Gerald H Kaplan from Monroe Twp, NJ, age 83

4-Pyridinyl-N-Acyl-L-Phenylalanines
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US Patent:

6388084, May 14, 2002
Filed:

Nov 21, 2000
Appl. No.:

09/717684
Inventors:

Gerald Lewis Kaplan - New York NY
Achyutharao Sidduri - Livingston NJ
Jefferson Wright Tilley - North Caldwell NJ
Assignee:

Hoffmann-La Roche Inc. - Nutley NJ
International Classification:

C07D21172
US Classification:

546291
Abstract:

Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

4-Pyridinyl-N-Acyl-L-Phenylalanines
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US Patent:

6916933, Jul 12, 2005
Filed:

Sep 24, 2003
Appl. No.:

10/670182
Inventors:

Gerald Lewis Kaplan - New York NY, US
Achyutharao Sidduri - Livingston NJ, US
Jefferson Wright Tilley - North Caldwell NJ, US
Assignee:

Hoffman-La Roche Inc. - Nutley NJ
International Classification:

C07D213/70
C07D211/72
C07D417/00
C07D401/00
C07D405/00
US Classification:

546291, 546300, 5462687, 5462697, 5462691, 5462711, 5462714, 5462721, 5462724, 5462727, 5462764, 5462801, 5462804, 5462821, 546301, 546303, 546194, 544 66, 544131, 544360
Abstract:

Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

4-Dimethylaminobutyric Acid Derivatives
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US Patent:

8344027, Jan 1, 2013
Filed:

Apr 28, 2009
Appl. No.:

12/430934
Inventors:

Mirjana Andjelkovic - Basel, CH
Simona M. Ceccarelli - Basel, CH
Odile Chomienne - Altkirch, FR
Gerald Lewis Kaplan - New York NY, US
Patrizio Mattei - Riehen, CH
Jefferson Wright Tilley - North Caldwell NJ, US
Assignee:

Hoffmann-La Roche Inc. - Nutley NJ
International Classification:

A61K 31/195
C07C 229/00
US Classification:

514563, 562561, 562564
Abstract:

This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formula.

4-Pyridinyl-N-Acyl-L-Phenylalanines
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US Patent:

20020133015, Sep 19, 2002
Filed:

Jan 29, 2002
Appl. No.:

10/059618
Inventors:

Gerald Kaplan - New York NY, US
Achyutharao Sidduri - Livingston NJ, US
Jefferson Tilley - North Caldwell NJ, US
International Classification:

C07D417/02
C07D413/02
C 07D 4 3/02
C 07D 4 1/02
US Classification:

546/261000, 546/276400, 544/238000, 544/333000, 544/405000, 546/269700, 546/271400
Abstract:

Compounds of Formula I have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and are useful for treating disease whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.

4-Dimethylaminobutyric Acid Derivatives
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US Patent:

20120289554, Nov 15, 2012
Filed:

Jul 24, 2012
Appl. No.:

13/556250
Inventors:

Mirjana Andjelkovic - Basel, CH
Simona M. Ceccarelli - Basel, CH
Odile Chomienne - Altkirch, FR
Gerald Lewis Kaplan - New York NY, US
Patrizio Mattei - Riehen, CH
Jefferson Wright Tilley - North Caldwell NJ, US
International Classification:

A61K 31/197
C07C 235/20
C07C 233/51
C07D 333/24
C07D 277/30
C07D 213/56
C07C 317/28
C07C 317/32
C07C 231/14
C07C 275/16
A61K 31/381
A61K 31/426
A61K 31/4406
C07C 315/04
C07C 273/18
A61P 3/10
A61P 3/04
A61P 9/12
A61P 3/00
A61P 3/06
A61P 9/10
A61P 9/04
A61P 13/12
C07C 235/12
US Classification:

514357, 562448, 549 76, 548204, 546335, 562430, 562439, 514563, 514438, 514365, 514562
Abstract:

This invention relates to novel 4-dimethylaminobutyric acid derivatives of the formulawherein A, A, R, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments in methods for the treatment of diseases modulated by CPT2 inhibitors.

Respiration Monitor
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US Patent:

39939952, Nov 23, 1976
Filed:

Dec 8, 1975
Appl. No.:

5/638847
Inventors:

Gerald Stanley Kaplan - Lawrenceville NJ
Alvin Seymour Clorfeine - Adelphi MD
Assignee:

RCA Corporation - New York NY
International Classification:

A61B 508
G01S 904
US Classification:

343 7ED
Abstract:

An apparatus for automatically monitoring the respiration of a subject requiring no physical connection to the subject. The use of such apparatus for automatically triggering an x-ray machine at instants of respiration extrema is also disclosed.

Dual Mode Automobile Collision Avoidance Radar
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US Patent:

40030490, Jan 11, 1977
Filed:

Jul 3, 1975
Appl. No.:

5/593016
Inventors:

Fred Sterzer - Princeton NJ
Gerald Stanley Kaplan - Lawrenceville NJ
Assignee:

RCA Corporation - New York NY
International Classification:

G01S 956
G01S 946
US Classification:

343 6R
Abstract:

A frequency-modulated continuous-wave collision avoidance radar responsive to both reply signals from cooperating (tagged) targets and to skin reflections from proximate non-cooperating (non-tagged) targets.

Adaptive Parameter Processor For Continuous Wave Radar Ranging Systems
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US Patent:

39684920, Jul 6, 1976
Filed:

Dec 26, 1974
Appl. No.:

5/536558
Inventors:

Gerald Stanley Kaplan - Trenton NJ
Assignee:

RCA Corporation - New York NY
International Classification:

G01S 924
US Classification:

343 14
Abstract:

An adaptive parameter signal processor for continuous wave radar ranging systems which provides non-quantized measurements of range. Means are provided to select a suitable portion of the difference frequency wave form, excluding any phase reversal. The period of the difference frequency is measured using the selected portion of the waveform and is converted to frequency. The frequency is, in turn, converted to range. The system parameters are automatically adjusted in accordance with the difference frequency waveform.