Greg Louis Palmer

US Patent:

20190271703, Sep 5, 2019

Filed:

Oct 26, 2017

Appl. No.:

16/345422

Inventors:

- Durham NC, US
Gabi Hanna - Durham NC, US
Greg Palmer - Durham NC, US
Andrew J. Armstrong - Durham NC, US
Donald P. McDonnell - Durham NC, US

International Classification:

G01N 33/574
C07K 16/28
A61K 45/06
A61P 35/04
A61K 39/395
A61K 47/68

Abstract:

The current disclosure relates to biomarkers for chemo-residual tumor cells cancer in a subject and methods of treating same.

US Patent:

20180133319, May 17, 2018

Filed:

Dec 22, 2017

Appl. No.:

15/852598

Inventors:

- Durham NC, US
Brant A. Inman - Durham NC, US
Paolo Maccarini - Durham NC, US
Greg Palmer - Durham NC, US
Yang Liu - Durham NC, US
Douglas Weitzel - Durham NC, US

International Classification:

A61K 41/00
A61P 35/00
A61P 35/04
A61K 9/51
A61K 33/24
A61K 39/395
A61K 9/00
A61K 47/69
A61P 35/02
A61N 5/06
A61N 1/40
A61N 5/02
A61B 18/20
A61B 18/14
A61B 18/18

Abstract:

The presently disclosed subject matter is directed to a method of treating cancer, such as (but not limited to) metastatic bladder and breast cancer. The disclosed method comprises using two treatment modalities to synergistically treat primary and secondary tumor cells in a subject. The first element of the method comprises administering a therapeutically effective amount of a plasmonics-active metal nanoparticle to a subject comprising a primary cancer and a distant metastatic site, wherein the nanoparticle concentrates at the primary cancer. The method further comprises exposing the subject to photon radiation at the site of the primary cancer. The second element of the disclosed method comprises administering a therapeutically effective amount of an immune checkpoint modulator to the subject. The synergistic combination provides a rapid, safe, and effective treatment of local and distant lesions, better than each modality alone.