The present invention relates to novel 3-heteroarylidene-2-indolinone compounds and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Heteroarylcarboxamide Compounds Active Against Protein Tyrosine Kinase Related Disorders
Gerald McMahon - Kenwood CA Peng Cho Tang - Moraga CA Laura Kay Shawver - San Francisco CA Klaus Peter Hirth - San Francisco CA
Assignee:
Sugen, Inc. - South San Francisco CA
International Classification:
A61K 31443
US Classification:
514340, 5462721
Abstract:
The present invention relates to novel heteroaryl-carboxamides which modulate the activity of protein tyrosine kinases and therefore are expected to be useful in the treatment of abnormal protein tyrosine kinase activity driven disorders including cancer.
Isoxazole-4-Carboxamide Compounds Active Against Protein Tryosine Kinase Related Disorders
Gerald McMahon - Kenwood CA Peng Cho Tang - Moraga CA Laura Kay Shawver - San Francisco CA Klaus Peter Hirth - San Francisco CA
Assignee:
Sugen, Inc. - Redwood City CA
International Classification:
A61K 3142 C07D26108 C07D26112
US Classification:
514378
Abstract:
The present invention relates to novel isoxazole-4-carboxamides which modulate the activity of protein tyrosine kinases and therefore are expected to be useful in the treatment of abnormal protein tyrosine kinase activity driven disorders including cancer.
Dr. McMahon graduated from the SUNY Upstate Medical University in 1986. He works in Syracuse, NY and specializes in Internal Medicine. Dr. McMahon is affiliated with St Josephs Hospital Health Center and Upstate University Hospital Community Campus.
Shenelle Wallace (1989-1993), George Ross (1975-1979), Patty Markham (1961-1965), Frank Smith (1964-1968), Hector Chavez (1971-1975), Gerald McMahon (1957-1961)