Gregory T Garcia

US Patent:

6713444, Mar 30, 2004

Filed:

May 12, 2000

Appl. No.:

09/570023

Inventors:

Gregory E. Garcia - Germantown MD
Richard K. Gordon - Potomac MD
Debbie R. Moorad - Rockville MD
Bhupendra P. Doctor - Potomac MD

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 3800

US Classification:

514 2, 514 13, 514 21, 530324, 530326, 530333, 530344, 4242391, 424 91, 4352527

Abstract:

The compounds of the invention are generally described by the formula: and the salts, esters, amides, and acyl forms thereof. Up to 15 amino acids may be truncated from the N-terminus and up to 6 amino acids may be truncated from the C-terminus. Each position represented by a letter indicates a single amino acid residue wherein B is a basic or polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large or hydrophobic amino acid or a modified form thereof. These compounds may be used to inhibit the protease activity of Botulinum B and tetanus toxins.

US Patent:

7235521, Jun 26, 2007

Filed:

May 15, 2000

Appl. No.:

09/979101

Inventors:

Richard K. Gordon - Potomac MD, US
Deborah R. Moorad - Silver Spring MD, US
Bhupendra P. Doctor - Potomac MD, US
Gregory E. Garcia - Silver Spring MD, US

Assignee:

United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 38/00

US Classification:

514 2, 514 15, 530300, 435 71, 4353201, 536 235, 4242391

Abstract:

The compounds of the invention are generally described by the formula (1): BZ*BZ*X*QFXXXX, (2): BXXXXQFXXXX, or (3): BXBXZQFZXXXand the salts, esters, amides, and acyl forms thereof. Each position represented by a letter indicates a single amino acid residue: B is a basic or polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large or hydrophobic amino acid or a modified form thereof. As described below, one or more of the peptide linkages between the amino acid residues may be replaced by a peptide linkage mimic. These compounds may be used as molecular building blocks to create compounds that are optimized for inhibiting the protease activity of Botulinum B and tetanus toxins.

US Patent:

7375079, May 20, 2008

Filed:

Nov 4, 2005

Appl. No.:

11/268757

Inventors:

Richard K. Gordon - Potomac MD, US
Deborah R. Moorad - Silver Spring MD, US
Bhupendra P. Doctor - Potomac MD, US
Gregory E. Garcia - Silver Spring MD, US

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 38/00

US Classification:

514 2, 514 15, 530300, 435 71, 4353201, 435325, 4242391, 536 235

Abstract:

The compounds of the invention are generally described by the formula:BZ*BZ*X*QFXXXX,   (1)BXXXXQFXXXX, or   (2)BZBXZQFZXXX   (3)and the salts, esters, amides, and acyl forms thereof. Each position represented by a letter indicates a single amino acid residue: B is a basic of polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large of hydrophobic amino acid or a modified form thereof. As described below, one or more of the peptide linkages between the amino acid residues may be replaced by a peptide linkage mimic. These compounds may be used as molecular building blocks to create compounds that are optimized for inhibiting the protease activity of Botulinum b and tetanus toxins.

US Patent:

20030113902, Jun 19, 2003

Filed:

Apr 26, 2000

Appl. No.:

09/558512

Inventors:

Richard Gordon - Potomac MD, US
Bhupendra Doctor - Potomac MD, US
Ashima Saxena - Fairfax VA, US
Shawn Feaster - Damascus MD, US
Donald Maxwell - Baltimore MD, US
Michelle Ross - Edgewood MD, US
David Lenz - Bel Air MD, US
Keith Lejeune - Pittsburgh PA, US
Alan Russell - Wexford PA, US
Gregory Garcia - Germantown MD, US

International Classification:

C12S001/00
A47K007/02
A47L013/16

US Classification:

435/262500, 015/244400

Abstract:

A material comprising a porous support and a plurality of enzymes for the removal, decontamination or neutralization of hazardous chemicals such as OP compounds is disclosed. The material may be used on a variety of surfaces, including natural, synthetic and biological surfaces such as skin and other delicate membranes. Also disclosed is a process of making the material, kits and various methods and reactivation devices for reactivating the enzymatic activity of the material.

US Patent:

20050113304, May 26, 2005

Filed:

May 27, 2004

Appl. No.:

10/854646

Inventors:

Richard Gordon - Potomac MD, US
Deborah Moorad - Silver Spring MD, US
Bhupendra Doctor - Potomac MD, US
Gregory Garcia - Silver Spring MD, US

Assignee:

Army, Government of the United States Department of the Army - Fort Detrick MD

International Classification:

A61K038/08
C07K007/06

US Classification:

514015000, 530327000

Abstract:

The compounds of the invention are generally described by the formula: BZ*BZ*X*QFXXXX  (1), BXXXXQFXXXX  (2), or BZBXZQFZXXX  (3) and the salts, esters, amides, and acyl forms thereof. Each position represented by a letter indicates a single amino acid residue: B is a basic of polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large of hydrophobic amino acid or a modified form thereof. As described below, one or more of the peptide linkages between the amino acid residues may be replaced by a peptide linkage mimic. These compounds may be used as molecular building blocks to create compounds that are optimized for inhibiting the protease activity of Botulinum b and tetanus toxins.

US Patent:

6573244, Jun 3, 2003

Filed:

May 12, 2000

Appl. No.:

09/570022

Inventors:

Richard K. Gordon - Potomac MD
Debbie R. Moorad - Rockville MD
Bhupendra P. Doctor - Potomac MD
Gregory E. Garcia - Germantown MD

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 3800

US Classification:

514 15, 536 231, 536 234, 435 691, 4241851

Abstract:

The compounds of the invention are generally described by the formula: or and the salts, esters, amides, and acyl forms thereof. Each position represented by a letter indicates a single amino acid residue: B is a basic or polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large or hydrophobic amino acid or a modified form thereof. As described below, one or more of the peptide linkages between the amino acid residues may be replaced by a peptide linkage mimic. These compounds may be used as molecular building blocks to create compounds that are optimized for inhibiting the protease activity of Botulinum B and tetanus toxins.