Gerald Patrick Donovan

US Patent:

8114965, Feb 14, 2012

Filed:

Nov 7, 2007

Appl. No.:

11/983372

Inventors:

Paul J. Maddon - Scarsdale NY, US
Gerald P. Donovan - New York NY, US
William C. Olson - Ossining NY, US
Norbert Schuelke - Dedham MA, US
Jason Gardner - Merseyside, GB
Dangshe Ma - Milwood NY, US
Jaspal S. Kang - Surrey, CA
Larry Green - San Francisco CA, US

Assignee:

PSMA Development Company, LLC - Tarrytown NY
Amgen Fremont Inc. - Fremont CA

International Classification:

C07K 16/18

US Classification:

5303871, 5303917, 5303873, 5303877, 5303888, 5303913, 536 235, 4353201, 435325, 435 691, 435328, 435330

Abstract:

The invention includes antibodies or antigen-binding fragments thereof which bind specifically to conformational epitopes on the extracellular domain of PSMA, compositions containing one or a combination of such antibodies or antigen-binding fragments thereof, hybridoma cell lines that produce the antibodies, and methods of using the antibodies or antigen-binding fragments thereof for cancer diagnosis and treatment. The invention also includes oligomeric forms of PSMA proteins, compositions comprising the multimers, and antibodies that selectively bind to the multimers.

US Patent:

8470330, Jun 25, 2013

Filed:

Jul 28, 2010

Appl. No.:

12/845686

Inventors:

Paul J. Maddon - Scarsdale NY, US
Gerald P. Donovan - Kittery ME, US
William C. Olson - Yorktown Heights NY, US
Norbert Schuelke - East Walpole MA, US
Jason Gardner - Wayne PA, US
Dangshe Ma - Millwood NY, US
Jaspal S. Kang - Surrey, CA
Larry Green - San Francisco CA, US

Assignee:

PSMA Development Company, LLC - Tarrytown NY
Amgen Fremont Inc. - Thousand Oaks CA

International Classification:

A61K 39/00
A61K 39/395

US Classification:

4241831, 4241301, 4241331, 4241381, 4241551, 4241741, 4241781, 4241811, 530350, 5303871, 5303873, 5303877, 5303888, 5303913, 5303917

Abstract:

The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.

US Patent:

20040033229, Feb 19, 2004

Filed:

Mar 21, 2003

Appl. No.:

10/395894

Inventors:

Paul Maddon - Scarsdale NY, US
Gerald Donovan - New York NY, US
William Olson - Ossining NY, US
Norbert Schulke - New City NY, US
Jason Gardner - Ardsley NY, US
Dangshe Ma - Millwood NY, US

International Classification:

G01N033/574
A61K039/395
C07K016/30

US Classification:

424/155100, 435/007230, 530/388800

Abstract:

The invention includes antibodies or antigen-binding fragments thereof which bind specifically to conformational epitopes on the extracellular domain of PSMA, compositions containing one or a combination of such antibodies or antigen-binding fragments thereof, hybridoma cell lines that produce the antibodies, and methods of using the antibodies or antigen-binding fragments thereof for cancer diagnosis and treatment. The invention also includes oligomeric forms of PSMA proteins, compositions comprising the multimers, and antibodies that selectively bind to the multimers.

US Patent:

20040161776, Aug 19, 2004

Filed:

Oct 27, 2003

Appl. No.:

10/695667

Inventors:

Paul Maddon - Scarsdale NY, US
Gerald Donovan - New York NY, US
William Olson - Ossining NY, US
Norbert Schulke - New City NY, US
Jason Gardner - Ardsley NY, US
Dangshe Ma - Millwood NY, US

International Classification:

C12Q001/68
G01N033/574
C07H021/04
C07K014/705

US Classification:

435/006000, 435/007230, 435/069100, 435/320100, 435/325000, 530/350000, 536/023500

Abstract:

The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune reponse to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.

US Patent:

20130202618, Aug 8, 2013

Filed:

Apr 15, 2011

Appl. No.:

13/641315

Inventors:

Dangshe Ma - Millwood NY, US
Kirsten Nagashima - Valhalla NY, US
Brian Kennedy - Yorktown Heights NY, US
Gerald P. Donovan - Kittery ME, US
Yun Kang - Livingstone NJ, US
William C. Olson - Yorktown Heights NY, US
Shankar Kumar - Pleasanton CA, US
Naoya Tsurushita - Palo Alto CA, US
Andre J. Marozsan - Port Chester NY, US
Albert Cupo - Stamford CT, US

Assignee:

Progenics Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

C07K 16/12
A61K 45/06
A61K 39/40

US Classification:

4241671, 5303895, 5303884, 5303873, 435340

Abstract:

Provided herein are reagents, compositions, and therapies with which to treat infection and related disease conditions and pathologies, such as -associated diarrhea, resulting from infection by bacteria and the enterotoxins produced by these bacteria. In particular, antibodies or antigen-binding fragments thereof that bind specifically to toxin A and/or toxin B of and neutralize the activities of these toxins; compositions comprising such antibodies; and methods of using the antibodies and the compositions are provided.

US Patent:

20150197577, Jul 16, 2015

Filed:

Sep 10, 2012

Appl. No.:

13/608337

Inventors:

Paul J. Maddon - Scarsdale NY, US
Gerald P. Donovan - Kittery ME, US
William C. Olson - Yorktown Heights NY, US
Norbert Schuelke - East Walpole MA, US
Jason Gardner - Wayne PA, US
Dangshe Ma - Millwood NY, US
Jaspal S. Kang - Surrey, CA
Larry Green - San Francisco CA, US

Assignee:

PSMA Development Company, LLC - Tarrytown NY
Amgen Fremont Inc. - Thousand Oaks CA

International Classification:

C07K 16/40
A61K 51/10
G01N 33/574

Abstract:

The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.

US Patent:

20150175681, Jun 25, 2015

Filed:

Mar 9, 2015

Appl. No.:

14/642342

Inventors:

- Tarrytown NY, US
Kirsten Nagashima - Valhalla NY, US
Brian Kennedy - Yorktown Heights NY, US
Gerald P. Donovan - Kittery ME, US
Yun Kang - Livingstone NJ, US
William C. Olson - Yorktown Heights NY, US
Shankar Kumar - Pleasanton CA, US
Naoya Tsurushita - Palo Alto CA, US
Andre J. Marozsan - Port Chester NY, US
Albert Cupo - Stamford CT, US

International Classification:

C07K 16/12
A61K 39/40

Abstract:

Provided herein are reagents, compositions, and therapies with which to treat infection and related disease conditions and pathologies, such as -associated diarrhea, resulting from infection by bacteria and the enterotoxins produced by these bacteria. In particular, antibodies or antigen-binding fragments thereof that bind specifically to toxin A and/or toxin B of and neutralize the activities of these toxins; compositions comprising such antibodies; and methods of using the antibodies and the compositions are provided.