J Craig Venter Institute Inc Noncommercial Research Organizations
9704 Medical Center Dr, Rockville, MD 20850
Granger Sutton Senior Director Informatics
J. Craig Venter Institute Biotechnology · Commercial Physical Research · Noncommercial Research Organization Commercial Physical Research · Noncommercial Research Organization
9704 Medical Ctr Dr, Rockville, MD 20850 9712 Medical Ctr Dr, Rockville, MD 20850 (301)7957000, (301)3099192, (240)2682757, (301)8380200
A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
Yi Li - Gaithersburg MD, US Liang Cao - Monmouth Terrace, HK Jian Ni - Gaithersburg MD, US Reiner Gentz - Silver Spring MD, US Carol Bult - Laurel MD, US Granger Sutton - Columbia MD, US Craig Rosen - Laytonsville MD, US
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.
A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
Polynucleotide Encoding A Human Chemotactic Protein
Haodong Li - Gaithersburg MD Steven M. Ruben - Olney MD Granger G. Sutton - Columbia MD
Assignee:
Human Genome Sciences, Inc. - Rockville MD
International Classification:
C07K 14475 C07K 1452 C12N 1519 C12N 1563
US Classification:
435 695
Abstract:
A human chemotactic protein polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating for stem cell mobilization, myeloprotection and neuronal protection, to treat tumors, to promote wound healing, to combat parasitic infection and to regulate hematopoiesis. Also disclosed are antagonists against such polypeptides which may be employed to treat rheumatoid arthritis, lung inflammation, allergy, infectious diseases and to prevent inflammation and atherosclerosis. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
Polynucleotides Encoding A Human Chemotactic Protein
Haodong Li - Gaithersburg MD Steven M. Ruben - Olney MD Granger Sutton - Columbia MD
Assignee:
Human Genome Sciences, Inc. - Rockville MD
International Classification:
C12N 120 C12N 510 C12N 1512 C12N 1519
US Classification:
536 235
Abstract:
A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
Ying-Fei Wei - Darnestown MD Granger G. Sutton - Columbia MD
Assignee:
Human Genome Sciences, Inc. - Rockville MD
International Classification:
C12N 500 C12N 1500 C12P 2106 C07H 1700
US Classification:
435325
Abstract:
A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.
Polynucleotides Encoding Human G-Protein Coupled Receptor Gpr1
Yi Li - Gaithersburg MD Liang Cao - Hong Kong, HK Jian Ni - Gaithersburg MD Reiner Gentz - Silver Spring MD Carol J. Bult - Laurel MD Granger G. Sutton - Columbia MD Craig A. Rosen - Laytonsville MD
Assignee:
Human Genome Sciences, Inc. - Rockville MD
International Classification:
C12N 510 C12N 1512 C12N 1562
US Classification:
435 691
Abstract:
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
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