Gregory L Garcia

US Patent:

6713444, Mar 30, 2004

Filed:

May 12, 2000

Appl. No.:

09/570023

Inventors:

Gregory E. Garcia - Germantown MD
Richard K. Gordon - Potomac MD
Debbie R. Moorad - Rockville MD
Bhupendra P. Doctor - Potomac MD

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 3800

US Classification:

514 2, 514 13, 514 21, 530324, 530326, 530333, 530344, 4242391, 424 91, 4352527

Abstract:

The compounds of the invention are generally described by the formula: and the salts, esters, amides, and acyl forms thereof. Up to 15 amino acids may be truncated from the N-terminus and up to 6 amino acids may be truncated from the C-terminus. Each position represented by a letter indicates a single amino acid residue wherein B is a basic or polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large or hydrophobic amino acid or a modified form thereof. These compounds may be used to inhibit the protease activity of Botulinum B and tetanus toxins.

US Patent:

6768298, Jul 27, 2004

Filed:

Jul 17, 2001

Appl. No.:

09/907249

Inventors:

Gopichand Katragadda - San Antonio TX
Douglas Earnest - San Antonio TX
Gregory Anthony Garcia - Pueblo CO
Richard Paul Reiff - Pueblo CO

Assignee:

Transportation Technology Center, Inc. - Pueblo CO

International Classification:

B61K 910

US Classification:

324217

Abstract:

A method and system for detecting transverse cracks beneath horizontal cracks in the rail way track. As a transporter moves over rail, a saturation magnetic field is generated into and across the rail head using a toroidal-shaped DC saturation magnet located a predetermined distance above the rail head. Any transverse cracks in the rail head are detected with a low frequency eddy current probe mounted centrally between the opposing pole ends of the DC magnet and over the rail head. A force is applied to the low frequency eddy current probe to hold the probe towards the rail head as the transporter moves on the rail so as to follow the wear pattern of the rail head and to minimize lift-off. A second sensor is used to sense the presence of non-relevant indications that falsely indicate possible transverse cracks by the low frequency eddy current probe.

US Patent:

7235521, Jun 26, 2007

Filed:

May 15, 2000

Appl. No.:

09/979101

Inventors:

Richard K. Gordon - Potomac MD, US
Deborah R. Moorad - Silver Spring MD, US
Bhupendra P. Doctor - Potomac MD, US
Gregory E. Garcia - Silver Spring MD, US

Assignee:

United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 38/00

US Classification:

514 2, 514 15, 530300, 435 71, 4353201, 536 235, 4242391

Abstract:

The compounds of the invention are generally described by the formula (1): BZ*BZ*X*QFXXXX, (2): BXXXXQFXXXX, or (3): BXBXZQFZXXXand the salts, esters, amides, and acyl forms thereof. Each position represented by a letter indicates a single amino acid residue: B is a basic or polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large or hydrophobic amino acid or a modified form thereof. As described below, one or more of the peptide linkages between the amino acid residues may be replaced by a peptide linkage mimic. These compounds may be used as molecular building blocks to create compounds that are optimized for inhibiting the protease activity of Botulinum B and tetanus toxins.

US Patent:

7375079, May 20, 2008

Filed:

Nov 4, 2005

Appl. No.:

11/268757

Inventors:

Richard K. Gordon - Potomac MD, US
Deborah R. Moorad - Silver Spring MD, US
Bhupendra P. Doctor - Potomac MD, US
Gregory E. Garcia - Silver Spring MD, US

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 38/00

US Classification:

514 2, 514 15, 530300, 435 71, 4353201, 435325, 4242391, 536 235

Abstract:

The compounds of the invention are generally described by the formula:BZ*BZ*X*QFXXXX,   (1)BXXXXQFXXXX, or   (2)BZBXZQFZXXX   (3)and the salts, esters, amides, and acyl forms thereof. Each position represented by a letter indicates a single amino acid residue: B is a basic of polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large of hydrophobic amino acid or a modified form thereof. As described below, one or more of the peptide linkages between the amino acid residues may be replaced by a peptide linkage mimic. These compounds may be used as molecular building blocks to create compounds that are optimized for inhibiting the protease activity of Botulinum b and tetanus toxins.

