Gregory J Caputo

US Patent:

20130344123, Dec 26, 2013

Filed:

Mar 4, 2013

Appl. No.:

13/784653

Inventors:

Jeffrey HETTINGER - Cherry Hill NJ, US
Robert KRCHNAVEK - Gibbsboro NJ, US
Gregory A. CAPUTO - Glassboro NJ, US

Assignee:

Rowan University - Glassboro NJ

International Classification:

A61K 33/38

US Classification:

424405, 424618

Abstract:

The disclosure relates to coatings that contain silver, either in the form of metallic silver, silver oxides, salts of silver, or combinations of these. The silver is present in a microparticulate or nanoparticulate form, which exerts antimicrobial activity when bacteria (e.g., in a body fluid) contact the coated surface. The coatings are applied through accumulation of silver-containing particles on the surface, such as by sputtering or electron beam vapor deposition. As a result, their thickness, particle size, and density can be controlled. Furthermore, the surface can also be coated with other substances, such as diamond-like carbon or alumina, either as a discrete layer or intermixed with the silver-containing particles.

US Patent:

20130084312, Apr 4, 2013

Filed:

Jun 12, 2012

Appl. No.:

13/494953

Inventors:

Gregory A. CAPUTO - Glassboro NJ, US
Yaquan SUN - Menands NY, US
Lei YU - Cherry Hill NJ, US
Sireesh APPAJOSYULA - Union NJ, US

Assignee:

ROSE PHARMACEUTICALS, LLC - Boca Raton FL

International Classification:

A61K 47/34
C08G 63/91
C08G 63/40

US Classification:

424400, 514363, 514 217, 528307, 5147723, 525437, 977773

Abstract:

Biocompatible polymeric nanoparticles for delivery of bioactive agents, and methods for preparing the particles, are described. Polyoxalate nanoparticles of the subject technology show desired particle sizes suitable for use in drug delivery and a substantially uniform or narrow particle size distribution. The polyoxalate nanoparticles can contain water-soluble, poorly water-soluble, or water-insoluble drugs. The nanoparticles are nontoxic and are generally safe for use in humans. After being administered into the body, the nanoparticles with a high content of a bioactive agent entrapped therein can safely deliver the agent to target sites and stably release the drug at a controlled rate.