate of expansion that changes in response to a change in an environmental parameter, such as the pH or temperature of the environment.

US Patent:

20060149299, Jul 6, 2006

Filed:

Feb 8, 2006

Appl. No.:

11/350357

Inventors:

George Greene - Costa Mesa CA, US
Gregory Cruise - Rancho Santa Margarita CA, US
Michael Constant - Mission Viejo CA, US
Brian Cox - Laguna Niguel CA, US
Terrance Tran - Westminster CA, US

Assignee:

MICROVENTION, INC. - Aliso Viejo CA

International Classification:

A61B 17/08

US Classification:

606158000

Abstract:

An embolization device for occluding a body cavity includes one or more elongated, expansible, hydrophilic embolizing elements non-releasably carried along the length of an elongated filamentous carrier that is preferably made of a very thin, highly flexible filament or microcoil of nickel/titanium alloy. At least one expansile embolizing element is non-releasably attached to the carrier. A first embodiment includes a plurality of embolizing elements fixed to the carrier at spaced-apart intervals along its length. In second, third and fourth embodiments, an elongate, continuous, coaxial embolizing element is non-releasably fixed to the exterior surface of the carrier, extending along a substantial portion of the length of the carrier proximally from a distal tip, and optionally includes a lumenal reservoir for delivery of therapeutic agents. Exemplary methods for making these devices include skewering and molding the embolizing elements. In any of the embodiments, the embolizing elements may be made of a hydrophilic, macroporous, polymeric, hydrogel foam material. In the second, third and fourth embodiments, the elongate embolizing element is preferably made of a porous, environmentally-sensitive, expansile hydrogel, which can optionally be made biodegradable and/or bioresorbable, having a rate of expansion that changes in response to a change in an environmental parameter, such as the pH or temperature of the environment.

Address:

10941 Granada Rd, North Chesterfield, VA 23235

VIN:

1FAFP53U17A134141

Make:

FORD

Model:

TAURUS

Year:

2007