German Belisario Fuentes

US Patent:

59808390, Nov 9, 1999

Filed:

Feb 11, 1998

Appl. No.:

9/022047

Inventors:

Milan Bier - Tucson AZ
German Eduardo Fuentes - Tucson AZ
Rodolfo Bacheleir Marquez - Tucson AZ
Anthony Ralph Ford - Tucson AZ

Assignee:

Protein Technologies, Inc. - Tucson AZ

International Classification:

B01J 808

US Classification:

422209

Abstract:

The objective of combinatorial chemical synthesis is the preparation of a very large number of different molecular entities by a randomized process of sequential chemical syntheses. The present invention provides a combinatorial vessel comprising a reaction region and a mixing region, adjacent to each other, which can be used to practice combinatorial chemical synthesis. The reaction region comprises a plurality of reaction cavities, in which a plurality of different chemical reactions may be performed simultaneously on resin beads. The resin beads are then transferred to the mixing region and mixed into a single group. Then, the resin beads are transferred into the reaction cavities. The process of performing reactions, transferring to the mixing region, mixing, and transferring to the reaction region can be repeated multiple times to obtain a large number of resin beads, each of which has been exposed to a series of reactions different from most of the other resin beads.