Gregory C Kellogg

US Patent:

6527432, Mar 4, 2003

Filed:

May 15, 2001

Appl. No.:

09/858581

Inventors:

Gregory J. Kellogg - Cambridge MA
Bruce L. Carvalho - Watertown MA

Assignee:

Tecan Trading AG - Baar

International Classification:

B01F 100

US Classification:

3661821, 366220, 366341, 366349, 422 72, 422 64, 422100

Abstract:

This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention particularly provides microsystem platforms for achieving efficient mixing of one or a plurality of fluids on the surface of the platform when fluid flow is motivated by centripetal force produce by rotation.

US Patent:

6548788, Apr 15, 2003

Filed:

Oct 16, 2001

Appl. No.:

09/981007

Inventors:

Gregory Kellogg - Somerville MA
Stephen G. Kieffer-Higgins - Dorchester MA
Bruce L. Carvalho - Watertown MA
Gene A. Davis - Lexington MA
John P. Willis - Shirley Center MA
Ted Minior - Bedford MA
Laura L. Chapman - Somerville MA
Mikayla Kob - Allston MA
Sarah D. Oeltjen - Somerville MA
Shari Ommert - Medford MA
Alec Mian - Cambridge MA

Assignee:

Tecan Trading AG - Baar

International Classification:

H05B 316

US Classification:

219543, 4352831, 4352864, 4352852, 4352871

Abstract:

This system provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the system provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the system are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the system is also provided.

US Patent:

6582662, Jun 24, 2003

Filed:

Jun 16, 2000

Appl. No.:

09/595239

Inventors:

Gregory J. Kellogg - Cambridge MA
David C. Duffy - Cambridge MA

Assignee:

Tecan Trading AG - Mannedorf

International Classification:

G01N 930

US Classification:

422 72, 422 50, 422 681, 422 99, 422100, 436 45, 436174, 436177, 436180

Abstract:

This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyzes and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. These assays may be performed for a variety of purposes, including but not limited to screening of drug candidate compounds, life sciences research, and clinical and molecular diagnostics. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.

US Patent:

6632399, Oct 14, 2003

Filed:

May 19, 1999

Appl. No.:

09/315114

Inventors:

Gregory Kellogg - Somerville MA
Stephen G. Kieffer-Higgins - Dorchester MA
Mona D. Jensen - Hampstead NH
Shari Ommert - Medford MA
Mikayla Kob - Allston MA
Andrea Pierce - Hollis NH
Keith Morneau - Boston MA
Hsin Chiang Lin - Cambridge MA

Assignee:

Tecan Trading AG - Baar

International Classification:

G01N 128

US Classification:

422 72, 422101, 436 45, 436177

Abstract:

This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays.

US Patent:

6656430, Dec 2, 2003

Filed:

Nov 20, 2001

Appl. No.:

09/989259

Inventors:

Alec Mian - Cambridge MA
Gregory Kellogg - Somerville MA
Stephen G. Kieffer-Higgins - Dorchester MA
Bruce L. Carvalho - Watertown MA

Assignee:

Tecan Trading AG - Baer

International Classification:

G01N 2100

US Classification:

422 63, 422 64, 422 681, 422 50, 422 72, 422101, 422102, 422 67, 436 45, 436 63, 436177, 436180, 435 71, 435 72, 435 721, 210787, 2103801, 210374, 210780, 210109, 210781

Abstract:

This invention provides methods an apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-binding based assay for specifically binding particulates including microbial cells, and a detection means for detecting the particulates specifically bound to a defined surface or chamber comprising the platform. Methods for using the analytical systems of the invention are also provided.

US Patent:

6706519, Mar 16, 2004

Filed:

Jun 22, 2000

Appl. No.:

09/602394

Inventors:

Gregory J. Kellogg - Cambridge MA
Charles Able - Cambridge MA
Todd Arnold - Glastonbury CT
Bruce L. Carvalho - Watertown MA
Hsin-Chiang Lin - Cambridge MA
Stephen Kieffer-Higgins - Boston MA
Norman F. Sheppard - Bedford MA
Mikayla Kob - Somerville MA
Shari Ommert - Stoneham MA

Assignee:

Tecan Trading AG - Baar

International Classification:

C12M 134

US Classification:

4352872, 4352865, 4352873, 4352885, 4352887, 422 64, 422 8208

Abstract:

This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The invention specifically provides devices and methods for performing miniaturized in vitro amplification assays such as the polymerase chain reaction. Methods specific for the apparatus of the invention for performing PCR are provided.

US Patent:

6719682, Apr 13, 2004

Filed:

Apr 15, 2003

Appl. No.:

10/414536

Inventors:

Gregory Kellogg - Somerville MA
Stephen G. Kieffer-Higgins - Dorchester MA
Bruce L. Carvalho - Watertown MA
Gene A. Davis - Lexington MA
John P. Willis - Shirley MA
Ted Minior - Bedford MA
Laura L. Chapman - Somerville MA
Mikayla Kob - Allston MA
Sarah D. Oeltjen - Somerville MA
Shari Ommert - Medford MA
Alec Mian - Cambridge MA

Assignee:

Tecan Trading AG - Baar

International Classification:

B04B 900

US Classification:

494 84, 464900

Abstract:

This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a micromanipulation device to manipulate the platform by rotation, thereby utilizing the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels embedded in the microplatform. The microsystem platforms of the invention are also provided having microfluidics components, resistive heating elements, temperature sensing elements, mixing structures, capillary and sacrificial valves, and methods for using these microsystems platforms for performing biological, enzymatic, immunological and chemical assays. An electronic spindle designed rotor capable of transferring electrical signals to and from the microsystem platforms of the invention is also provided.

US Patent:

6818435, Nov 16, 2004

Filed:

May 15, 2001

Appl. No.:

09/858558

Inventors:

Bruce L. Carvalho - Watertown MA
Christina Feakes - Brighton MA
Gregory J. Kellogg - Cambridge MA

Assignee:

Tecan Trading AG

International Classification:

C12M 136

US Classification:

4352865, 4352867, 4352872, 4352873, 4352887

Abstract:

This invention provides methods and apparatus for performing microanalytic analyses and procedures, particularly miniaturized cell based assays. These methods are useful for performing a variety of cell-based assays, including drug candidate screening, life sciences research, and clinical and molecular diagnostics.