George T Grosu from 117 Prospect Pl, Chestnut Ridge, NY 10965, age 82, Phone: (845)7354966

Resumes

George T Grosu

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Location:

117 Prospect Pl, Pearl River, NY 10965

Industry:

Pharmaceuticals

Languages:

English

Software Developer At Continental Automotive Romania Srl

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Position:

Software Developer at Continental Automotive Romania SRL

Location:

Iasi County, Romania

Industry:

Automotive

Work:

Continental Automotive Romania SRL since Aug 2009
Software Developer
Continental Jun 2006 - Aug 2009
Student

Education:

Universitatea Tehnică „Gh. Asachi” din Iași 2009 - 2012

Us Patents

Alkynyl Containing Hydroxamic Acid Compounds As Matrix Metalloproteinase And Tace Inhibitors
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US Patent:

6340691, Jan 22, 2002
Filed:

Jan 27, 2000
Appl. No.:

09/492977
Inventors:

Jeremy I. Levin - New City NY
Aranapakam M. Venkatesan - Rego Park NY
Derek C. Cole - New City NY
James M. Chen - Bedminister NJ
Jamie M. Davis - Nyack NY
George T. Grosu - Pearl River NY
Assignee:

American Cyanamid Company - Madison NJ
International Classification:

C07D21140
US Classification:

514307, 514327, 514349, 514311, 514454, 514443, 514416, 514423, 514613, 514617, 514618, 514619, 514621, 546216, 546297, 546170, 546143, 546147, 548471, 548472, 548535, 549 57, 549 58, 549388, 564162, 564163, 564167, 564169, 564171
Abstract:

Compounds of the formula are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohns disease and degenerative cartilage loss.

N-Hydroxy-2-(Alkyl,Aryl Or Heteroaryl Sulfanyl, Sulfinyl Or Sulfonyl) 3-Substituted Alkyl, Aryl Or Heteroarylamides As Matrix Metalloproteinase Inhibitors
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US Patent:

6342508, Jan 29, 2002
Filed:

Aug 17, 2000
Appl. No.:

09/640532
Inventors:

Aranapakam Mudumbai Venkatesan - Rego Park NY
George Theodore Grosu - Pearl River NY
Jamie Marie Davis - Nyack NY
Derek Cecil Cole - New City NY
Assignee:

American Cyanamid Company - Madison NH
International Classification:

A61K 31165
US Classification:

514311, 514357, 514400, 514417, 514575, 546172, 546233, 5483381, 548477, 562621, 562623
Abstract:

Matrix metalloproteinases (MMps) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF- converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF- from membrane bound TNF- precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF- converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection. The compounds of this invention are represented by the formula where R , R , R and R are described herein.

N-Hydroxy-2-(Alkyl, Aryl, Or Heteroaryl Sulfanyl, Sulfinyl Or Sulfonyl)-3-Substituted Alkyl, Aryl Or Heteroarylamides As Matrix Metalloproteinase Inhibitors
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US Patent:

6462073, Oct 8, 2002
Filed:

Jul 5, 2001
Appl. No.:

09/899641
Inventors:

Aranapakam Mudumbai Venkatesan - Rego Park NY
George Theodore Grosu - Pearl River NY
Jamie Marie Davis - Nyack NY
Jannie Lea Baker - White Plains NY
Jeremy Ian Levin - New City NY
Assignee:

American Home Products Corporation - Madison NJ
International Classification:

A61K 3140
US Classification:

514423, 548537, 548517, 540596, 540604, 514212, 514422
Abstract:

Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF- from membrane bound TNF- precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (is) and TNF- converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having the formula wherein R and R form a heterocyclic ring and A is S, S(O), or S(O)2, and R and R are defined herein.

Alkynyl Containing Hydroxamic Acid Compounds As Matrix Metalloproteinase And Tace Inhibitors
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US Patent:

6825354, Nov 30, 2004
Filed:

Nov 13, 2001
Appl. No.:

10/055502
Inventors:

Jeremy I. Levin - New City NY
Aranapakam M. Venkatesan - Rego Park NY
Derek C. Cole - New City NY
James M. Chen - Stoddard Court NJ
Jamie M. Davis - Nyack NY
George T. Grosu - Pearl River NY
Assignee:

Wyeth Holdings Corporation - Madison NJ
International Classification:

C07D21172
US Classification:

546290, 514345, 514352, 514353
Abstract:

Compounds of the formula are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohns disease and degenerative cartilage loss.

