Gerald B Wertheim

US Patent:

20090170797, Jul 2, 2009

Filed:

Sep 22, 2005

Appl. No.:

11/918640

Inventors:

Lewis A. Chodosh - West Chester PA, US
Gerald Wertheim - Swarthmore PA, US
Thomas W. Yang - Long Island NY, US

International Classification:

A61K 31/7105
C12Q 1/68
C12Q 1/02

US Classification:

514 44, 435 6, 435 29

Abstract:

This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the role of HUNK in tumor metastasis, primary tumor development, and the prediction of tumor behavior.

US Patent:

20170275686, Sep 28, 2017

Filed:

Aug 21, 2015

Appl. No.:

15/504061

Inventors:

- Philadelphia PA, US
Stephen Master - Philadelphia PA, US
Gerald Wertheim - Philadelphia PA, US
Marlise Luskin - Philadelphia PA, US

International Classification:

C12Q 1/68
C12P 19/34
C07H 21/04

Abstract:

The presently disclosed subject matter provides high-throughput methods for performing genomic DNA methylation assessments. The presently disclosed subject matter further provides methods for diagnosing a subject with a disease and/or disorder, and for determining the prognosis of a subject that has a disease and/or disorder. In certain embodiments, the present disclosure provides a diagnostic method that includes obtaining a biological sample from the subject; determining the methylation status of one or more genomic DNA loci in one or more cells of the biological sample; and diagnosing a disease and/or disorder in the subject, wherein the methylation status of the one or more genomic DNA loci indicates the presence of the disease and/or disorder in the subject.

US Patent:

20140234321, Aug 21, 2014

Filed:

Feb 7, 2014

Appl. No.:

14/175187

Inventors:

- Philadelphia PA, US
Gerald Wertheim - Swarthmore PA, US
Thomas W. Yang - Long Island City NY, US

Assignee:

The Trustees of The University of Pennsylvania - Philadelphia PA

International Classification:

C12Q 1/68
C12N 15/113
G01N 33/50
G01N 33/574

US Classification:

4241391, 435 614, 435 611, 514 44 A, 435 612, 506 9, 435 74, 435 15, 435 613

Abstract:

This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the role of HUNK in tumor metastasis, primary tumor development, and the prediction of tumor behavior.