Richard Feldman - El Cerrito CA, US Ji-Yun Kim - Berkeley CA, US Haiyan Jiang - San Francisco CA, US Kirk Mclean - Orinda CA, US Junliang Pan - Moraga CA, US Glenn Pierce - Rancho Santa Fe CA, US James Wu - El Cerrito CA, US Xiao-Yan Zhao - Union City CA, US
Assignee:
BAYER HEALTHCARE LLC - Tarrytown NY
International Classification:
A61K 38/36 C07K 14/745 C07K 14/755 A61P 7/00
US Classification:
514 137, 530381, 530383
Abstract:
Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.
Fviii Muteins For Treatment Of Von Willebrand Disease
Haiyan Jiang - San Francisco CA, US Glenn Pierce - Rancho Santa Fe CA, US John E. Murphy - Berkeley CA, US Junliang Pan - Moraga Town CA, US Xin Zhang - San Diego CA, US Tongyao Liu - Alameda CA, US
Assignee:
BAYER HEALTHCARE LLC - Tarrytown NY
International Classification:
A61K 38/48 A61P 7/00 A61P 7/04 C12N 9/96
US Classification:
424 943, 435188
Abstract:
This invention relates to treatment of von Willebrand Disease by administration of Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties in subjects lacking von Willebrand Factor.
Targeted Coagulation Factors And Method Of Using The Same
- WHIPPANY NJ, US Ji-Yun KIM - Berkeley CA, US Haiyan JIANG - San Francisco CA, US Kirk MCLEAN - Orinda CA, US Junliang PAN - Moraga CA, US Glenn PIERCE - La Jolla CA, US James WU - El Cerrito CA, US Xiao-Yan ZHAO - Union City CA, US
International Classification:
C07K 14/755 C07K 16/28
Abstract:
Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.
Targeted Coagulation Factors And Method Of Using The Same
- Whippany NJ, US Ji-Yun Kim - Berkeley CA, US Haiyan Jiang - San Francisco CA, US Kirk Mclean - Orinda CA, US Junliang Pan - Moraga CA, US Glenn Pierce - Rancho Santa Fe CA, US James Wu - El Cerrito CA, US Xiao-Yan Zhao - Union City CA, US
International Classification:
C07K 14/755
US Classification:
530383, 536 235, 435 696, 435358, 435369, 435352
Abstract:
Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.
Name / Title
Company / Classification
Phones & Addresses
Glenn Pierce Manager
Glenn's Carpentry Services LLC Services-Misc
3960 Oakus Dr, Milton, FL 32583
Glenn R. Pierce President, President, Director, Director / President
Pacific Charter School Development, Inc Real Estate Investment Trust
(213)5424700
Glenn Pierce CTO
AVIGEN, INC Research and Development in the Physical, Engineering, and L · Research & Development in Biotechnology · Pharmaceutical Research Labora
1301 Hbr Bay Pkwy, Alameda, CA 94502 (510)7487150, (510)7487155, (510)7487372, (510)7484959
Glenn Pierce (1958-1962), David Allen (1966-1970), Kevin Colston (1969-1973), Eva Curtis (1964-1968), Clyde Harris (1958-1962), Joyce Peplinski (1960-1964)