Benzofuranyl-And Benzothienyl-Piperazinyl Quinolines And Methods Of Their Use
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US Patent:

7276603, Oct 2, 2007
Filed:

Apr 29, 2004
Appl. No.:

10/835185
Inventors:

Aranapakam Mudumbai Venkatesan - Regopark NY, US
Osvaldo Dos Santos - Kew Garden NY, US
Magda Asselin - Mahwah NJ, US
George Theodore Grosu - Pearl River NY, US
Deborah A. Evrard - Hamilton Square NJ, US
Richard Eric Mewshaw - King of Prussia PA, US
Kristin Meagher - Novi MI, US
Assignee:

Wyeth - Madison NJ
International Classification:

C07D 405/12
C07D 409/12
A61K 31/496
US Classification:

544363, 51425306
Abstract:

Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed. Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives of Formula I are disclosed:.

Piperazine-Piperidine Antagonists And Agonists Of The 5-Ht Receptor
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US Patent:

7671056, Mar 2, 2010
Filed:

Jun 9, 2006
Appl. No.:

11/450942
Inventors:

Magda Asselin - Mahwah NJ, US
George Theodore Grosu - Pearl River NY, US
Annmarie Louise Sabb - Pennington NJ, US
Wayne Everett Childers - New Hope PA, US
Lisa Marie Havran - Florence NJ, US
Zhongqi Shen - Plainsboro NJ, US
James Jacob Bicksler - Titusville NJ, US
Dan Chaekoo Chong - Plainsboro NJ, US
Assignee:

Wyeth LLC - Madison NJ
International Classification:

A61K 31/496
C07D 401/14
C07D 405/14
C07D 409/14
C07D 413/14
US Classification:

51425306, 51425307, 51425308, 51425309, 5142531, 51425311, 544363, 544360, 544364
Abstract:

The present invention relates to novel piperazine-piperidine compounds. The compounds are useful as 5-HT1A binding agents, particularly as 5-HT1A receptor antagonists and agonists. These compounds are useful in treating central nervous system disorders, such as cognition disorders, anxiety disorders, depression and sexual dysfunction. The invention relates to compounds and pharmaceutically acceptable salts of formula (I′):.

Benzofuranyl- And Benzothienyl- Piperazinyl Quinolines And Methods Of Their Use
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US Patent:

20090054454, Feb 26, 2009
Filed:

Aug 21, 2007
Appl. No.:

11/842393
Inventors:

Aranapakam Mudumbai Venkatesan - Regopark NY, US
Osvaldo Dos Santos - Kew Garden NY, US
Magda Asselin - Mahwah NJ, US
George Theodore Grosu - Pearl River NY, US
Deborah A. Evrard - Hamilton Square NJ, US
Richard Eric Mewshaw - King of Prussia PA, US
Kristin Meagher - Novi MI, US
International Classification:

A61K 31/496
A61P 25/18
A61P 25/22
A61P 25/24
A61P 25/34
A61P 35/00
C07D 295/00
US Classification:

51425306, 544363
Abstract:

Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.

3-Substituted-1H-Pyrrolo[2,3-B]Pyridine And 3-Substituted-1H-Pyrrolo[3,2-B]Pyridine Compounds, Their Use As Mtor Kinase And Pi3 Kinase Inhibitors, And Their Syntheses
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US Patent:

20090298820, Dec 3, 2009
Filed:

May 28, 2009
Appl. No.:

12/473658
Inventors:

Gary Harold Birnberg - Tuxedo Park NY, US
Gloria Jean MacEwan - Monroe NY, US
Matthew Gregory Bursavich - Salt Lake City UT, US
Sabrina Lombardi - New Haven CT, US
Nan Zhang - Bayside NY, US
Adam Matthew Gilbert - Congers NY, US
George Theordore Grosu - Pearl River NY, US
Natasja Brooijmans - New York NY, US
Thai Hiep Nguyen - Fair Lawn NJ, US
Assignee:

Wyeth - Madison NJ
International Classification:

A61K 31/437
A61K 31/5375
A61K 31/5377
A61K 31/496
C07D 471/04
A61P 35/00
C07D 498/08
A61P 29/00
A61P 17/00
A61P 19/00
US Classification:

5142305, 5142345, 51425304, 514300, 544105, 544127, 544362, 546113
Abstract:

The invention relates to 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula 1: