Goncalo R Abecasis

US Patent:

20090203001, Aug 13, 2009

Filed:

Aug 25, 2008

Appl. No.:

12/197855

Inventors:

Anand Swaroop - Ann Arbor MI, US
Goncalo Abecasis - Ann Arbor MI, US
Mingyao Li - Philadelphia PA, US
Atsuhiro Kanda - Ann Arbor MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers (e.g., polymorphisms and/or haplotypes) for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications.

US Patent:

20110014716, Jan 20, 2011

Filed:

Jul 12, 2010

Appl. No.:

12/834529

Inventors:

Anand Swaroop - Gaithersburg MD, US
Goncalo Abecasis - Ann Arbor MI, US
Wei Chen - Ann Arbor MI, US
Dwight Stambolian - Sewell NJ, US
Albert O. Edwards - Eugene OR, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
Mayo Foundation for Medical Education and Research - Rochester MN
The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

G01N 33/48

US Classification:

436 94

Abstract:

The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications.

US Patent:

20110046202, Feb 24, 2011

Filed:

Jun 19, 2008

Appl. No.:

12/665602

Inventors:

Miriam Fleur Moffat - London, GB
William Osmond Charles Cookson - London, GB
Ivo Glynne Gut - Evry, FR
Gregory Mark Lathrop - Evry, FR
Michael Kabesch - Munich, DE
Martin Farral - Oxford, GB
Goncalo Rocha Abecasis - Ann Arbor MI, US
Liming Liang - Ann Arbor MI, US

International Classification:

A61K 31/713
C12Q 1/68
C40B 30/04
A61P 11/06
A61P 37/08

US Classification:

514 44 A, 435 6, 506 9

Abstract:

The present invention concerns a method of testing a subject thought to have or be predisposed to having asthma, allergy, atopic disease or atopic sensitization, which comprises the step of analyzing a biological sample from said subject for (i) detecting the presence of a mutation associated with the over-expression of the ORMDL3 gene, and/or (ii) analyzing the expression of the ORMDL3 gene; a use, for treating and/or preventing asthma, allergy, atopic disease or atopic sensitization in a subject, of a compound which specifically inhibits the expression of the ORMDL3 gene; and an in vitro method of selecting a compound, which can be useful for treating asthma, allergy, atopic disease or atopic sensitization, characterized in that said method comprises the steps of: (a) obtaining a cell expressing the ORMDL3 gene, (b) contacting said cell with at least one compound, (c) comparing the expression of the ORMDL3 gene in the cell between the steps a) and b), and (d) selecting the compound, which induces a lower level of expression of the ORMDL3 gene in the cell contacted to that compound.

US Patent:

20120135884, May 31, 2012

Filed:

Jan 12, 2012

Appl. No.:

13/349337

Inventors:

Anand Swaroop - Gaithersburg MD, US
Goncalo Abecasis - Ann Arbor MI, US
Wei Chen - Ann Arbor MI, US
Dwight Stambolian - Sewell NJ, US
Albert O. Edwards - Eugene OR, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - Philadelphia PA
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN

International Classification:

C40B 30/04
C12Q 1/68

US Classification:

506 9, 435 611

Abstract:

The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications.

US Patent:

20130266937, Oct 10, 2013

Filed:

Mar 5, 2013

Appl. No.:

13/785942

Inventors:

Anand Swaroop - Ann Arbor MI, US
Goncalo Abecasis - Ann Arbor MI, US
Atsuhiro Kanda - Ann Arbor MI, US
Mingyao Li - Philadelphia PA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

International Classification:

C12Q 1/68

US Classification:

435 611

Abstract:

The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers (e.g., polymorphisms and/or haplotypes) for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications.

US Patent:

20220370489, Nov 24, 2022

Filed:

Feb 23, 2022

Appl. No.:

17/678792

Inventors:

- Tarrytown NY, US
Ying Hu - Tarrytown NY, US
Kavita Praveen - Tarrytown NY, US
Giovanni Coppola - Tarrytown NY, US
Goncalo Abecasis - Tarrytown NY, US
Aris Baras - Tarrytown NY, US
Carmelo Romano - Tarrytown NY, US

International Classification:

A61K 31/713
A61K 45/06
C12Q 1/6883
A61P 27/06

Abstract:

The present disclosure provides methods of treating subjects having inflammation with an Angiopoietin-Like 7 (ANGPTL7) inhibitor and a glucocorticoid, methods of decreasing glucocorticoid-induced ophthalmic conditions in subjects, and methods of identifying subjects having an increased risk of developing glucocorticoid-induced ophthalmic conditions.

US Patent:

20220177982, Jun 9, 2022

Filed:

Dec 3, 2021

Appl. No.:

17/541602

Inventors:

- Tarrytown NY, US
Julie Horowitz - Tarrytown NY, US
Manuel Allen Revez Ferreira - Tarrytown NY, US
Goncalo Abecasis - Tarrytown NY, US
Aris Baras - Tarrytown NY, US
Amy Damask - Tarrytown NY, US

International Classification:

C12Q 1/70
C12Q 1/6827

Abstract:

Methods of treating subjects having a coronavirus infection, and methods of identifying subjects having an increased risk of a coronavirus infection are provided herein.

US Patent:

20230074721, Mar 9, 2023

Filed:

Aug 24, 2022

Appl. No.:

17/821806

Inventors:

- Tarrytown NY, US
Joshua Backman - Tarrytown NY, US
Alexander Li - Tarrytown NY, US
Lauren Gurski - Tarrytown NY, US
Julie E. Horowitz - Tarrytown NY, US
Katherine Siminovitch - Tarrytown NY, US
Goncalo Abecasis - Tarrytown NY, US
Aris Baras - Tarrytown NY, US

International Classification:

C12N 15/113
C12Q 1/6883
A61P 29/00

Abstract:

The present disclosure provides methods of treating subjects having an inflammatory disease, and methods of identifying subjects having an increased risk of developing an inflammatory disease.