Gregoire M Cardoen from 1217 Sugarberry Ln, Collegeville, PA 19426, age 45

Polymer Micelles Containing Anthracylines For The Treatment Of Cancer
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US Patent:

20100278928, Nov 4, 2010
Filed:

Apr 30, 2010
Appl. No.:

12/771676
Inventors:

Kevin N. Sill - Tampa FL, US
Jonathan Rios-Doria - Land O Lakes FL, US
Habib Skaff - Tampa FL, US
Gregoire Cardoen - Tampa FL, US
Assignee:

Intezyne Technologies, Incorporated - Tampa FL
International Classification:

A61K 9/16
A61K 31/35
A61P 35/04
US Classification:

424497, 514459
Abstract:

The present invention provides micelles having an anthracycline encapsulated therein, the micelles comprising a multiblock copolymer. The invention further provides methods of preparing and using said micelles, and compositions thereof.

Polymer Micelles Containing Sn-38 For The Treatment Of Cancer
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US Patent:

20100278932, Nov 4, 2010
Filed:

May 4, 2010
Appl. No.:

12/773702
Inventors:

Kevin N. Sill - Tampa FL, US
Habib Skaff - Tampa FL, US
Adam Carie - Ruskin FL, US
Jonathan Rios-Doria - Land O Lakes FL, US
Richard Slama - Tampa FL, US
Gregoire Cardoen - Tampa FL, US
Assignee:

Intezyne Technologies, Incorporated - Tampa FL
International Classification:

A61K 9/50
A61K 31/4375
US Classification:

424501, 514283
Abstract:

The present invention provides micelles having SN-38 encapsulated therein.

Pegylated Polyplexes For Polynucleotide Delivery
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US Patent:

20110142886, Jun 16, 2011
Filed:

Dec 1, 2010
Appl. No.:

12/958386
Inventors:

JANNI MIROSEVICH - TAMPA FL, US
GREGOIRE CARDOEN - PHILADELPHIA PA, US
KEVIN N. SILL - TAMPA FL, US
Assignee:

INTEZYNE TECHNOLOGIES, INCORPORATED - TAMPA FL
International Classification:

A61K 9/00
C07K 14/00
C07K 2/00
A61K 31/713
A61K 31/711
A61K 31/7105
A61P 29/00
A61P 19/02
A61P 9/06
A61P 9/10
A61P 31/12
A61P 31/04
A61P 35/00
A61P 3/10
A61P 31/10
A61P 25/28
A61P 25/08
A61P 25/16
A61P 25/24
A61P 25/06
A61P 9/12
A61P 15/00
A61P 1/00
A61P 37/08
A61P 25/22
A61P 25/18
A61P 27/06
A61P 25/02
A61P 13/00
US Classification:

424400, 530358, 530322, 514 44 A, 514 44 R
Abstract:

The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.

Poly(Ethylene Glycol) Derivatives For Metal-Free Click Chemistry
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US Patent:

20110224383, Sep 15, 2011
Filed:

Mar 11, 2011
Appl. No.:

13/045996
Inventors:

Kevin N. Sill - Tampa FL, US
Gregoire Cardoen - Philadelphia PA, US
Assignee:

INTEZYNE TECHNOLOGIES, INC. - Tampa FL
International Classification:

C08G 65/333
C08G 65/332
C08G 65/335
C08G 65/337
US Classification:

525404, 525408, 525403, 525406, 525405
Abstract:

The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.

Pegylated Polyplexes For Polynucleotide Delivery
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US Patent:

20110229528, Sep 22, 2011
Filed:

Mar 14, 2011
Appl. No.:

13/047733
Inventors:

JANNI MIROSEVICH - TAMPA FL, US
KEVIN N. SILL - TAMPA FL, US
GREGOIRE CARDOEN - PHILADELPHIA PA, US
Assignee:

INTEZYNE TECHNOLOGIES, INCORPORATED - TAMPA FL
International Classification:

A61K 9/00
A61K 38/02
A61K 38/22
A61K 38/40
A61K 31/7088
A61K 31/713
A61K 48/00
US Classification:

424400, 514 11, 514 96, 514 135, 514 44 R, 514 44 A
Abstract:

The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.

Pegylated Polyplexes For Polynucleotide Delivery
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US Patent:

20120148631, Jun 14, 2012
Filed:

Jun 1, 2011
Appl. No.:

13/150640
Inventors:

Janni Mirosevich - Tampa FL, US
Gregoire Cardoen - Philadelphia PA, US
Kevin N. Sill - Tampa FL, US
Assignee:

Intezyne Technologies, Incorporated - Tampa FL
International Classification:

A61K 31/7088
A61K 9/00
A61K 31/713
C08G 69/00
US Classification:

424400, 528354, 514 44 R, 514 44 A
Abstract:

The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.

Polymeric Micelles For Polynucleotide Encapsulation
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US Patent:

20130266617, Oct 10, 2013
Filed:

Aug 21, 2012
Appl. No.:

13/591122
Inventors:

Janni Mirosevich - Tampa FL, US
Gregoire Cardoen - Tampa FL, US
Kevin N. Sill - Tampa FL, US
Habib Skaff - Tampa FL, US
Assignee:

Intezyne Technologies, Inc. - Tampa FL
International Classification:

A61K 47/34
US Classification:

424400, 514 44 R
Abstract:

The present invention provides micelles having a polynucleotide encapsulated therein, the micelle comprising copolymers comprising hydrophobic moieties in a cationic complexing block. The invention further provides methods of preparing and using said micelles, and compositions thereof.

Pegylated Polyplexes For Polynucleotide Delivery
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US Patent:

20130344117, Dec 26, 2013
Filed:

Mar 13, 2013
Appl. No.:

13/801407
Inventors:

Janni Mirosevich - Tampa FL, US
Kevin N. Sill - Tampa FL, US
Gregoire Cardoen - King of Prussia PA, US
Assignee:

INTEZYNE TECHNOLOGIES, INC - Tampa FL
International Classification:

A61K 48/00
A61K 31/713
A61K 9/50
US Classification:

424400, 514 44 R, 514 44 A
Abstract:

The present invention provides polymers, compositions thereof, and polyplexes comprising said polymers. In particular, cationic polymers, pegylated versions thereof, and polynucleotide containing polyplexes comprising such polymers are provided. The invention further provides methods of using said polymers and polyplexes.