US Patent:

20030113902, Jun 19, 2003

Filed:

Apr 26, 2000

Appl. No.:

09/558512

Inventors:

Richard Gordon - Potomac MD, US
Bhupendra Doctor - Potomac MD, US
Ashima Saxena - Fairfax VA, US
Shawn Feaster - Damascus MD, US
Donald Maxwell - Baltimore MD, US
Michelle Ross - Edgewood MD, US
David Lenz - Bel Air MD, US
Keith Lejeune - Pittsburgh PA, US
Alan Russell - Wexford PA, US
Gregory Garcia - Germantown MD, US

International Classification:

C12S001/00
A47K007/02
A47L013/16

US Classification:

435/262500, 015/244400

Abstract:

A material comprising a porous support and a plurality of enzymes for the removal, decontamination or neutralization of hazardous chemicals such as OP compounds is disclosed. The material may be used on a variety of surfaces, including natural, synthetic and biological surfaces such as skin and other delicate membranes. Also disclosed is a process of making the material, kits and various methods and reactivation devices for reactivating the enzymatic activity of the material.

US Patent:

20050113304, May 26, 2005

Filed:

May 27, 2004

Appl. No.:

10/854646

Inventors:

Richard Gordon - Potomac MD, US
Deborah Moorad - Silver Spring MD, US
Bhupendra Doctor - Potomac MD, US
Gregory Garcia - Silver Spring MD, US

Assignee:

Army, Government of the United States Department of the Army - Fort Detrick MD

International Classification:

A61K038/08
C07K007/06

US Classification:

514015000, 530327000

Abstract:

The compounds of the invention are generally described by the formula: BZ*BZ*X*QFXXXX  (1), BXXXXQFXXXX  (2), or BZBXZQFZXXX  (3) and the salts, esters, amides, and acyl forms thereof. Each position represented by a letter indicates a single amino acid residue: B is a basic of polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large of hydrophobic amino acid or a modified form thereof. As described below, one or more of the peptide linkages between the amino acid residues may be replaced by a peptide linkage mimic. These compounds may be used as molecular building blocks to create compounds that are optimized for inhibiting the protease activity of Botulinum b and tetanus toxins.

US Patent:

6573244, Jun 3, 2003

Filed:

May 12, 2000

Appl. No.:

09/570022

Inventors:

Richard K. Gordon - Potomac MD
Debbie R. Moorad - Rockville MD
Bhupendra P. Doctor - Potomac MD
Gregory E. Garcia - Germantown MD

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 3800

US Classification:

514 15, 536 231, 536 234, 435 691, 4241851

Abstract:

The compounds of the invention are generally described by the formula: or and the salts, esters, amides, and acyl forms thereof. Each position represented by a letter indicates a single amino acid residue: B is a basic or polar/large amino acid or a modified form thereof; X is a small or hydrophobic amino acid or a modified form thereof; X* is a small or polar/large amino acid or a modified form thereof; Z is a polar/large or hydrophobic amino acid or a modified form thereof; Z* is Proline or a polar/large or hydrophobic amino acid or a modified form thereof. As described below, one or more of the peptide linkages between the amino acid residues may be replaced by a peptide linkage mimic. These compounds may be used as molecular building blocks to create compounds that are optimized for inhibiting the protease activity of Botulinum B and tetanus toxins.

Address:

7334 Hidden Hls N, San Antonio, TX 78244

VIN:

JA32U1FU1AU001129

Make:

MITSUBISHI

Model:

LANCER

Year:

2010

Address:

901 Shadwell Dr, San Antonio, TX 78228

VIN:

2GCEC13J981340318

Make:

CHEVROLET

Model:

SILVERADO 1500

Year:

2008