Gordon Lewis Epstein

US Patent:

6394975, May 28, 2002

Filed:

May 28, 1997

Appl. No.:

08/863883

Inventors:

Gordon H. Epstein - Fremont CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61M 300

US Classification:

604 43, 604 82, 604289, 604290, 604311, 604313, 604902, 2221452

Abstract:

A process and apparatus for one-step preparation of fibrinogen adhesive by polyethylene glycol-mediated precipitation from plasma are disclosed. The methods and apparatus of the invention permit preparation of autologous fibrinogen adhesive composition from the patient during surgery, and can be applied generally to provide such compositions. Also disclosed are an apparatus and method for application of sealant comprising this fibrinogen adhesive composition.

US Patent:

6432084, Aug 13, 2002

Filed:

May 8, 2000

Appl. No.:

09/566452

Inventors:

Mitchell E. Levinson - Pleasanton CA
Gordon H. Epstein - Fremont CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61M 100

US Classification:

604118

Abstract:

A spray applicator particularly suited to needs of surgeons for dispensing a multi-component fluid, for example fibrin and thrombin components of a tissue adhesive. The spray applicator having a spray nozzle, a liquid dispensing aperture, a spray plate to be impacted by the liquid dispensed and a gas nozzle to provide a stream of carrier gas to carry the dispensed liquid away from the spray plate to form a spray.

US Patent:

D462437, Sep 3, 2002

Filed:

Mar 6, 1998

Appl. No.:

29/084634

Inventors:

Gordon Howard Epstein - Fremont CA
Alan Kirby Plyley - Goleta CA
Russell James Redmond - Goleta CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

2401

US Classification:

D24108

US Patent:

D462758, Sep 10, 2002

Filed:

Mar 6, 1998

Appl. No.:

29/084650

Inventors:

Gordon Howard Epstein - Fremont CA
Alan Kirby Plyley - Goleta CA
Russell James Redmond - Goleta CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

2401

US Classification:

D24108

US Patent:

6461361, Oct 8, 2002

Filed:

Apr 30, 1999

Appl. No.:

09/302726

Inventors:

Gordon Howard Epstein - Fremont CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61M 3700

US Classification:

606 82, 239310, 2221452, 2221455

Abstract:

A gas-driven spray applicator particularly suitable for spray delivery of mixed fibrin sealants for surgical use has a spray nozzle wherein droplets or a stream of mixed sealant agents are entrained in a stream of gas such as sterile compressed air. Gas entrainment of the mixed sealant overcomes problems of ineffective mixing which may occur when the sealant agents are separately discharged into overlapping spray patterns. A spray tip assembly is disclosed which is suitable for attachment to an applicator body having manually dischargeable reservoirs for the sealant agents. Clogs may be cleared by suction.

US Patent:

6464712, Oct 15, 2002

Filed:

Mar 20, 2000

Appl. No.:

09/528574

Inventors:

Gordon H. Epstein - Fremont CA
Todd E. Lempert - Piedmont CA
Brian B. Martin - Boulder Creek CA
David M. Taylor - Fremont CA
Richard M. Romley - Alameda CA

Assignee:

BioInterventional Corporation - Pleasanton CA

International Classification:

A61B 1708

US Classification:

606213

Abstract:

A device for expansion within a blood vessel having a wall defining a lumen in the body. The device comprises an elongated tubular member having proximal and distal extremities and having a longitudinal axis. An expansile member is carried by the distal extremity of the elongated tubular member and is movable between contracted and expanded configurations. A deformable membrane having proximal and distal outer surfaces at least partially covers the expansile member in the expanded configuration. The proximal and distal outer surfaces have substantially different configurations when the expansile member is in the expanded configuration. Deployment tool is carried by the proximal extremity of the elongated tubular member and is coupled to the expansile member for moving the expansile member between the contracted and expanded configurations. A handle assembly is carried by the proximal extremity of the elongated tubular member and coupled to said deployment tools.

US Patent:

6471667, Oct 29, 2002

Filed:

Oct 25, 1999

Appl. No.:

09/426353

Inventors:

Gordon Howard Epstein - Fremont CA

Assignee:

Baxter International Inc. - Deerfield IL

International Classification:

A61M 100

US Classification:

604 28, 604119, 604 35, 604 30, 604 57, 604 45, 604 33, 1376254, 251322

Abstract:

A medical fluid suctioning device for selectively applying varied levels of suction pressure at a device-tissue interface includes a direct âtrumpetâ-type control mechanism in conjunction with a âventuriâ-type control. A valve manifold is adapted to couple a vent pathway and a suction pathway simultaneously to the vacuum conduit adapted for connection to a vacuum source. The amount of resistance to flow due to vacuum pressure is adjusted simultaneously in both the vent pathway and the suction pathway in order to achieve controlled, selected levels of suction. Similarly shaped valve apertures are provided in inverse and reciprocal orientation along an axis of motion of a valve manifold. The apertures translate across ports to the suction and venting pathways simultaneously to vary applied suction to those pathways inversely. The shaped valve apertures preferably have diminished elliptical shapes having an elongate axis with an increasing cross-sectional area going from a transverse short axis to a transverse wide axis along the axis of motion of the valve manifold.

US Patent:

6488650, Dec 3, 2002

Filed:

Dec 8, 1999

Appl. No.:

09/456728

Inventors:

Gordon Howard Epstein - Fremont CA
Mitchell E. Levinson - Pleasanton CA
Richard Spero - Brentwood CA
Adam Hagmann - Brentwood CA

Assignee:

Baxter International, Inc. - Deerfield IL

International Classification:

A61M 3700

US Classification:

604 82, 606214, 222129

Abstract:

A filling device and method, particularly for two-component sealants such as fibrin sealants, which enables two fluids to be separately and directly filled to the reservoirs of a dual syringe fluid applicator from two storage containers, which can be standardized, sealed, sterilized bottles. The device has a connector which engages with the fluid applicator, is keyed to orient the applicators fluid reservoirs in a predetermined manner and holds the containers in side-by-side alignment with the applicator. Two fluid conduits whose downward ends may be pointed to pierce seals on the bottles, extend between the applicator and the bottles and can each have a transverse reach to accommodate the girth of the bottles. The bottles may be tilted by the device to enable the conduits to draw maximal fluid from a lowermost point of the bottle. Tilting can be effected by a downward movement of the device supporting the applicator which movement can introduce the fluid conduits into the bottles.