Gisela Magdalena Vaitaitis

US Patent:

20200297795, Sep 24, 2020

Filed:

Mar 23, 2020

Appl. No.:

16/827523

Inventors:

- Denver CO, US
Martin Glenn Yussman - Denver CO, US
Charles W. Henry - Denver CO, US
Gisela M. Vaitaitis - Centennial CO, US

Assignee:

OP-T LLC - Denver CO

International Classification:

A61K 38/08
A61K 45/06
A61K 38/07
A61K 38/10
A61P 25/28

Abstract:

Methods and materials for treating and preventing autoimmune diseases, in particular, multiple sclerosis (MS) including small peptides are capable of interacting with CD40, thereby altering and/or modulating the ability of CD40 to interact with CD154, which apparently affects inflammation; and/or the use of such peptides in reducing the inflammatory response, and in particular, the autoimmune inflammatory response; and/or the use of such short peptides to prevent or reverse autoimmune disease, and particularly, multiple sclerosis, in individuals; and/or methods and materials for detecting T-cells that express CD40 (Th40 cells). Also provided are kits for reducing inflammation, treating autoimmune diseases, or detecting Th40 cells. Additionally, methods and apparatuses to administer the peptide are provided.